EP0850651A2
Expired / Lapsed
EP
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Method of applying drug-release coatings
Assignee: Schneider USA Inc
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Filing: 1997-12-15
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Granted: —
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Expires: 2017-12-15
Abstract
Abstract The invention is directed to a method of applying drug-release coatings whereby a polymer can be dissolved in a first solvent (solvent A) to form a polymer system and a drug can be dissolved or suspended in a second solvent (solvent B) to form a drug system. The coating or layer of coating so formed comprises a substantially uniform combination of the drug and polymer. Solvent B can be the same as or different than solvent A. The coating can be applied on a stent body by separately spraying or dipping the polymer system and the drug system onto the devices. The coating can be accomplished by either applying the polymer and drug systems sequentially or simultaneously. In certain embodiments, a drug can be suspended in solvent B. In some cases, three or more systems can be utilized. For instance, a third system containing pure solvent A or B can smooth the coating surface, if the solvent of the third spraying system is compatible with the polymer matrix.
Inventors
- 👤 Ni Ding
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-25 13:28
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6957; A61L31/00; A61L31/04; A61L31/043; A61L31/047; A61L31/08; A61L31/10; A61L31/14; A61L31/16; A61F; A61F2/00; A61F2/82; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/60; A61L2300/606; A61L2300/608; A61L2420/00; A61L2420/02; B; B05; B05B; B05B13/00; B05B13/02; B05B13/04; B05B13/0442
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
124 words
A method of making a medical device having at least
a portion for insertion or implantation into the body of a
patient, wherein the portion has a surface which is adapted
for exposure to body tissue of the patient and wherein at
least a part of the surface is covered with a coating, to
release at least one biologically active material therefrom,
the method comprising: a) applying a polymer system substantially free of a
biologically active material comprising a polymer and a first
solvent to the surface, and b) applying a drug system substantially free of a
polymer comprising a biologically active material and a
second solvent to the surface;
wherein said method forms a composite of the polymer and the
biologically active material.
Claim 2
Dependent Claim
11 words
The method of claim 1 wherein the composite is
substantially homogeneous.
Claim 3
Dependent Claim
12 words
The method of claim 1 wherein steps (a) and (b) are
repeated.
Claim 4
Dependent Claim
12 words
The method of claim 1 wherein the medical device is
a stent.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein the stent is a self-expanding
stent.
Claim 6
Dependent Claim
15 words
The method of claim 1 wherein the first solvent and
second solvent are the same.
Claim 7
Dependent Claim
14 words
The method of claim 1 wherein the first solvent and
second solvent are different.
Claim 8
Dependent Claim
13 words
The method of claim 1 wherein the polymer is a
hydrophobic biostable elastomer.
Claim 9
Dependent Claim
30 words
The method of claim 1 wherein the elastomer is
selected from the group consisting of silicones,
polyurethanes, thermoplastic elastomers, ethylene vinyl
acetate copolymers, polyolefin elastomers, EPDM rubbers and
polyamide elastomers.
Claim 10
Dependent Claim
55 words
The method of claim 1 wherein the biologically
active material is selected from the group consisting of
antithrobotics, anticoagulants, antiplatelet agents,
thrombolytics, antiproliferatives, anti-inflammatories,
agents that inhibit hyperplasia, smooth muscle cell
inhibitors, antibiotics, growth factors, growth factor
inhibitors, cell adhesion inhibitors, cell adhesion promoters
and drugs that may enhance the formation of healthy
neointimal tissue.
Claim 11
Dependent Claim
17 words
The method of claim 1 wherein the polymer system or
drug system is applied by spray coating.
Claim 12
Dependent Claim
16 words
The method of claim 1 wherein the polymer system or
drug system is applied by dipping.
Claim 13
Dependent Claim
19 words
The method of claim 1 wherein the polymer system
and the drug system are applied simultaneously to the
surface.
Claim 14
Dependent Claim
19 words
The method of claim 1 wherein the polymer system
and the drug system are applied sequentially to the surface.
Claim 15
Dependent Claim
19 words
The method of claim 1 which further comprises
partially evaporating the first solvent prior to applying the
drug system.
Claim 16
Dependent Claim
16 words
The method of claim 1 wherein the biologically
active material is dissolved in the second solvent.
Claim 17
Dependent Claim
16 words
The method of claim 1 wherein the biologically
active material is suspended in the second solvent.
Claim 18
Dependent Claim
15 words
The method of claim 1 which further comprises
applying a solvent system to the surface.
Claim 19
Dependent Claim
27 words
The method of claim 1 which further comprises
applying a second drug system substantially free of a polymer
comprising a second biologically active material to the
surface.
Claim 20
Independent Claim
128 words
An apparatus 2 for covering at least part of a
surface of a medical device 8 with a coating, said apparatus 2 comprising: a) a mounting element 4 comprising at least one support
element 24 for mounting the device 8 to the apparatus 2 ; and b) a spray element 6 aligned with said mounting element 4 in a manner which allows the surface of the device 8 to be
sprayed, said spray element 6 comprising i) a structural support 14 and ii) first and second spray canisters 16 , 18 movably
mounted on said structural support 14 , wherein said
first canister 16 is fluidly connected to a first spray
dispenser 20 and said second canister 18 is fluidly
connected to a second spray dispenser 22 .
Claim 21
Dependent Claim
26 words
The apparatus 2 of claim 20 wherein gas supply
means 26 , 28 are connected to said first and second spray
dispensers 20 , 22 .
Claim 22
Dependent Claim
24 words
The apparatus 2 of claim 20 wherein said first and
second canisters 16 , 18 are fixed at a predetermined distance
from each other.
Claim 23
Dependent Claim
23 words
The apparatus 2 of claim 20 wherein said first and
second canisters 16 , 18 are capable of movement independent
of each other.
Claim 24
Dependent Claim
38 words
The apparatus 2 of claim 20 wherein said first and
second canisters 16 , 18 are movably mounted on said
structural support 14 in a manner which permits said
canisters 16 , 18 to move past one another.
Claim 25
Dependent Claim
19 words
The apparatus 2 of claim 20 which further comprises
a motor 10 for rotating said support element 24 .
References Cited (Backward Citations)
No citation records indexed.
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