US4164559A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Collagen drug delivery device
Assignee: VISION 2000 TECHNOLOGIES Inc
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Filing: 1977-09-21
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Granted: 1979-08-14
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Expires: 1997-09-21
Abstract
Abstract Chemically-modified collagen membrane prepared at physiologic pH and soluble thereat provides a carrier for ophthalmic medication leaving no removable material after drug release.
Inventors
- 👤 Teruo Miyata
- 👤 Albert L. Rubin
- 👤 Kurt H. Stenzel
- 👤 Michael W. Dunn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0048; A61K9/0051
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
56 words
An ophthalmic drug delivery system comprising (a) an enzyme-extracted, chemically-modified collagen thin membrane carrier selected from the group consisting of esterified collagen and acylated collagen and having a pH in the range of 5.5-9.0 whereby the carrier is soluable in the tear fluid under physiologic conditions, and (b) an ophthalmically active drug incorporated into said carrier.
Claim 2
Dependent Claim
56 words
An ophthalmic drug delivery system comprising (a) an enzyme-extracted, chemically-modified collagen thin membrane carrier selected from the group consisting of esterified collagen and acylated collagen and having a pH in the range of 5.5-9.0 whereby the carrier is soluable in the tear fluid under physiologic conditions, and (b) an ophthalmically active drug incorporated into said carrier.
Claim 3
Dependent Claim
12 words
The system of claim 1 in which the carrier is esterified collagen.
Claim 4
Dependent Claim
12 words
The system of claim 1 in which the carrier is acylated collagen.
Claim 5
Dependent Claim
31 words
The system of claim 1 in which the drug is at least one drug selected from the group consisting of pilocarpine, dexamethazone, gentamycin, sulfapyridazine, atropine, dicain, neomycin, kanamycin, tetracycline and idoxuridine.
Claim 6
Dependent Claim
12 words
The system of claim 2 in which the carrier is methylated collagen.
Claim 7
Dependent Claim
12 words
The system of claim 3 in which the carrier is succinylated collagen.
Claim 8
Independent Claim
77 words
A method for preparing an ophthalmic drug delivery device soluable at physiologic pH and at body temperature which comprises forming a gel from enzyme-extracted, chemically-modified collagen selected from the group consisting of esterified collagen and acylated collagen, adding an ophthalmically-active drug to the gel, adjusting the pH of the gel to a range of 5.5 to 9.0, de-airating and drying the drug-containing gel to form a thin membrane thereof, and shaping the membrane to ocular insert form.
Claim 9
Independent Claim
77 words
A method for preparing an ophthalmic drug delivery device soluable at physiologic pH and at body temperature which comprises forming a gel from enzyme-extracted, chemically-modified collagen selected from the group consisting of esterified collagen and acylated collagen, adding an ophthalmically-active drug to the gel, adjusting the pH of the gel to a range of 5.5 to 9.0, de-airating and drying the drug-containing gel to form a thin membrane thereof, and shaping the membrane to ocular insert form.
Claim 10
Dependent Claim
19 words
The method of claim 7 in which the collagen is succinylated collagen and in which the drug is pilocarpine.
Claim 11
Dependent Claim
19 words
The method of claim 7 in which the collagen is methylated collagen and in which the drug is dexamethazone.
References Cited (Backward Citations)
JPS5042025A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-13 | 1983-02-12 | 1983-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-13 | 1987-02-12 | 1987-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-13 | 1991-02-12 | 1991-08-14 | $7700.00 | Window Closed / Lapsed |