EP0098110A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Long-acting composition
Assignee: NIHON CHEMICAL RESEARCH also known as JAPAN CHEMICAL RESEARCH Co Ltd KK
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Filing: 1983-06-23
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Granted: —
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Expires: 2003-06-23
Abstract
Abstract A composition wherein a physiologically active polypeptide or a glycoprotein for instance, urokinase, kallikrein or leukocyte interferon, is coupled to a polyoxyethylene-polyoxypropylene copolymer. The composition is effective in vivo for a prolonged period of time.
Inventors
- 👤 Hajime Hiratani
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:05
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/56; A61K47/59; A61K47/60; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/21; A61K38/212; A61K38/43; A61K38/46; A61K38/48; A61K38/482; A61K38/4853; A61K38/49; C; C07; C07K; C07K17/00; C07K17/02; C07K17/06; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/089; C12Y; C12Y304/00; C12Y304/21; C12Y304/21031; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
55 words
A long-acting composition comprising a physiologically active polypeptide or glycoprotein characterised in that the polypeptide or glycoprotein is coupled to a polyoxyethylene-polyoxypropylene copolymer having a molecular weight of 10,000 or less by means of a coupling agent capable of linking a terminal hydroxyl group of said copolymer with an amino group of said active substance.
Claim 2
Dependent Claim
55 words
A long-acting composition comprising a physiologically active polypeptide or glycoprotein characterised in that the polypeptide or glycoprotein is coupled to a polyoxyethylene-polyoxypropylene copolymer having a molecular weight of 10,000 or less by means of a coupling agent capable of linking a terminal hydroxyl group of said copolymer with an amino group of said active substance.
Claim 3
Dependent Claim
18 words
A composition as claimed in Claim 1, wherein the physiologically active polypeptide or glycoprotein is of human origin.
Claim 4
Dependent Claim
57 words
A composition as claimed in Claim 2, wherein said polypeptide or glycoprotein is human menopausal gonadotropin, human growth hormone, epidermal growth factor, nerve growth factor, colony formation simulating factor, urokinase, plasminogen (PLG), kallikrein, interferon α, interferon p, interferon Y, interleukin 1, interleukin 2, urinary tripsin inhibitor, urinary thiol protease inhibitor, placental arylsulfatase, urinary lysozyme or urinary asparaginase.
Claim 5
Dependent Claim
20 words
A composition as claimed in Claim 2, wherein the physiologically active polypeptide or glycoprotein is urokinase, kallikrein or leukocyte interferon.
Claim 6
Dependent Claim
23 words
A composition as claimed in any one of the preceding Claims, wherein the copolymer has a polyoxyethylene- polyoxypropylene ratio from 4:16 to 256:54.
Claim 7
Dependent Claim
41 words
A composition as claimed in any one of the preceding Claims, wherein the copolymer has a molecular weight of 1,000 to 10,000 having at both ends thereof hydroxyl groups one of which may be substituted by an alkyl or acyl group.
Claim 8
Dependent Claim
30 words
A composition as claimed in Claim 6, wherein the copolymer is a methoxy-polyoxyethylene-polyoxypropylene copolymer having E.O.:P.O.:E.O. ratio of 46 : 16 : 46 and has average molecular weight of 5,000.
Claim 9
Dependent Claim
29 words
A composition as claimed in Claim 6 wherein the copolymer is an ethoxy-polyoxyethylene-polyoxypropylene glycol having average molecular weight of 3,400 and E.O.:P.O.:E.O. ratio of 15 : 30 : 19.
Claim 10
Dependent Claim
41 words
A composition as claimed in any one of the preceding Claims wherein the coupling agent contains at least one functional group capable of reacting with a hydroxyl group and at least one functional group capable of reacting with an amino group.
Claim 11
Dependent Claim
18 words
A composition as claimed in Claim 9 wherein the coupling agent is 2,4,6-trichloro-s-triazine, dibromosuccinic anhydride or maleic anhydride.
References Cited (Backward Citations)
No citation records indexed.
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