US4774227A
Expired / Lapsed
US
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Collagen compositions for bone repair containing autogeneic marrow
Assignee: Ramot at Tel Aviv University Ltd
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Filing: 1986-02-14
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Granted: 1988-09-27
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Expires: 2006-02-14
Abstract
Abstract A composition which combines autogenic bone marrow with a suspension of purified atelopeptide reconstituted collagen is used to repair bone defects in mammals.
Inventors
- 👤 Karl A. Piez
- 👤 Shlomo Weintraub
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:18
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/3604; A61L27/3608; A61F; A61F2/00; A61F2/02; A61F2/28; A61K; A61K35/00; A61K35/12; A61K35/28; A61L27/14; A61L27/22; A61L27/24; A61L27/3641; A61L27/3645; A61L27/365; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
26 words
A method to mediate the repair of bone defects which comprises placing into said defect a composition containing reconstituted fibrillar atelopeptide collagen and autogeneic bone marrow.
Claim 2
Independent Claim
26 words
A method to mediate the repair of bone defects which comprises placing into said defect a composition containing reconstituted fibrillar atelopeptide collagen and autogeneic bone marrow.
Claim 3
Dependent Claim
25 words
The method of claim 1 wherein the collagen is supplied as an aqueous suspension containing 10-100 mg/ml and is 50%-95% of said composition by volume.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the collagen is of xenogeneic origin.
Claim 5
Dependent Claim
12 words
The method of claim 3 wherein the collagen is of bovine origin.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein the composition is injected into the defect.
Claim 7
Dependent Claim
28 words
A composition for the repair of bone defects which comprises (a) an aqueous suspensions containing 10-100 mg/ml of reconstituted fibrillar atelopeptide purified collagen, and (b) autogeneic bone marrow.
Claim 8
Dependent Claim
28 words
A composition for the repair of bone defects which comprises (a) an aqueous suspensions containing 10-100 mg/ml of reconstituted fibrillar atelopeptide purified collagen, and (b) autogeneic bone marrow.
Claim 9
Dependent Claim
16 words
The composition of claim 6 wherein the collagen suspension comprises 50%-95% by volume of the composition.
Claim 10
Dependent Claim
10 words
The composition of claim 6 which is an injectable suspension.
References Cited (Backward Citations)
US4347234A
Cited
US4394370A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-27 | 1992-03-28 | 1992-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-27 | 1996-03-28 | 1996-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-27 | 2000-03-28 | 2000-09-27 | $7700.00 | Window Closed / Lapsed |