Patent EP0380666A1 successfully refreshed from Google Patents.
EP0154447B1
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EP
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Compositions and method for improving wound healing
Assignee: University of California, San Diego
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Filing: 1985-02-20
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Granted: 1990-12-05
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Expires: 2005-02-20
Abstract
Abstract The healing of wounds is promoted by contacting the wound surfaces with a suspension of collagen and a glycosaminoglycan that is chemotactic for fibroblasts and/or endothelial cells. Typical glycosaminoglycans that exhibit the desired chemotaxis are heparin, heparan sulfate, and alginate. Two or more glycosaminoglycans can be present in the suspensions. Collagen is present in the suspension in the order of 7-10 mg/ml; while the glycosaminoglycan is present in much lower concentrations, e.g, 250-350 µg/ml. Application of the collagen/glycosaminoglycan suspension to open wounds greatly increases the rate of healing.
Inventors
- 👤 Dov Michaeli
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 12:53
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61P; A61P17/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
41 words
A composition for use in promoting wound healing which is an aqueous suspension including a major amount of collagen and a minor amount of one or more glycosaminoglycans ("GAGs") selected for its or their chemotactic effect on fibroblasts or endothelial cells.
Claim 2
Dependent Claim
41 words
A composition for use in promoting wound healing which is an aqueous suspension including a major amount of collagen and a minor amount of one or more glycosaminoglycans ("GAGs") selected for its or their chemotactic effect on fibroblasts or endothelial cells.
Claim 3
Dependent Claim
14 words
A composition according to Claim 1 wherein the suspension is in saline aqueous solution.
Claim 4
Dependent Claim
29 words
A composition according to Claim 2 wherein the solution is isotonic saline solution, and the collagen is present at a concentration of from 7 to 10 milligrams per millilitre.
Claim 5
Dependent Claim
30 words
A composition according to Claim 2 or Claim 3 wherein the GAG(s) is present or are in total present at a concentration of from 100 to 1000 micrograms per millilitre.
Claim 6
Dependent Claim
30 words
A composition according to Claim 2, Claim 3 or Claim 4 wherein the concentration of collagen is about 8.75 pg/ml and the concentration of the GAG(s) is about 280 Ilg/ml.
Claim 7
Dependent Claim
27 words
A composition according to any one of the preceding Claims wherein the GAG(s) is or are heparin (optionally in the form of its sulfate) and/or an alginate.
Claim 8
Dependent Claim
21 words
A composition according to any one of the preceding Claims wherein the ratio of collagen to GAG(s) is 25:1 to 35:1.
Claim 9
Dependent Claim
13 words
A dressing comprising a composition according to any one of the preceding Claims.
Claim 10
Dependent Claim
21 words
The use of an admixture of collagen and GAG(s) in the manufacture of a composition or dressing for promoting wound healing.
Claim 11
Dependent Claim
21 words
The use of an admixture of collagen and GAG(s) in the manufacture of a composition or dressing for promoting wound healing.
Claim 12
Independent Claim
44 words
A method of preparing a composition for use in promoting wound healing comprising forming an aqueous suspension including a major amount of collagen and a minor amount of one or more GAG's selected for its or their chemotactic effect on fibroblasts or endothelial cells.
Claim 13
Independent Claim
44 words
A method of preparing a composition for use in promoting wound healing comprising forming an aqueous suspension including a major amount of collagen and a minor amount of one or more GAG's selected for its or their chemotactic effect on fibroblasts or endothelial cells.
References Cited (Backward Citations)
No citation records indexed.
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