US4424208A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Collagen implant material and method for augmenting soft tissue
Assignee: Angiotech Biomaterials Corp
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Filing: 1982-01-11
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Granted: 1984-01-03
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Expires: 2002-01-11
Abstract
Abstract An injectable implant material for soft tissue augmentation comprising a dispersion of (a) particles of cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen in a (c) physiological aqueous carrier. Implants of this material have improved persistence relative to currently used collagen implant materials.
Inventors
- 👤 Donald G. Wallace
- 👤 Susan B. Wade
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 18:35
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K; A61K38/00; A61L2400/00; A61L2400/06; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/842
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
83 words
An injectable implant material for soft tissue augmentation comprising a dispersion of: (a) particulate cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen; dispersed in (c) an aqueous carrier wherein the total collagen in the dispersion is in the range of about 15 to about 80 mg/ml, the cross-linked collagen constitutes about 70% to 95% by weight of the total collagen in the dispersion and the fibrous collagen constitutes about 5% to about 30% by weight of the total collagen in the dispersion.
Claim 2
Dependent Claim
83 words
An injectable implant material for soft tissue augmentation comprising a dispersion of: (a) particulate cross-linked atelopeptide collagen; and (b) reconstituted fibrous atelopeptide collagen; dispersed in (c) an aqueous carrier wherein the total collagen in the dispersion is in the range of about 15 to about 80 mg/ml, the cross-linked collagen constitutes about 70% to 95% by weight of the total collagen in the dispersion and the fibrous collagen constitutes about 5% to about 30% by weight of the total collagen in the dispersion.
Claim 3
Dependent Claim
17 words
The implant material of claim 1 wherein said carrier has a substantially physiological pH and ionic strength.
Claim 4
Dependent Claim
42 words
The implant material of claim 1 wherein the particle size of the cross-linked collagen is in the range of about 50 to about 200 microns and the cross-linked collagen has a Young's modulus of about 5,000 to about 50,000 dynes/cm 2 .
Claim 5
Dependent Claim
14 words
The implant material of claim 3 wherein the cross-linked collagen is cross-linked with glutaraldehyde.
Claim 6
Dependent Claim
95 words
The implant material of claim 1 wherein the carrier has a substantially physiological pH and ionic strength; the total collagen in the dispersion is in the range of 40 to 60 mg/ml; the cross-linked collagen constitutes 75% to 85% by weight of the total collagen in the dispersion and the fibrous collagen constitutes 15% to 25% by weight of the total collagen in the dispersion; and the cross-linked collagen has a particle size in the range of about 50 to about 200 microns and a Young's modulus of about 5,000 to 50,000 dynes/cm 2 .
Claim 7
Dependent Claim
16 words
The implant material of claim 1 or 5 wherein the dispersion includes (d) a local anesthetic.
Claim 8
Dependent Claim
26 words
A method for augmenting soft tissue in a living mammal comprising injecting the material of claim 1 or 7 into the mammal at the augmentation site.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-01-02 | 1987-07-04 | 1988-01-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-01-02 | 1991-07-04 | 1992-01-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-01-02 | 1995-07-04 | 1996-01-03 | $7700.00 | Window Closed / Lapsed |