EP0042253B1
Expired / Lapsed
EP
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Fibrous collagenous hemostatic-adhesive web and method for its preparation
Assignee: Alcon Puerto Rico Inc
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Filing: 1981-06-10
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Granted: 1985-10-09
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Expires: 2001-06-10
Abstract
Abstract A fibrous, velvet-like, non-woven web having hemostatic and adhesive properties adapted to seal a wound comprising fibers of collagen or an ionizable, water-insoluble, partial salt of collagen. The web is formed by slurrying the fibers, which have hemostatic and adhesive properties, in an aqueous liquid, introducing a predetermined amount of slurry into a tray and freeze drying the slurry.
Inventors
- 👤 Fred Albert Serravallo
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 13:45
CPC Classifications
D; D21; D21H; D21H13/00; D21H13/10; D21H13/28; D21H13/34; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L24/00; A61L24/04; A61L24/10; A61L24/102; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0033; D21H5/00; D21H5/12; D21H5/1209; A61L2400/00; A61L2400/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
146 words
A method of forming a velvet-like, hemostat-adhesive, fibrous, non-woven web dressing for severed biological, surfaces the dressing being formed of hemostat-adhesive fibers consisting essentially of collagen or an ionizable, water-insoluble, partial salt of collagen containing from 50 to 90% of the theoretical stoichiometric amount of ionizable acid, the fibers having been subjected to deaggregation to impart self-adherent properties to the fibers, characterized by the steps of preparing a slurry of the collagen fibers, after deaggregation, in an aqueous liquid, the slurry containing from 0.5 to 3.5% fibers, by weight, introducing the slurry into a freeze-drier tray, in an amount sufficient to produce webs having a thickness from 2 to 10.2 mm and a basis weight of 50 to 250 g . m- 2 and freeze drying the slurry to give a dressing which, when placed on a wound and wet with blood, self-adheres to the wound.
Claim 2
Independent Claim
146 words
A method of forming a velvet-like, hemostat-adhesive, fibrous, non-woven web dressing for severed biological, surfaces the dressing being formed of hemostat-adhesive fibers consisting essentially of collagen or an ionizable, water-insoluble, partial salt of collagen containing from 50 to 90% of the theoretical stoichiometric amount of ionizable acid, the fibers having been subjected to deaggregation to impart self-adherent properties to the fibers, characterized by the steps of preparing a slurry of the collagen fibers, after deaggregation, in an aqueous liquid, the slurry containing from 0.5 to 3.5% fibers, by weight, introducing the slurry into a freeze-drier tray, in an amount sufficient to produce webs having a thickness from 2 to 10.2 mm and a basis weight of 50 to 250 g . m- 2 and freeze drying the slurry to give a dressing which, when placed on a wound and wet with blood, self-adheres to the wound.
Claim 3
Dependent Claim
20 words
The method as defined in claim 1 characterized in that the slurry medium is a mixture of water and ethanol.
Claim 4
Dependent Claim
20 words
The method as defined in claim 2, characterized in that the slurry contains from 0.5 to 2.5% fibers, by weight.
Claim 5
Independent Claim
17 words
The method as defined in any preceding claim characterized in that the fibers consist essentially of collagen.
Claim 6
Independent Claim
36 words
The method as defined in any preceding claim characterized in that the fibers consist essentially of an ionizable, water-insoluble, partial salt of collagen containing from 60 to 85% of the theoretical stoichiometric amount of ionizable acid.
Claim 7
Dependent Claim
24 words
The method as defined in claim 5, characterized in that the fibers consist essentially of an ionizable, water-insoluble, partial hydrogen chloride salt of collagen.
Claim 8
Independent Claim
36 words
The method as defined in any preceding claim characterized in that the slurry is frozen at a temperature of -40°C and the frozen slurry dried at a temperature of 38--40°C under a pressure of 50 pm.
Claim 9
Dependent Claim
102 words
A hemostat-adhesive dressing for severed biological surfaces characterized by a fibrous, velvet-like, porous non-woven web consisting essentially of hemostat-adhesive fibers of collagen or an ionizable, water-insoluble partial salt of collagen containing from 50 to 90% of the theoretical stoichiometric amount of ionizable acid and having a thickness of from 2 to 10.2 mm, a basis weight of from 25 to 250 g per sqm and a tensile strength of from 20 to 900 gms per 12.7 mm width, which is formed by the method of claim 1 and which, when placed on a wound and wet with blood, self-adheres to the wound.
Claim 10
Dependent Claim
82 words
A hemostat-adhesive dressing as defined in claim 8 characterized in that the web has a stiffness factor of from 30 to 85, measured by maintaining 1.9 cmx7.9 cm strips wrapped round a glass tube 2.54 cm in diameter for 24 hours at room temperature (22°C) and a relative humidity of about 50%, releasing the strips, allowing them to uncurl under their own weight on a horizontal surface and measuring the angle between the horizontal surface and the uncurled ends of the strips.
Claim 11
Dependent Claim
102 words
A hemostat-adhesive dressing as defined in claim 8 or claim 9 characterized in that the web consists essentially of fibers of collagen and the' web has a water holding capacity of 5 to 10 grams of water per gram of web, measured by weighing a 0.3 g sample, placing it in a basket of a 17.75 cmx17.75 cm piece of cheesecloth, immersing the basket containing the sample and an identical empty basket in distilled water for 60 seconds, allowing the baskets to drain without shaking, weighing the wet basket and calculating the water holding capacity of the sample from these measured weights.
Claim 12
Dependent Claim
54 words
A hemostat-adhesive dressing as defined in claim 8 or claim 9 characterized in that the web consists essentially of fibers of an ionizable, water-insoluble partial salt of collagen and the web has a water holding capacity, measured as defined in claim 10, of from 20 to 35 grams of water per gram of wet.
Claim 13
Dependent Claim
116 words
A hemostat-adhesive dressing as defined in claim 9 characterized in that the web consists essentially of hemostat-adhesive fibers of collagen or an ionizable, water-insoluble partial salt of collagen containing from 60 to 85% of the theoretical stoichiometric amount of ionizable acid, the web having a thickness of from 2.5 to 7 mm, a basis weight of from 80 to 200 gms per sqm, a tensile strength of from 30 to 450 gms per 12.7 mm width, a stiffness factor, measured as defined in claim 9, of from 35 to 75 and a porosity such that 75% of the pores have diameters not exceeding 10 to 11 µm and all pores have diameters not exceeding 15 um.
Claim 14
Dependent Claim
66 words
A hemostat-adhesive dressing as defined in claim 12 characterized in that the web consists essentially of fibers of an ionizable, water-insoluble partial hydrogen chloride salt of collagen containing from 60 to 85% of the theoretical stoichiometric amount of hydrogen chloride and the web has a water holding capacity, measured as defined in claim 10, of from 20 to 35 grams of water per gram of web.
References Cited (Backward Citations)
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