US4412989A
Expired / Lapsed
US
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Oxygen carrier
Assignee: Ajinomoto Co Inc
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Filing: 1982-06-03
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Granted: 1983-11-01
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Expires: 2002-06-03
Abstract
Abstract An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.
Inventors
- 👤 Yuji Iwashita
- 👤 Katsumi Ajisaka
- 👤 Keiji Iwasaki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:37
CPC Classifications
C; C08; C08G; C08G65/00; C08G65/02; C08G65/32; C08G65/329; A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61P; A61P7/00; A61P7/08; C07; C07K; C07K14/00; C07K14/795; C07K14/805; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
37 words
An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.
Claim 2
Dependent Claim
37 words
An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.
Claim 3
Dependent Claim
62 words
The material of claim 1 wherein a hydroxyl group of said polymer is substituted with an alcohol having a carbon number of 1 to 16, a carboxylic acid having a carbon number of 2 to 18, or an amide having a carbon number of 1 to 18, and hemoglobin or a hemoglobin derivative is coupled to said polymer through an amide bond.
Claim 4
Dependent Claim
23 words
The material of claim 1 wherein hemoglobin is coupled to said polymer through an amide bond by the help of a carboxylic acid.
Claim 5
Dependent Claim
22 words
The material of claim 3 wherein said carboxylic acid is selected from the group consisting of monohalogenated carboxylic acids and dicarboxylic acids.
Claim 6
Dependent Claim
34 words
The material of claim 1 wherein said hemoglobin is modified with pyridoxal, a phosphate or sulfate containing derivative of pyridoxal, a sugar phosphate, 2,3-phosphoglyceric acid, or a sugar derivative containing a carboxylic acid group.
Claim 7
Dependent Claim
15 words
The material of claim 5 wherein said derivative of pyridoxal is pyridoxal-5'-phosphate, pyridoxal-5'-sulphate, or 2-Nor-2-formylpyridoxal-5'-phosphate.
Claim 8
Dependent Claim
11 words
The material of claim 5 wherein said sugar phosphate is glucose-6-phosphate.
Claim 9
Dependent Claim
16 words
The material of claim 1 wherein said polymer has a molecular weight of 300 to 20,000.
Claim 10
Dependent Claim
13 words
The material of claim 8 wherein said molecular weight is 750 to 10,000.
Claim 11
Dependent Claim
31 words
In a method of carrying oxygen to animal tissues by use of an oxygen carrier, the improvement which comprises using the oxygen carrying material of claim 1 as an oxygen carrier.
Claim 12
Independent Claim
80 words
A method of preparing a hemoglobin-polymer complex for an oxygen carrier as a blood substitute by chemical reaction, in which the polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide, comprising: (1) introducing at least one carboxylic acid group to said polymer to give a carboxylic acid-containing polymer, and (2) coupling the carboxylic acid-containing polymer through an amide bond with an amino group of hemoglobin or a hemoglobin derivative.
Claim 13
Independent Claim
80 words
A method of preparing a hemoglobin-polymer complex for an oxygen carrier as a blood substitute by chemical reaction, in which the polymer is selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide, comprising: (1) introducing at least one carboxylic acid group to said polymer to give a carboxylic acid-containing polymer, and (2) coupling the carboxylic acid-containing polymer through an amide bond with an amino group of hemoglobin or a hemoglobin derivative.
Claim 14
Dependent Claim
32 words
The method of claim 11 wherein a carboxylic acid selected from the group consisting of monohalogenated carboxylic acids and dicarboxylic acids is reacted with said polymer to introduce said carboxylic acid group.
References Cited (Backward Citations)
US4301144A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-31 | 1987-05-02 | 1987-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-31 | 1991-05-02 | 1991-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-31 | 1995-05-02 | 1995-11-01 | $7700.00 | Window Closed / Lapsed |