US3960830A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyalkylene glycols used for the preparation of peptides
Assignee: Hoechst AG
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Filing: 1974-12-04
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Granted: 1976-06-01
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Expires: 1994-12-04
Abstract
Abstract A process for the synthesis of peptides in a liquid phase wherein the peptide product, and intermediates in the peptide synthesis, are bound to a polyalkylene glycol polymer and wherein the polymer-bound peptide is separated from the liquid phase, e.g. for purposes of isolation or purification, by crystallizing the polymer-bound peptide.
Inventors
- 👤 Ernst Bayer
- 👤 Manfred Mutter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 04:05
CPC Classifications
C; C07; C07K; C07K1/00; C07K1/06; C07K1/061; C07K1/062; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; C07K1/04; C07K1/042
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
149 words
In a process for synthesizing a peptide in a liquid phase by at least once forming a peptide bond between a carboxy group of an amino acid or peptide and an amino group of an amino acid or peptide, which latter amino acid or peptide has a carboxy group bound by an ester bond to an hydroxy group of a polymer which is a. a polyalkylene glycol, the alkylene group of which has 2 or 3 carbon atoms, or b. such a polyalkylene glycol which has been mono-esterified or mono-etherified, whereby a new polymer-bonded peptide is formed, and then cleaving said ester bond at the conclusion of the synthesis, the improvement wherein said polymer has a molecular weight between 2000 and 40000 and wherein, prior to cleavage of said ester bond, said polymer-bound peptide is crystallized at least once during the synthesis to separate it from said liquid phase.
Claim 2
Dependent Claim
149 words
In a process for synthesizing a peptide in a liquid phase by at least once forming a peptide bond between a carboxy group of an amino acid or peptide and an amino group of an amino acid or peptide, which latter amino acid or peptide has a carboxy group bound by an ester bond to an hydroxy group of a polymer which is a. a polyalkylene glycol, the alkylene group of which has 2 or 3 carbon atoms, or b. such a polyalkylene glycol which has been mono-esterified or mono-etherified, whereby a new polymer-bonded peptide is formed, and then cleaving said ester bond at the conclusion of the synthesis, the improvement wherein said polymer has a molecular weight between 2000 and 40000 and wherein, prior to cleavage of said ester bond, said polymer-bound peptide is crystallized at least once during the synthesis to separate it from said liquid phase.
Claim 3
Dependent Claim
45 words
A process as in claim 1 wherein a plurality of peptide bonds are formed in a plurality of sequential steps during the peptide synthesis and wherein the new polymer-bound peptide formed in each of the sequential steps is separated from said liquid phase by crystallization.
References Cited (Backward Citations)
US3645852A
Cited
US3502545A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-01 | 1979-12-01 | 1980-06-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-01 | 1983-12-01 | 1984-06-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-01 | 1987-12-01 | 1988-06-01 | $7700.00 | Window Closed / Lapsed |