US5800507A
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Intraluminal stent
Assignee: Medtronic Inc
•
Filing: 1995-04-27
•
Granted: 1998-09-01
•
Expires: 2015-04-27
Abstract
Abstract An intraluminal stent comprising fibrin is capable of reducing the incidence of restenosis at the site of vascular injury such as that produced by an angioplasty procedure.
Inventors
- 👤 Robert S. Schwartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:39
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61F; A61F2/00; A61F2/82; A61L31/04; A61L31/041; A61L31/043; A61L31/046; A61L31/047; A61L31/08; A61L31/10; A61L31/12; A61L31/125; A61L31/128; A61F2/0077; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/252; A61L2300/40; A61L2300/416; A61L2300/42; A61L2300/60; A61L2300/62; A61L2300/622; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 69
Claim 1
Independent Claim
64 words
An intraluminal device comprising: (a) means for percutaneous, transluminal delivery of a stent into a body lumen and through the body lumen to a portion of the body lumen having a luminal restriction; (b) a stent attached to said delivery means, the stent having preformed fibrin thereon; and (c) means for expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 2
Dependent Claim
64 words
An intraluminal device comprising: (a) means for percutaneous, transluminal delivery of a stent into a body lumen and through the body lumen to a portion of the body lumen having a luminal restriction; (b) a stent attached to said delivery means, the stent having preformed fibrin thereon; and (c) means for expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 3
Dependent Claim
15 words
The device of claim 1 wherein the stent has an underlying structure of a metal.
Claim 4
Dependent Claim
29 words
The device of claim 1 wherein said delivery means comprises a catheter with a balloon at a distal end, the stent affixed to an outside surface of the balloon.
Claim 5
Dependent Claim
14 words
The device of claim 2 wherein the metal is embedded in the preformed fibrin.
Claim 6
Dependent Claim
18 words
The device of claim 2 wherein the preformed fibrin is formed into a film affixed to the metal.
Claim 7
Dependent Claim
14 words
The device of claim 1 wherein the preformed fibrin also includes a therapeutic substance.
Claim 8
Dependent Claim
13 words
The device of claim 6 wherein the therapeutic substance is incorporated in microcapsules.
Claim 9
Dependent Claim
25 words
The device of claim 6 wherein the therapeutic substance is selected from the group consisting of anticoagulant drugs, antiplatelet drugs, antimetabolite drugs and antimitotic drugs.
Claim 10
Independent Claim
67 words
A method for preventing restenosis in a body lumen treated to open a luminal restriction, the method comprising the steps of: (a) delivering a stent having preformed fibrin thereon percutaneously and transluminally into a body lumen and through the body lumen to the portion of the body lumen having the luminal restriction; and (b) expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 11
Independent Claim
67 words
A method for preventing restenosis in a body lumen treated to open a luminal restriction, the method comprising the steps of: (a) delivering a stent having preformed fibrin thereon percutaneously and transluminally into a body lumen and through the body lumen to the portion of the body lumen having the luminal restriction; and (b) expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 12
Dependent Claim
14 words
The method of claim 9 wherein the preformed fibrin also includes a therapeutic substance.
Claim 13
Dependent Claim
13 words
The method of claim 10 wherein the therapeutic substance is incorporated in microcapsules.
Claim 14
Dependent Claim
25 words
The method of claim 10 wherein the therapeutic substance is selected from the group consisting of anticoagulant drugs, antiplatelet drugs, antimetabolite drugs and antimitotic drugs.
Claim 15
Dependent Claim
80 words
An intraluminal device comprising: (a) means for percutaneous, transluminal delivery of a stent into a body lumen and through the body lumen to a portion of the body lumen having a luminal restriction; (b) a stent attached to said delivery means, the stent having preformed fibrin thereon, the preformed fibrin made with a coagulating protein in which residual coagulating protein has been neutralized; and (c) means for expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 16
Dependent Claim
80 words
An intraluminal device comprising: (a) means for percutaneous, transluminal delivery of a stent into a body lumen and through the body lumen to a portion of the body lumen having a luminal restriction; (b) a stent attached to said delivery means, the stent having preformed fibrin thereon, the preformed fibrin made with a coagulating protein in which residual coagulating protein has been neutralized; and (c) means for expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 17
Dependent Claim
15 words
The device of claim 13 wherein the stent has an underlying structure of a metal.
Claim 18
Dependent Claim
12 words
The device of claim 14 wherein the metal is a deformable metal.
Claim 19
Dependent Claim
12 words
The device of claim 14 wherein the metal is a resilient metal.
