US5246451A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Vascular prosthesis and method
Assignee: Medtronic Inc
•
Filing: 1991-04-30
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Granted: 1993-09-21
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Expires: 2011-04-30
Abstract
Abstract A vascular graft with improved endothelial cell adhesion can be achieved on a fluoropolymer surface of a vascular graft by treating the fluoropolymer with a plasma in the presence of a non-polymerizing gas capable of providing the fluoropolymer with anionic groups and binding a protein to the treated fluoropolymer. In a preferred embodiment, the fluoropolymer surface is a plasma deposited fluoropolymer. Also in a preferred embodiment, autologous endothelial cells are seeded onto the vascular graft prior to implantation of the vascular graft in the human body.
Inventors
- 👤 Paul V. Trescony
- 👤 Patrick Cahalan
- 👤 Kenneth Keeney
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:58
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0076; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L27/507; A61L33/0094; Y; Y10; Y10S; Y10S623/00; Y10S623/92; Y10S623/921
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
60 words
A method for making a vascular prosthesis comprising in sequence the steps of: a. plasma coating a vascular graft material with a fluoropolymer; b. separately treating the deposited fluoropolymer with a plasma in an atmosphere including only non-polymerizing gases and including at least one non-polymerizing gas capable of producing anionic groups; and c. binding a protein to the treated fluoropolymer.
Claim 2
Independent Claim
60 words
A method for making a vascular prosthesis comprising in sequence the steps of: a. plasma coating a vascular graft material with a fluoropolymer; b. separately treating the deposited fluoropolymer with a plasma in an atmosphere including only non-polymerizing gases and including at least one non-polymerizing gas capable of producing anionic groups; and c. binding a protein to the treated fluoropolymer.
Claim 3
Dependent Claim
17 words
The method of claim 1 further comprising the step of seeding endothelial cells onto the bound protein.
Claim 4
Dependent Claim
11 words
The method of claim 1 wherein the non-polymerizing gas is oxygen.
Claim 5
Dependent Claim
27 words
The method of claim 1 wherein the protein is selected from the group consisting of fibronectin, laminin, type I collagen, type III collagen and type IV collagen.
Claim 6
Dependent Claim
18 words
A vascular prosthesis made according to the method of any one of claims 1, 2, 3 or 4.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-09-20 | 1997-03-22 | 1997-09-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-09-20 | 2001-03-22 | 2001-09-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-09-20 | 2005-03-22 | 2005-09-21 | $7700.00 | Window Closed / Lapsed |