US4789663A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of bone repair using collagen
Assignee: Angiotech Biomaterials Corp
•
Filing: 1985-07-05
•
Granted: 1988-12-06
•
Expires: 2005-07-05
Abstract
Abstract A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats.
Inventors
- 👤 Donald G. Wallace
- 👤 Thomas L. Smestad
- 👤 John M. McPherson
- 👤 Karl A. Piez
- 👤 Saeid Seyedin
- 👤 Rosa Armstrong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:45
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A61F; A61F2/00; A61F2/02; A61F2/28; A61F2002/2835; A61F2310/00; A61F2310/00005; A61F2310/00365
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
89 words
A method of effecting conductive repair of a bone defect in a mammal, which method comprises: (a) exposing fresh bone surface comprising living osteoprogenitor cells to the defect; (b) placing into the defect and into contact with the fresh bone surface a preparation of collagen selected from the group consisting of: (1) a composition consisting essentially of Type I collagen derived from demineralized, protease-treated, delipidized bone; (2) a lyophilized gel of purified atelopeptide reconstituted fibrillar skin collagen; and (3) mixtures of (1) and purified atelopeptide reconstituted fibrillar skin collagen.
Claim 2
Independent Claim
89 words
A method of effecting conductive repair of a bone defect in a mammal, which method comprises: (a) exposing fresh bone surface comprising living osteoprogenitor cells to the defect; (b) placing into the defect and into contact with the fresh bone surface a preparation of collagen selected from the group consisting of: (1) a composition consisting essentially of Type I collagen derived from demineralized, protease-treated, delipidized bone; (2) a lyophilized gel of purified atelopeptide reconstituted fibrillar skin collagen; and (3) mixtures of (1) and purified atelopeptide reconstituted fibrillar skin collagen.
Claim 3
Dependent Claim
17 words
The method of claim 1 wherein the preparation of collagen in (2) is prepared from calf skin.
Claim 4
Dependent Claim
21 words
The method of claim 1 wherein the preparation of collagen in (2) is in the form of a mat or sheet.
Claim 5
Dependent Claim
17 words
The method of claim 1 wherein the preparation of collagen in (2) is substantially free of cross-linking.
Claim 6
Dependent Claim
16 words
A purified collagen preparation consisting essentially of Type I collagen derived from demineralized, protease-treated, delipidized bone.
Claim 7
Dependent Claim
16 words
A purified collagen preparation consisting essentially of Type I collagen derived from demineralized, protease-treated, delipidized bone.
Claim 8
Dependent Claim
81 words
A process for preparing bone collagen powder, which bone collagen powder is a composition consisting essentially of Type I collagen derived from demineralized, protease-treated, delipidized bone, which process comprises: (a) treating demineralized bone powder with at least one protease selected from trypsin and pepsin to obtain soluble products and a collagen-containing residue; (b) extracting the soluble products, (c) recovering the residue, and (d) extracting the residue with a solvent to obtain a delipidized form of the residue as bone collagen powder.
Claim 9
Dependent Claim
81 words
A process for preparing bone collagen powder, which bone collagen powder is a composition consisting essentially of Type I collagen derived from demineralized, protease-treated, delipidized bone, which process comprises: (a) treating demineralized bone powder with at least one protease selected from trypsin and pepsin to obtain soluble products and a collagen-containing residue; (b) extracting the soluble products, (c) recovering the residue, and (d) extracting the residue with a solvent to obtain a delipidized form of the residue as bone collagen powder.
Claim 10
Dependent Claim
10 words
Bone collagen powder prepared by the process of claim 6.
Claim 11
Dependent Claim
18 words
The process of claim 6 which further includes enzymatically treating the demineralized bone to remove non-proteinaceous bone components.
Claim 12
Dependent Claim
15 words
The method of claim 6 wherein the solvent is selected from acetone, chloroform, and ether.
Claim 13
Dependent Claim
17 words
The method of claim 6 which includes the further step of sterilization of the bone collagen powder.
References Cited (Backward Citations)
US2621145A
Cited
US3318774A
Cited
US3458397A
Cited
US3443261A
Cited
US3820167A
Cited
US3918100A
Cited
US3919723A
Cited
US3949073A
Cited
US4140537A
Cited
US4066083A
Cited
US4294241A
Cited
US4186486A
Cited
EP0012959A1
Cited
EP0012443A1
Cited
US4294753A
Cited
US4314380A
Cited
EP0071242A2
Cited
US4394370A
Cited
US4440750A
Cited
US4434094A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-12-06 | 1992-06-06 | 1992-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-12-06 | 1996-06-06 | 1996-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-12-06 | 2000-06-06 | 2000-12-06 | $7700.00 | Window Closed / Lapsed |