Claim 20
Dependent Claim
15 words
The device of claim 13 wherein the stent has an underlying structure of a polymer.
Claim 21
Dependent Claim
29 words
The device of claim 13 wherein said delivery means comprises a catheter with a balloon at a distal end, the stent affixed to an outside surface of the balloon.
Claim 22
Dependent Claim
15 words
The device of claim 13 wherein the preformed fibrin is intermixed with a polymeric material.
Claim 23
Dependent Claim
14 words
The device of claim 14 wherein the metal is embedded in the preformed fibrin.
Claim 24
Dependent Claim
18 words
The device of claim 14 wherein the preformed fibrin is formed into a film affixed to the metal.
Claim 25
Dependent Claim
20 words
The device of claim 13 wherein the coagulating protein is selected from the group consisting of thrombin, reptilase and ancrod.
Claim 26
Dependent Claim
18 words
The device of claim 13 wherein the residual coagulating protein has been neutralized by an irreversible coagulation inhibitor.
Claim 27
Dependent Claim
22 words
The device of claim 13 wherein the irreversible coagulation inhibitor is selected from the group consisting of hirudin and D-phenylalanyl-propyl-arginine chloromethyl ketone.
Claim 28
Dependent Claim
16 words
The device of claim 13 wherein the residual coagulating protein has been neutralized by an anti-coagulant.
Claim 29
Dependent Claim
10 words
The device of claim 25 wherein the anti-coagulant is heparin.
Claim 30
Dependent Claim
14 words
The device of claim 13 wherein the preformed fibrin also includes a therapeutic substance.
Claim 31
Dependent Claim
13 words
The device of claim 27 wherein the therapeutic substance is incorporated in microcapsules.
Claim 32
Dependent Claim
25 words
The device of claim 27 wherein the therapeutic substance is selected from the group consisting of anticoagulant drugs, antiplatelet drugs, antimetabolite drugs and antimitotic drugs.
Claim 33
Independent Claim
83 words
A method for preventing restenosis in a body lumen treated to open a luminal restriction, the method comprising the steps of: (a) delivering a stent having preformed fibrin thereon percutaneously and transluminally into a body lumen and through the body lumen to the portion of the body lumen having the luminal restriction, the preformed fibrin made with a coagulating protein in which residual coagulating protein has been neutralized; and (b) expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 34
Independent Claim
83 words
A method for preventing restenosis in a body lumen treated to open a luminal restriction, the method comprising the steps of: (a) delivering a stent having preformed fibrin thereon percutaneously and transluminally into a body lumen and through the body lumen to the portion of the body lumen having the luminal restriction, the preformed fibrin made with a coagulating protein in which residual coagulating protein has been neutralized; and (b) expanding the stent and preformed fibrin thereon into contact with the body lumen.
Claim 35
Dependent Claim
20 words
The method of claim 30 wherein the coagulating protein is selected from the group consisting of thrombin, reptilase and ancrod.
Claim 36
Dependent Claim
18 words
The method of claim 30 wherein the residual coagulating protein has been neutralized by an irreversible coagulation inhibitor.
Claim 37
Dependent Claim
22 words
The method of claim 32 wherein the irreversible coagulation inhibitor is selected from the group consisting of hirudin and D-phenylalanyl-propyl-arginine chloromethyl ketone.
Claim 38
Dependent Claim
16 words
The method of claim 30 wherein the residual coagulating protein has been neutralized by an anti-coagulant.
Claim 39
Dependent Claim
10 words
The method of claim 34 wherein the anti-coagulant is heparin.
Claim 40
Dependent Claim
14 words
The method of claim 30 wherein the preformed fibrin also includes a therapeutic substance.
Claim 41
Dependent Claim
13 words
The method of claim 36 wherein the therapeutic substance is incorporated in microcapsules.
Claim 42
Dependent Claim
25 words
The method of claim 36 wherein the therapeutic substance is selected from the group consisting of anticoagulant drugs, antiplatelet drugs, antimetabolite drugs and antimitotic drugs.
Claim 43
Dependent Claim
77 words
An intraluminal device comprising: (a) means for percutaneous, transluminal delivery of a stent into a body lumen and through the body lumen to a portion of the body lumen having a luminal restriction; (b) a stent attached to said delivery means, the stent having a preform of fibrin intermixed with at least one polymeric material thereon; and (c) means for expanding the stent and preform of fibrin and polymeric material thereon into contact with the body lumen.
