US4301144A
Expired / Lapsed
US
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Blood substitute containing modified hemoglobin
Assignee: Ajinomoto Co Inc
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Filing: 1980-07-10
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Granted: 1981-11-17
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Expires: 2000-07-10
Abstract
Abstract A novel modified hemoglobin was prepared. The hemoglobin is coupled with a polyalkylene glycol or its derivative, and the products are useful as a blood substitute. The oxygen-carrying capacity of this hemoglobin is nearly equal to that of a native hemoglobin, and the residence time in the circulation is satisfactorily long.
Inventors
- 👤 Yuji Iwashita
- 👤 Katsumi Ajisaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 03:34
CPC Classifications
C; C08; C08G; C08G65/00; C08G65/02; C08G65/32; A; A61; A61P; A61P7/00; A61P7/08; C07; C07K; C07K14/00; C07K14/795; C07K14/805; C08L; C08L71/00; C08L71/02; A61K; A61K38/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
96 words
An oxygen carrying material which comprises hemoglobin attached by a chemical reaction to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, a copolymer of ethylene glycol with propylene glycol, an ether of one of the above polyethylene glycols with an alcohol having a carbon number of 1 to 16, an ester of one of the above polyalkylene glycols with a carboxylic acid having a carbon number of 2 to 18, and a dehydrated product of one of the above polyalkylene glycols with an amine having a carbon number of 1 to 18.
Claim 2
Dependent Claim
96 words
An oxygen carrying material which comprises hemoglobin attached by a chemical reaction to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, a copolymer of ethylene glycol with propylene glycol, an ether of one of the above polyethylene glycols with an alcohol having a carbon number of 1 to 16, an ester of one of the above polyalkylene glycols with a carboxylic acid having a carbon number of 2 to 18, and a dehydrated product of one of the above polyalkylene glycols with an amine having a carbon number of 1 to 18.
Claim 3
Dependent Claim
14 words
The material of claim 1 wherein said polymer has a molecular weight of 300-20,000.
Claim 4
Dependent Claim
11 words
The material of claim 2 wherein said molecular weight is 750-5,000.
Claim 5
Dependent Claim
17 words
The material of claim 1 wherein said hemoglobin and said polymer are attached to each other directly.
Claim 6
Dependent Claim
22 words
The material of claim 1 wherein said hemoglobin and said polymer are attached to each other by means of a cross-linking agent.
Claim 7
Dependent Claim
33 words
In a method of carrying oxygen to an animal tissue by means of an oxygen carrier, the improvement which comprises using as an oxygen carrier the attached hemoglobin polymer material of claim 1.
Claim 8
Dependent Claim
29 words
The material of claim 1 wherein said attachment of said hemoglobin to said polymer occurs by reacting said hemoglobin with said polymer which has been pretreated with cyanogen bromide.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-16 | 1985-05-18 | 1985-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-16 | 1989-05-18 | 1989-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-16 | 1993-05-18 | 1993-11-17 | $7700.00 | Window Closed / Lapsed |