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US6166130A Expired / Lapsed US ⏱️ 0.0 years remaining

Method of using crosslinked polymer compositions in tissue treatment applications

Assignee: Angiodevice International GmbH
•
Filing: 1999-04-30
•
Granted: 2000-12-26
•
Expires: 2019-04-30
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Abstract

Abstract Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (--NH 2 ) or thiol (--SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

Inventors

  • 👤 Woonza M. Rhee
  • 👤 Frank A. Delustro
  • 👤 Richard A. Berg

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-03 06:23
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61L24/00; A61L24/04; A61L24/043; A61L24/08; A61L27/00; A61L27/14; A61L27/26; A61L27/28; A61L27/34; A61L27/50; A61L27/54; A61L31/04; A61L31/041; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; C08H; C08H1/00; C08H1/06; C08L; C08L71/00; C08L71/02; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/232; A61L2300/252; A61L2300/60; A61L2300/606; Y; Y10; Y10S; Y10S623/00; Y10S623/90; Y10S623/901

Claims Analysis

Total Claims: 14
Claim 1
Independent Claim 136 words
A method of forming a three dimensional synthetic polymer matrix on a first tissue surface, comprising the steps of: (a) providing a first synthetic polymer containing m nucleophilic groups and a second synthetic polymer containing n electrophilic groups, wherein the electrophilic groups react with the nucleophilic groups to form covalent bonds therewith, wherein m and n are each greater than or equal to two, and wherein m+n is greater than or equal to five; (b) contacting the first synthetic polymer and the second synthetic polymer to initiate crosslinking; and (c) simultaneous with or subsequent to step (b), applying the first synthetic polymer and the second synthetic polymer to the first tissue surface; and (d) allowing the first synthetic polymer and the second synthetic polymer to become crosslinked to one another to form a three dimensional matrix.
Claim 2
Independent Claim 136 words
A method of forming a three dimensional synthetic polymer matrix on a first tissue surface, comprising the steps of: (a) providing a first synthetic polymer containing m nucleophilic groups and a second synthetic polymer containing n electrophilic groups, wherein the electrophilic groups react with the nucleophilic groups to form covalent bonds therewith, wherein m and n are each greater than or equal to two, and wherein m+n is greater than or equal to five; (b) contacting the first synthetic polymer and the second synthetic polymer to initiate crosslinking; and (c) simultaneous with or subsequent to step (b), applying the first synthetic polymer and the second synthetic polymer to the first tissue surface; and (d) allowing the first synthetic polymer and the second synthetic polymer to become crosslinked to one another to form a three dimensional matrix.
Claim 3
Dependent Claim 35 words
The method of claim 1, further comprising contacting the first tissue surface with a second surface after step (c) but before step (d) to effect adhesion between the first tissue surface and the second surface.
Claim 4
Dependent Claim 14 words
The method of claim 2, wherein the second surface is a native tissue surface.
Claim 5
Dependent Claim 13 words
The method of claim 2, wherein the surface is a non-native tissue surface.
Claim 6
Dependent Claim 14 words
The method of claim 4, wherein the non-native tissue surface is a synthetic implant.
Claim 7
Dependent Claim 44 words
The method of claim 5, wherein the synthetic implant is selected from the group consisting of: a donor cornea, an artificial blood vessel, a heart valve, an artificial organ, a bond prosthesis, an implantable lenticule, a vascular graft, a stent or a stent/graft combination.
Claim 8
Dependent Claim 35 words
The method of claim 1, wherein the first synthetic polymer and the second synthetic polymer are delivered from separate syringes and mixed together using syringe-to-syringe mixing prior to being applied to the first tissue surface.
Claim 9
Dependent Claim 37 words
The method of claim 1, wherein the first synthetic polymer and the second synthetic polymer are applied from separate chambers of a spray can or bottle with a spraying device and mixed at the first tissue surface.
Claim 10
Dependent Claim 21 words
The method of claim 1, wherein the first tissue surface is on or in a hard tissue or a soft tissue.
Claim 11
Dependent Claim 32 words
The method of claim 1, wherein the first tissue surface comprises, surrounds or is adjacent to a surgical site, and wherein the method further comprises the step of closing the surgical site.
Claim 12
Dependent Claim 15 words
The method of claim 1, wherein the mixture further comprises a protein or a polysaccharide.
Claim 13
Dependent Claim 11 words
The method of claim 1, wherein the mixture further comprises collagen.
Claim 14
Dependent Claim 14 words
The method of claim 1, wherein the mixture further comprises a biologically active agent.

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 2003-12-26 2004-06-26 2004-12-26 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 2007-12-26 2008-06-26 2008-12-26 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 2011-12-26 2012-06-26 2012-12-26 $7700.00 Window Closed / Lapsed

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