US4642117A
Expired / Lapsed
US
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Mechanically sheared collagen implant material and method
Assignee: Allergan Inc
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Filing: 1985-03-22
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Granted: 1987-02-10
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Expires: 2005-03-22
Abstract
Abstract An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers. The material is prepared by passing reconstituted collagen fibers repeatedly through a rigid mesh screen, until a substantial reduction in fiber size and size-heterogeneity is achieved. The mechanically sheared fibers may be further crosslinked to improve implant characteristics.
Inventors
- 👤 Hoc M. Nguyen
- 👤 George H. Chu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:21
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; A61K; A61K38/00; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
80 words
An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers and characterized, with respect to unsheared, but otherwise identical, collagen material measured under the same conditions, by: about a 30%-70% decrease in the force required to inject the material, at a concentration of between about 35-65 mg/ml, through a 27-30 gauge needle, and b. a substantial decrease in the number and magnitude of transient increases in force required for injecting the material, at such concentration, through such needle.
Claim 2
Dependent Claim
80 words
An injectable collagen material composed of reconstituted, mechanically sheared atelopeptide collagen fibers and characterized, with respect to unsheared, but otherwise identical, collagen material measured under the same conditions, by: about a 30%-70% decrease in the force required to inject the material, at a concentration of between about 35-65 mg/ml, through a 27-30 gauge needle, and b. a substantial decrease in the number and magnitude of transient increases in force required for injecting the material, at such concentration, through such needle.
Claim 3
Dependent Claim
18 words
The material of claim 1, wherein the nominal size of the fibers is less than about 200 microns.
Claim 4
Dependent Claim
20 words
The material of claim 2 wherein the fibers are in the size range of between about 50 and 150 microns.
Claim 5
Dependent Claim
51 words
The material of claim 1, which has a viscosity, measured at shear rates varying from 10 -6 to 10 -2 sec -1 , at 20° C. and at a protein concentration of about 65 mg/ml, about 20-30% less than that of unsheared but otherwise identical material measured under the same conditions.
Claim 6
Dependent Claim
19 words
The material of claim 1, resulting from crosslinking the mechanically sheared fibers under conditions which produce predominantly intrafibrillar crosslinks.
Claim 7
Dependent Claim
50 words
The material of claim 5 which, at a concentration of about 35 mg/ml, has a viscosity, measured at shear rates ranging from 10 -6 to 10 -2 sec -1 , at 20° C., about 40-60% lower than that of unsheared but otherwise identical crosslinked material measured under the same conditions.
Claim 8
Dependent Claim
35 words
The material of claim 1, wherein the fibers are mechanically sheared by repeated passage through a wire mesh screen under conditions which produce a more than two-fold reduction in the size of the largest fibers.
Claim 9
Dependent Claim
81 words
An injectable collagen material composed of reconstituted, crosslinked, mechanically sheared atelopeptide collagen fibers and characterized, with respect to unsheared collagen, but otherwise identical, material measured under the same conditions, by: about a 30%-70% decrease in the force required to inject the material, at a concentration of between about 35-65 mg/ml, through a 27-30 gauge needle, and b. a substantial decrease in the number and magnitude of transient increases in force required for injecting the material, at such concentration, through such needle.
Claim 10
Dependent Claim
81 words
An injectable collagen material composed of reconstituted, crosslinked, mechanically sheared atelopeptide collagen fibers and characterized, with respect to unsheared collagen, but otherwise identical, material measured under the same conditions, by: about a 30%-70% decrease in the force required to inject the material, at a concentration of between about 35-65 mg/ml, through a 27-30 gauge needle, and b. a substantial decrease in the number and magnitude of transient increases in force required for injecting the material, at such concentration, through such needle.
Claim 11
Dependent Claim
21 words
The material of claim 8, contained in a substantially isotonic medium, pH 6-8, at a concentration of between about 15-70 mg/ml.
Claim 12
Dependent Claim
12 words
The material of claim 8, wherein the fibers contain substantially intrafibrillar crosslinks.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-09 | 1990-08-11 | 1991-02-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-09 | 1994-08-11 | 1995-02-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-09 | 1998-08-11 | 1999-02-10 | $7700.00 | Window Closed / Lapsed |