Patent US3448275A successfully refreshed from Google Patents.
US4414976A
Expired / Lapsed
US
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Tissue adhesive
Assignee: Oesterreichisches Institut fuer Haemoderivate
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Filing: 1982-09-13
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Granted: 1983-11-15
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Expires: 2002-09-13
Abstract
Abstract A tissue adhesive on the basis of human or animal protein contains factor XIII and at least 33% by weight of fibrinogen, has a ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen, of at least 80, contains fibrinogen and albumin in the total protein at a ratio of 33 to 90:5 to 40, contains plasminogen-activator-inhibitor or plasmin inhibitor in an amount of 250 to 25,000 KIU per g of fibrinogen and has been lyophilized.
Inventors
- 👤 Otto Schwarz
- 👤 Yendra Linnau
- 👤 Franz Loblich
- 👤 Thomas Seelich
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:06
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K38/00; A61K38/005; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
128 words
A method of seamlessly connecting tissue or organ parts, for sealing wounds, stopping bleeding and stimulating wound healing in mammals which comprises reconstituting lyophilized tissue adhesive of mammalian protein origin which comprises fibrinogen, albumin, factor XIII, cold-insoluble globulin and plasminogen-activator inhibitor or plasmin inhibitor wherein the fibrinogen is present in at least 33% by weight, in the lyophilized state, the ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen is at least 80, and fibrinogen and albumin are present in a ratio of 33 to 90:5 to 40 and applying said reconstituted tissue adhesive containing at least 70 mg of fibrinogen per ml to the organ tissue or wound of a mammal in an amount sufficient to function as an adhesive.
Claim 2
Independent Claim
128 words
A method of seamlessly connecting tissue or organ parts, for sealing wounds, stopping bleeding and stimulating wound healing in mammals which comprises reconstituting lyophilized tissue adhesive of mammalian protein origin which comprises fibrinogen, albumin, factor XIII, cold-insoluble globulin and plasminogen-activator inhibitor or plasmin inhibitor wherein the fibrinogen is present in at least 33% by weight, in the lyophilized state, the ratio of factor XIII to fibrinogen, expressed in units of factor XIII per gram of fibrinogen is at least 80, and fibrinogen and albumin are present in a ratio of 33 to 90:5 to 40 and applying said reconstituted tissue adhesive containing at least 70 mg of fibrinogen per ml to the organ tissue or wound of a mammal in an amount sufficient to function as an adhesive.
Claim 3
Dependent Claim
25 words
A method as set forth in claim 1, wherein the tissue adhesive and a mixture of thrombin and calcium chloride are applied onto the tissue.
Claim 4
Dependent Claim
33 words
A method as set forth in claim 1, wherein, prior to applying the tissue adhesive onto the tissue to be connected, a mixture of thrombin and calcium chloride is added to the adhesive.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-14 | 1987-05-16 | 1987-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-14 | 1991-05-16 | 1991-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-14 | 1995-05-16 | 1995-11-15 | $7700.00 | Window Closed / Lapsed |