Claim 44
Dependent Claim
77 words
An intraluminal device comprising: (a) means for percutaneous, transluminal delivery of a stent into a body lumen and through the body lumen to a portion of the body lumen having a luminal restriction; (b) a stent attached to said delivery means, the stent having a preform of fibrin intermixed with at least one polymeric material thereon; and (c) means for expanding the stent and preform of fibrin and polymeric material thereon into contact with the body lumen.
Claim 45
Dependent Claim
15 words
The device of claim 39 wherein the stent has an underlying structure of a metal.
Claim 46
Dependent Claim
12 words
The device of claim 40 wherein the metal is a deformable metal.
Claim 47
Dependent Claim
12 words
The device of claim 40 wherein the metal is a resilient metal.
Claim 48
Dependent Claim
15 words
The device of claim 39 wherein the stent has an underlying structure of a polymer.
Claim 49
Dependent Claim
29 words
The device of claim 39 wherein said delivery means comprises a catheter with a balloon at a distal end, the stent affixed to an outside surface of the balloon.
Claim 50
Dependent Claim
12 words
The device of claim 39 wherein the polymer is a biostable polymer.
Claim 51
Dependent Claim
12 words
The device of claim 45 wherein the biostable polymer is a polyurethane.
Claim 52
Dependent Claim
12 words
The device of claim 39 wherein the polymer is a bioabsorbable polymer.
Claim 53
Dependent Claim
21 words
The device of claim 47 wherein the bioabsorbable polymer is selected from the group consisting of polyphosphate ester and polyhydroxybutyric valerate.
Claim 54
Dependent Claim
14 words
The device of claim 39 wherein the polymer is a co-polymer with the fibrin.
Claim 55
Dependent Claim
17 words
The device of claim 40 wherein the metal is embedded in the preform of fibrin and polymer.
Claim 56
Dependent Claim
21 words
The device of claim 40 wherein the preform of fibrin and polymer are formed into a film affixed to the metal.
Claim 57
Dependent Claim
17 words
The device of claim 39 wherein the preform of fibrin and polymer also includes a therapeutic substance.
Claim 58
Dependent Claim
13 words
The device of claim 52 wherein the therapeutic substance is incorporated in microcapsules.
Claim 59
Dependent Claim
25 words
The device of claim 52 wherein the therapeutic substance is selected from the group consisting of anticoagulant drugs, antiplatelet drugs, antimetabolite drugs and antimitotic drugs.
Claim 60
Independent Claim
83 words
A method for preventing restenosis in a portion of a body lumen treated to open a luminal restriction, the method comprising the steps of: (a) delivering a stent having a preform of fibrin intermixed with at least one polymeric material thereon percutaneously and transluminally into a body lumen and through the body lumen to the portion of the body lumen treated to open the luminal restriction; and (b) expanding the stent and the preform of fibrin thereon into contact with the body lumen.
Claim 61
Independent Claim
83 words
A method for preventing restenosis in a portion of a body lumen treated to open a luminal restriction, the method comprising the steps of: (a) delivering a stent having a preform of fibrin intermixed with at least one polymeric material thereon percutaneously and transluminally into a body lumen and through the body lumen to the portion of the body lumen treated to open the luminal restriction; and (b) expanding the stent and the preform of fibrin thereon into contact with the body lumen.
Claim 62
Dependent Claim
16 words
The method of claim 55 wherein the at least one polymeric material is a biostable polymer.
Claim 63
Dependent Claim
12 words
The method of claim 56 wherein the biostable polymer is a polyurethane.
Claim 64
Dependent Claim
12 words
The method of claim 55 wherein the polymer is a bioabsorbable polymer.
Claim 65
Dependent Claim
21 words
The method of claim 58 wherein the bioabsorbable polymer is selected from the group consisting of polyphosphate ester and polyhydroxybutyric valerate.
Claim 66
Dependent Claim
14 words
The method of claim 55 wherein the polymer is a co-polymer with the fibrin.
Claim 67
Dependent Claim
17 words
The method of claim 55 wherein the preform of fibrin and polymer also includes a therapeutic substance.
Claim 68
Dependent Claim
13 words
The method of claim 61 wherein the therapeutic substance is incorporated in microcapsules.
Claim 69
Dependent Claim
25 words
The method of claim 61 wherein the therapeutic substance is selected from the group consisting of anticoagulant drugs, antiplatelet drugs, antimetabolite drugs and antimitotic drugs.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-08-31 | 2002-03-02 | 2002-09-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-08-31 | 2006-03-02 | 2006-09-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-08-31 | 2010-03-02 | 2010-09-01 | $7700.00 | Window Closed / Lapsed |