US4515637A
Expired / Lapsed
US
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Collagen-thrombin compositions
Assignee: Seton Co
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Filing: 1983-11-16
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Granted: 1985-05-07
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Expires: 2003-11-16
Abstract
Abstract A method of forming a collagen-thrombin hemostatic composition is comprised of forming a homogeneous aqueous admixture of collagen and thrombin at a basic pH and lyophilizing the collagen-thrombin admixture to form a stable collagen sponge having thrombin therein. The collagen utilized in the process is absorbable when placed in vivo. Additionally, a lyophilized collagen product is comprised of collagen which is absorbable when placed in vivo and thrombin distributed within the collagen. The collagen product is storage stable.
Inventors
- 👤 Gheorghe Cioca
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:28
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/64; A61L15/22; A61L15/32; A61L15/325; A61L15/425; C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A61L2400/00; A61L2400/04
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
71 words
A method of forming a collagen-thrombin hemostatic composition consisting essentially of: forming a homogeneous aqueous admixture of collagen and thrombin at a basic pH, wherein the ratio of collagen to thrombin is about 0.1 gram of collagen to about 300 units or greater of thrombin; and lyophilizing said collagen-thrombin admixture to form a stable collagen sponge having thrombin distributed uniformly throughout and wherein said collagen is absorbable when placed in vivo.
Claim 2
Independent Claim
71 words
A method of forming a collagen-thrombin hemostatic composition consisting essentially of: forming a homogeneous aqueous admixture of collagen and thrombin at a basic pH, wherein the ratio of collagen to thrombin is about 0.1 gram of collagen to about 300 units or greater of thrombin; and lyophilizing said collagen-thrombin admixture to form a stable collagen sponge having thrombin distributed uniformly throughout and wherein said collagen is absorbable when placed in vivo.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein said collagen-thrombin aqueous admixture is at a pH of about 7.1 to about 8.0.
Claim 4
Dependent Claim
19 words
The method of claim 1 wherein the aqueous admixture is about 0.1 to about 0.6 percent by weight collagen.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein said collagen is native collagen.
Claim 6
Dependent Claim
12 words
The method of claim 1 wherein said collagen is natural insoluble collagen.
Claim 7
Dependent Claim
29 words
A lyophilized collagen product, active ingredients consisting essentially of collagen which is absorbable when placed in vivo and thrombin distributed uniformly throughout said collagen, said product being storage stable.
Claim 8
Dependent Claim
29 words
A lyophilized collagen product, active ingredients consisting essentially of collagen which is absorbable when placed in vivo and thrombin distributed uniformly throughout said collagen, said product being storage stable.
Claim 9
Dependent Claim
16 words
The collagen product of claim 6 wherein said collagen is in the form of a sponge.
Claim 10
Dependent Claim
27 words
The collagen product of claim 6 wherein the ratio of collagen to thombin is about 0.1 gram of collagen to about 300 units or greater of thrombin.
Claim 11
Dependent Claim
13 words
The collagen product of claim 6 wherein said collagen is natural insoluble collagen.
Claim 12
Dependent Claim
12 words
The collagen product of claim 6 wherein said collagen is native collagen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-05-06 | 1988-11-05 | 1989-05-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-05-06 | 1992-11-05 | 1993-05-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-05-06 | 1996-11-05 | 1997-05-07 | $7700.00 | Window Closed / Lapsed |