US5292802A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Collagen-polymer tubes for use in vascular surgery
Assignee: Surgical Specialties US Corp
•
Filing: 1992-12-02
•
Granted: 1994-03-08
•
Expires: 2012-12-02
Abstract
Abstract Medical articles in the form of tubes are formed by covalently binding collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugate formulations which are used to make the tubes. The collagen may be recombinantly produced human collagen or collagen extracted from any source, such as a bovine or human placental source, and purified and can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The tube can be designed to incorporate other components such as liquid, pharmaceutically acceptable, carriers, and/or biologically active proteins such as growth factors or cytokines. The tubes contain large amounts of water when extruded and then may be dehydrated to form relatively solid but flexible tubes which can be easily stored. The tubes can be surgically implanted and attached to, or implanted within, a channel in a mammal for the purpose of repairing the channel. The tubes can be used to repair a wide range of different types of channels including but not limited to veins and arteries.
Inventors
- 👤 Woonza Rhee
- 👤 Kimberly McCullough
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:37
CPC Classifications
C; C08; C08L; C08L89/00; C08L89/04; C08L89/06; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K47/61; A61K47/62; A61K47/64; A61K47/6435; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/225; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; A61L27/00; A61L27/14; A61L27/18; A61L27/20; A61L27/22; A61L27/24; A61L27/26; A61L27/28; A61L27/34; A61L27/40; A61L27/44; A61L27/50; A61L27/54; A61L29/00; A61L29/04; A61L29/043; A61L29/044; A61L29/045; A61L29/06; A61L29/14; A61L29/16; A61L31/00; A61L31/04; A61L31/041; A61L31/042; A61L31/043; A61L31/044; A61L31/08; A61L31/10; A61L31/12; A61L31/125; A61P; A61P17/00; A61P43/00; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/495; C07K14/78; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0069; C08B37/0072; C08H; C08H1/00; C08H1/06; C09; C09J; C09J189/00; C09J189/04; C09J189/06; G; G02; G02B; G02B1/00; G02B1/04; G02B1/041; G02B1/043; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K38/00; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/40; A61L2300/412; A61L2300/414; A61L2300/426; A61L2300/60; A61L2300/62; A61L2300/80; A61L2300/802; A61L2430/00; A61L2430/16; C08L2666/00; C08L2666/02; Y; Y10; Y10S; Y10S525/00; Y10S525/937
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
80 words
A hollow, flexible tube having a circular cross-section, an outer diameter in the range of about 0.25 mm to about 5.0 cm , an inner diameter in the range of 0.05 mm to 4.95 cm, and a length of greater than 10 mm, the tube comprising collagen chemically conjugated to a synthetic non-immunogenic hydrophilic polymer by a covalent bond wherein the covalent bond is selected from the group consisting of an ester linkage, a urethane linkage, and an ether linkage.
Claim 2
Dependent Claim
80 words
A hollow, flexible tube having a circular cross-section, an outer diameter in the range of about 0.25 mm to about 5.0 cm , an inner diameter in the range of 0.05 mm to 4.95 cm, and a length of greater than 10 mm, the tube comprising collagen chemically conjugated to a synthetic non-immunogenic hydrophilic polymer by a covalent bond wherein the covalent bond is selected from the group consisting of an ester linkage, a urethane linkage, and an ether linkage.
Claim 3
Dependent Claim
10 words
The tube of claim 1, wherein the tube is dehydrated.
Claim 4
Dependent Claim
16 words
The tube of claim 1, wherein the synthetic hydrophilic polymer is a difunctionally activated polyethylene glycol.
Claim 5
Dependent Claim
13 words
The tube of claim 1, wherein the polymer is difunctional polyethylene glycol succinimidyl.
Claim 6
Dependent Claim
17 words
The tube of claim 1, further comprising: a therapeutically effective amount of a cytokine or growth factor.
Claim 7
Dependent Claim
70 words
The tube of claim 5, wherein said cytokine or growth factor is selected from the group consisting of epidermal growth factor, transforming growth factor-α, transforming growth factor-β, transforming growth factor-β2, platelet-derived growth factor-AA, platelet-derived growth factor-AB, platelet-derived growth factor-BB, acidic fibroblast growth factor, basic fibroblast growth factor, connective tissue activating peptide, β-thromboglobulin, insulin-like growth factors, tumor necrosis factor, interleukins, colony stimulating factors, erythropoietin, nerve growth factor, interferons, and osteogenic factors.
Claim 8
Dependent Claim
27 words
The tube of claim 6, wherein said growth factor is selected from the group consisting of transforming growth factor-β, transforming growth factor-β1, transforming growth factor-β2, and erythropoietin.
