US4238480A
Expired / Lapsed
US
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Method for preparing an improved hemostatic agent and method of employing the same
Assignee: SUPERSTAT Corp
•
Filing: 1978-05-19
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Granted: 1980-12-09
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Expires: 1998-05-19
Abstract
Abstract An improved hemostatic agent is made by treating collagen or collagen-like substance to render the surface charge thereof effectively more positive. The thusly modified substance is employed to control or terminate bleeding.
Inventors
- 👤 Philip N. Sawyer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:45
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/78; A; A61; A61L; A61L24/00; A61L24/001; A61L24/0036; A61L24/04; A61L24/10; A61L24/104; A61L26/00; A61L26/0009; A61L26/0028; A61L26/0038; A61L26/0061; A61L26/0085; A61K; A61K38/00; A61L2400/00; A61L2400/04; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
58 words
A method comprising modifying one of the group consisting of collagen substance or a collagen-like substance by dissolving the substance in water and modifying the thusly dissolved substance to render the surface charge thereof effectively more positive than prior to modification, and freezing and drying the thusly modified substance and applying the thusly modified substance to control bleeding.
Claim 2
Independent Claim
58 words
A method comprising modifying one of the group consisting of collagen substance or a collagen-like substance by dissolving the substance in water and modifying the thusly dissolved substance to render the surface charge thereof effectively more positive than prior to modification, and freezing and drying the thusly modified substance and applying the thusly modified substance to control bleeding.
Claim 3
Dependent Claim
15 words
A method as claimed in claim 1 wherein the substance is modified by non-covalent modification.
Claim 4
Dependent Claim
12 words
A method as claimed in claim 2 wherein the substance is lyophilized.
Claim 5
Independent Claim
41 words
A method comprising modifying one of the group consisting of collagen substance or a collagen-like substance to render the surface charge thereof effectively more positive, and applying the thusly modified substance to control bleeding, the substance being modified by covalent modification.
Claim 6
Independent Claim
41 words
A method comprising modifying one of the group consisting of collagen substance or a collagen-like substance to render the surface charge thereof effectively more positive, and applying the thusly modified substance to control bleeding, the substance being modified by covalent modification.
Claim 7
Dependent Claim
12 words
A method as claimed in claim 4 wherein the substance is lyophilized.
Claim 8
Dependent Claim
9 words
A hemostatic agent prepared as claimed in claim 1.
Claim 9
Dependent Claim
9 words
A hemostatic agent prepared as claimed in claim 3.
Claim 10
Dependent Claim
9 words
A hemostatic agent prepared as claimed in claim 5.
Claim 11
Dependent Claim
18 words
A method as claimed in claim 3 wherein the substance is gelatin which is treated with hydrochloric acid.
Claim 12
Dependent Claim
17 words
A method as claimed in claim 5 wherein the substance is gelatin which is treated with ethylenediamine.
Claim 13
Dependent Claim
19 words
A method as claimed in claim 5 wherein the substance is gelatin which is treated with NH 4 Cl.
Claim 14
Dependent Claim
17 words
A method as claimed in claim 5 wherein the substance is gelatin which is treated with HCl.
Claim 15
Independent Claim
54 words
A method of preparing a hemostatic agent comprising modifying one of the groups consisting of collagen substance or a collagen-like substance by dissolving the substance in water and modifying the thusly dissolved substance to render the surface charge thereof effectively more positive than prior to modification, and freezing and drying the thusly modified substance.
Claim 16
Independent Claim
54 words
A method of preparing a hemostatic agent comprising modifying one of the groups consisting of collagen substance or a collagen-like substance by dissolving the substance in water and modifying the thusly dissolved substance to render the surface charge thereof effectively more positive than prior to modification, and freezing and drying the thusly modified substance.
Claim 17
Dependent Claim
15 words
A method as claimed in claim 13 wherein the substance is modified by non-covalent modification.
Claim 18
Dependent Claim
12 words
A method as claimed in claim 14 wherein the substance is lyophilized.
Claim 19
Independent Claim
37 words
A method of preparing a hemostatic agent comprising modifying one of the groups consisting of collagen substance or a collagen-like substance to render the surface charge thereof effectively more positive, the substance being modified by covalent modification.
Claim 20
Independent Claim
37 words
A method of preparing a hemostatic agent comprising modifying one of the groups consisting of collagen substance or a collagen-like substance to render the surface charge thereof effectively more positive, the substance being modified by covalent modification.
Claim 21
Dependent Claim
12 words
A method as claimed in claim 16 wherein the substance is lyophilized.
Claim 22
Dependent Claim
9 words
A hemostatic agent prepared as claimed in claim 13.
Claim 23
Dependent Claim
9 words
A hemostatic agent prepared as claimed in claim 15.
Claim 24
Dependent Claim
9 words
A hemostatic agent prepared as claimed in claim 17.
Claim 25
Dependent Claim
18 words
A method as claimed in claim 15 wherein the substance is gelatin which is treated with hydrochloric acid.
Claim 26
Dependent Claim
17 words
A method as claimed in claim 17 wherein the substance is gelatin which is treated with ethylenediamine.
Claim 27
Dependent Claim
19 words
A method as claimed in claim 17 wherein the substance is gelatin which is treated with NH 4 Cl.
Claim 28
Dependent Claim
17 words
A method as claimed in claim 17 wherein the substance is gelatin which is treated with HCl.
Claim 29
Dependent Claim
17 words
A method as claimed in claim 15 wherein the substance is gelatin which is treated with calcium.
Claim 30
Dependent Claim
18 words
A method as claimed in claim 25 wherein the calcium is used in the form of calcium chloride.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-09 | 1984-06-09 | 1984-12-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-09 | 1988-06-09 | 1988-12-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-09 | 1992-06-09 | 1992-12-09 | $7700.00 | Window Closed / Lapsed |