US5383928A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stent sheath for local drug delivery
Assignee: Emory University
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Filing: 1993-08-19
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Granted: 1995-01-24
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Expires: 2013-08-19
Abstract
Abstract This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer sheath encompassing at least a portion of the stent and a thickness to allow controlled release of the drug. Also provided is a method of preventing thrombosis and promoting and inhibiting vascular growth in a subject comprising inserting a stent encompassed by the sheath of the invention into a vessel of the subject.
Inventors
- 👤 Neal A. Scott
- 👤 Stephen R. Hanson
- 👤 Spencer B. King, III
- 👤 Laurence A. Harker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:22
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/88; A61F2/02; A61F2/04; A61F2/06; A61F2/07; A61L; A61L31/00; A61L31/04; A61L31/14; A61L31/16; A61F2002/075; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/25; A61L2300/40; A61L2300/42
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
91 words
In combination, a hollow tubular stent having a predetermined length and a separate sheath removably encompassing at least a portion of said hollow tubular stent to locally deliver at least one drug to an area selected from the group consisting of an arterial wall and an arterial lumen into which the stent has been inserted, comprising at least one polymer and at least one drug incorporated within the polymer, the sheath removably encompassing at least a portion of the stent and having a thickness to allow controlled release of the drug.
Claim 2
Dependent Claim
91 words
In combination, a hollow tubular stent having a predetermined length and a separate sheath removably encompassing at least a portion of said hollow tubular stent to locally deliver at least one drug to an area selected from the group consisting of an arterial wall and an arterial lumen into which the stent has been inserted, comprising at least one polymer and at least one drug incorporated within the polymer, the sheath removably encompassing at least a portion of the stent and having a thickness to allow controlled release of the drug.
Claim 3
Dependent Claim
11 words
The sheath of claim 1, wherein the drug is an anticoagulant.
Claim 4
Dependent Claim
12 words
The sheath of claim 2, wherein the anticoagulant is D-Phe-Pro-Arg chloromethyl ketone.
Claim 5
Dependent Claim
39 words
The sheath of claim 2, wherein the anticoagulant is selected from the group consisting of an RGD peptide-containing compound, heparin, antithrombin compounds, platelet receptor antagonists, anti-thrombin antibodies, anti-platelet receptor antibodies, aspirin, protaglandin inhibitors, platelet inhibitors and tick anti-platelet peptide.
Claim 6
Dependent Claim
25 words
A method of preventing thrombosis in a subject comprising inserting a stent encompassed by the sheath of claim 2 into a vessel of the subject.
Claim 7
Dependent Claim
15 words
The sheath of claim 1, wherein the drug is a promoter of vascular cell growth.
Claim 8
Dependent Claim
31 words
The sheath of claim 6, wherein the promoter of vascular cell growth is selected from the group consisting of a growth factor inhibitor, growth factor receptor agonist, transcriptional activator, translational promoter.
Claim 9
Dependent Claim
27 words
A method of promoting vascular cell growth in a subject comprising inserting a stent encompassed by the sheath of claim 6 into a vessel of a subject.
Claim 10
Dependent Claim
15 words
The sheath of claim 1, wherein the drug is an inhibitor of vascular cell growth.
Claim 11
Dependent Claim
63 words
The sheath of claim 9, wherein the inhibitor of vascular cell growth is selected from the group consisting of a growth factor inhibitor, growth factor receptor antagonist, transcriptional repressor, translational repressor, antisense DNA, antisense RNA, replication inhibitor, inhibitory antibodies, antibodies directed against growth factors, bifunctional molecules consisting of a growth factor and a cytotoxin, bifunctional molecules consisting of an antibody and a cytotoxin.
Claim 12
Dependent Claim
27 words
A method of inhibiting vascular cell growth in a subject comprising inserting a stent encompassed by the sheath of claim 9 into a vessel of the subject.
Claim 13
Dependent Claim
29 words
The sheath of claim 1, wherein the drug is selected from the group consisting of a cholesterol-lowering agent, a vasodilating agent, and agents which interfere with endogenous vasoactive mechanisms.
Claim 14
Dependent Claim
10 words
The sheath of claim 1, wherein the polymer is nondegradable.
Claim 15
Dependent Claim
10 words
The sheath of claim 1, wherein the polymer is biodegradable.
Claim 16
Dependent Claim
26 words
The sheath of claim 1, wherein the polymer has a drug release rate of between about 0.001 μg/cm 2 -min and about 100 μg/cm 2 -min.
Claim 17
Dependent Claim
19 words
The sheath of claim 1, wherein the thickness of the polymer is between about 0.01 mm and 10 mm.
Claim 18
Dependent Claim
19 words
The sheath of claim 1, wherein the thickness of the polymer is between about 0.1 mm and 1 mm.
Claim 19
Dependent Claim
16 words
The sheath of claim 1, wherein the sheath is comprised of at least two different drugs.
Claim 20
Dependent Claim
16 words
The sheath of claim 1, wherein the sheath is comprised of at least two different polymers.
Claim 21
Dependent Claim
11 words
The sheath of claim 19, wherein the polymers have different solubilities.
Claim 22
Dependent Claim
12 words
The sheath of claim 19, wherein the polymers have different diffusion characteristics.
Claim 23
Dependent Claim
15 words
The sheath of claim 1, further comprising cultured or autologous cells which line the sheath.
Claim 24
Dependent Claim
13 words
The device of claim 1, wherein the sheath removably encompasses the entire sheath.
Claim 25
Dependent Claim
17 words
The device of claim 1, wherein the sheath removably encompasses only the proximal end of the stent.
Claim 26
Dependent Claim
87 words
A kit comprising a hollow tubular stent and a separate sheath for removably encompassing at least a portion of the stent to locally deliver at least one drug to an area selected from the group consisting of an arterial wall and an arterial lumen into which the stent has been inserted, comprising at least one polymer and at least one drug incorporated within the polymer, the sheath removably encompassing at least a portion of the stent and having a thickness to allow Controlled release of the drug.
Claim 27
Dependent Claim
87 words
A kit comprising a hollow tubular stent and a separate sheath for removably encompassing at least a portion of the stent to locally deliver at least one drug to an area selected from the group consisting of an arterial wall and an arterial lumen into which the stent has been inserted, comprising at least one polymer and at least one drug incorporated within the polymer, the sheath removably encompassing at least a portion of the stent and having a thickness to allow Controlled release of the drug.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-23 | 1998-07-25 | 1999-01-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-23 | 2002-07-25 | 2003-01-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-23 | 2006-07-25 | 2007-01-24 | $7700.00 | Window Closed / Lapsed |