Claim 9
Dependent Claim
16 words
The tube of claim 1, wherein the synthetic hydrophilic polymer is a succinimidyl monomethylpolyethylene glycol glutarate.
Claim 10
Dependent Claim
34 words
The tube of claim 1, wherein the conjugate has the following general structural formula: collagen--HN--OC--(CH.sub.2).sub.n --O--PEG--O--(CH.sub.2).sub.n --CO--NH--collagen wherein n is an integer selected from the group consisting of 0, 1, 2, 3, or 4.
Claim 11
Dependent Claim
41 words
The tube of claim 1, wherein the collagen is selected from the group consisting of type I, type II and type III collagen and the polymer is polyethylene glycol having a weight average molecular weight of about 100 to about 20,000.
Claim 12
Dependent Claim
20 words
The tube of claim 10, wherein said synthetic hydrophilic polymer is bound to an available lysine residue on said collagen.
Claim 13
Dependent Claim
12 words
The tube of claim 10, wherein said collagen is atelopeptide fibrillar collagen.
Claim 14
Dependent Claim
13 words
The tube of claim 1, wherein the covalent bond is an ether linkage.
Claim 15
Independent Claim
82 words
A method of repairing a channel in a mammal comprising attaching to a channel in need of repair a tube having an outer diameter in the range of about 0.25 mm to about 5.0 cm, and a length of more than 5 mm, the tube being comprised of collagen chemically conjugated to a synthetic non-immunogenic hydrophilic polymer by a covalent bond wherein the covalent bond is selected from the group consisting of an ester linkage, a urethane linkage, and an ether linkage.
Claim 16
Independent Claim
82 words
A method of repairing a channel in a mammal comprising attaching to a channel in need of repair a tube having an outer diameter in the range of about 0.25 mm to about 5.0 cm, and a length of more than 5 mm, the tube being comprised of collagen chemically conjugated to a synthetic non-immunogenic hydrophilic polymer by a covalent bond wherein the covalent bond is selected from the group consisting of an ester linkage, a urethane linkage, and an ether linkage.
Claim 17
Dependent Claim
28 words
The method of claim 14, further comprising: hydrating the tube by placing the tube in contact with an aqueous solution prior to attaching the tube to the channel.
Claim 18
Dependent Claim
32 words
The method of claim 15, wherein the synthetic, hydrophilic, non-immunogenic polymer has the following structural formula: ##STR8## wherein n is selected from the group consisting of 0, 1, 2, 3 and 4.
Claim 19
Dependent Claim
17 words
The method of claim 15, wherein the synthetic, hydrophilic, non-immunogenic polymer has the following structural formula: ##STR9##
Claim 20
Dependent Claim
17 words
The method of claim 15, wherein the synthetic, hydrophilic, non-immunogenic polymer has the following structural formula: ##STR10##
Claim 21
Dependent Claim
32 words
The method of claim 15, wherein the synthetic, hydrophilic, non-immunogenic polymer has the following structural formula: ##STR11## wherein n is selected from the group consisting of 0, 1, 2, 3 and 4.
Claim 22
Dependent Claim
33 words
The method of claim 15, wherein the mammal is a human and the channel is selected from the group consisting of a vein, artery, intestine, fallopian tube, vas deferens, urethra, esophagus and trachea.
Claim 23
Dependent Claim
13 words
The method of claim 14, wherein the covalent bond is an ether linkage.
Claim 24
Independent Claim
85 words
A method of repairing a channel in a mammal comprising: placing a tube in a channel in need of repair, wherein the tube has an outer diameter in the range of about 0.25 mm to about 5.0 cm, and a length of more than 2 cm, the tube being comprised of collagen chemically conjugated to a synthetic, non-immunogenic, hydrophilic polymer by a covalent bond wherein the covalent bond is selected from the group consisting of an ester linkage, a urethane linkage, and an ether linkage.
Claim 25
Independent Claim
85 words
A method of repairing a channel in a mammal comprising: placing a tube in a channel in need of repair, wherein the tube has an outer diameter in the range of about 0.25 mm to about 5.0 cm, and a length of more than 2 cm, the tube being comprised of collagen chemically conjugated to a synthetic, non-immunogenic, hydrophilic polymer by a covalent bond wherein the covalent bond is selected from the group consisting of an ester linkage, a urethane linkage, and an ether linkage.
Claim 26
Dependent Claim
13 words
The method of claim 22, wherein the covalent bond is an ether linkage.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-03-07 | 1997-09-06 | 1998-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-03-07 | 2001-09-06 | 2002-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-03-07 | 2005-09-06 | 2006-03-08 | $7700.00 | Window Closed / Lapsed |