US6585764B2
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stent with therapeutically active dosage of rapamycin coated thereon
Assignee: Cordis US Corp
•
Filing: 2001-06-04
•
Granted: 2003-07-01
•
Expires: 2021-06-04
Abstract
Abstract Delivery of rapamycin locally, particularly from intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This invention also facilitates the performance of the stent in inhibiting restenosis.
Inventors
- 👤 Carol Wright
- 👤 Gerard H. Llanos
- 👤 Ronald Rakos
- 👤 Kristen King
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 16:01
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/90; A61F2/91; A61F2/915; A61L; A61L31/00; A61L31/08; A61L31/10; A61L31/14; A61L31/16; A61P; A61P9/00; A61F2002/91533; A61F2002/91541; A61F2002/9155; A61F2002/91558; A61F2250/00; A61F2250/0058; A61F2250/0067; A61F2250/0068; A61L2300/00; A61L2300/40; A61L2300/416; A61L2300/60; A61L2300/606
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
25 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin; and said coating applied to said stent.
Claim 2
Dependent Claim
25 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin; and said coating applied to said stent.
Claim 3
Dependent Claim
10 words
The stent of claim 1 wherein the stent is dip-coated.
Claim 4
Dependent Claim
13 words
The stent of claim 1 wherein the stent is sprayed with said coating.
Claim 5
Dependent Claim
29 words
A stent having a coating containing rapamycin or its analogs, wherein said rapamycin or said analogs are contained in the coating at a weight percentage of 0.0001% to 30%.
Claim 6
Dependent Claim
29 words
A stent having a coating containing rapamycin or its analogs, wherein said rapamycin or said analogs are contained in the coating at a weight percentage of 0.0001% to 30%.
Claim 7
Dependent Claim
16 words
The stent of claim 4 wherein a polymer is mixed to the rapamycin or its analogs.
Claim 8
Dependent Claim
16 words
The stent of claim 4 wherein a polymer is bound to the rapamycin or its analogs.
Claim 9
Dependent Claim
22 words
The stent of claim 4 wherein the rapamycin or its analogs is entrapped on the surface of the stent by a polymer.
Claim 10
Dependent Claim
57 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; wherein the polymer is biocompatible and degradable; and wherein the polymer is chosen from: lactone-based polyesters, lactone-based copolyesters; polyanhydrides; polyaminoacids; polysaccharides; polyphosphazenes; poly(ether-ester) copolymers, and blends of such polymers.
Claim 11
Dependent Claim
57 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; wherein the polymer is biocompatible and degradable; and wherein the polymer is chosen from: lactone-based polyesters, lactone-based copolyesters; polyanhydrides; polyaminoacids; polysaccharides; polyphosphazenes; poly(ether-ester) copolymers, and blends of such polymers.
Claim 12
Dependent Claim
50 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; and wherein the polymer is chosen from: lactone-based polyesters, lactone-based copolyesters; polyanhydrides; polyaminoacids; polysaccharides; polyphosphazenes; poly(ether-ester) copolymers, and blends of such polymers.
Claim 13
Dependent Claim
50 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; and wherein the polymer is chosen from: lactone-based polyesters, lactone-based copolyesters; polyanhydrides; polyaminoacids; polysaccharides; polyphosphazenes; poly(ether-ester) copolymers, and blends of such polymers.
Claim 14
Dependent Claim
49 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; wherein the polymer is nonabsorbable; and wherein the polymer is chosen from: polydimethylsiolxane; poly(ethylene)vinylacetate; poly(hydroxy)ethylmethylmethacrylate, polyvinyl pyrrolidone; polytetrafluoroethylene; and cellulose esters.
Claim 15
Dependent Claim
49 words
A stent having a coating containing rapamycin, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; wherein the polymer is nonabsorbable; and wherein the polymer is chosen from: polydimethylsiolxane; poly(ethylene)vinylacetate; poly(hydroxy)ethylmethylmethacrylate, polyvinyl pyrrolidone; polytetrafluoroethylene; and cellulose esters.
Claim 16
Dependent Claim
47 words
A stent having a coating containing rapamycin or its analogs, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; and wherein the polymer is chosen from: polydimethylsiolxane; poly(ethylene)vinylacetate; poly(hydroxy)ethylmethylmethacrylate, polyvinyl pyrrolidone; polytetrafluoroethylene; and cellulose esters.
Claim 17
Dependent Claim
47 words
A stent having a coating containing rapamycin or its analogs, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; and wherein the polymer is chosen from: polydimethylsiolxane; poly(ethylene)vinylacetate; poly(hydroxy)ethylmethylmethacrylate, polyvinyl pyrrolidone; polytetrafluoroethylene; and cellulose esters.
Claim 18
Dependent Claim
98 words
A stent having a coating containing rapamycin or its analogs, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; and further comprising: a generally thin walled cylinder, said cylinder containing a plurality of generally solid struts, said applied to said strut, and a channel formed in at least one of said struts, said channel having a closed perimeter on all sides and an open top, and said channel smaller in all dimensions than said strut, said channel containing a reservoir of said rapamycin coating applied therein.
Claim 19
Dependent Claim
98 words
A stent having a coating containing rapamycin or its analogs, said coating formed from a polymer mixed carrier containing the rapamycin or its analogs; and said coating applied to said stent; and further comprising: a generally thin walled cylinder, said cylinder containing a plurality of generally solid struts, said applied to said strut, and a channel formed in at least one of said struts, said channel having a closed perimeter on all sides and an open top, and said channel smaller in all dimensions than said strut, said channel containing a reservoir of said rapamycin coating applied therein.
Claim 20
Dependent Claim
35 words
A stent having a coating containing rapamycin or its analogs, wherein said rapamycin or said analogs are contained in the coating at a weight percentage of 0.0001% to 30%, wherein the coating is a polymer.
Claim 21
Dependent Claim
35 words
A stent having a coating containing rapamycin or its analogs, wherein said rapamycin or said analogs are contained in the coating at a weight percentage of 0.0001% to 30%, wherein the coating is a polymer.
Claim 22
Dependent Claim
16 words
The stent of claim 13 wherein said polymer is mixed to the rapamycin or its analogs.
Claim 23
Dependent Claim
16 words
The stent of claim 4 wherein said polymer is bound to the rapamycin or its analogs.
Claim 24
Dependent Claim
22 words
The stent of claim 13 wherein the rapamycin or its analogs is entrapped on the surface of the stent by said polymer.
Claim 25
Dependent Claim
26 words
A stent containing a polymer and rapamycin or its analogs wherein said rapamycin or its analogs are contained in a therapeutically beneficial amount to combat restenosis.
Claim 26
Dependent Claim
26 words
A stent containing a polymer and rapamycin or its analogs wherein said rapamycin or its analogs are contained in a therapeutically beneficial amount to combat restenosis.
Claim 27
Dependent Claim
16 words
The stent of claim 17 wherein said polymer is mixed to the rapamycin or its analogs.
Claim 28
Dependent Claim
16 words
The stent of claim 17 wherein said polymer is bound to the rapamycin or its analogs.
Claim 29
Dependent Claim
22 words
The stent of claim 17 wherein the rapamycin or its analogs is entrapped on the surface of the stent by said polymer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2006-06-30 | 2006-12-30 | 2007-07-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2010-06-30 | 2010-12-30 | 2011-07-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2014-06-30 | 2014-12-30 | 2015-07-01 | $7700.00 | Window Closed / Lapsed |