US4687482A
Expired / Lapsed
US
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Vascular prosthesis
Assignee: Scripps Clinic and Research Foundation
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Filing: 1984-04-27
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Granted: 1987-08-18
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Expires: 2004-04-27
Abstract
Abstract A vascular prosthesis for implantation in a living mammalian body and a method for producing same are disclosed. The vascular prosthesis has a hydrophobic polymeric layer on its luminal surface defining a substantially non-thrombogenic flow surface. The polymeric material of the layer defining the flow surface exhibits a rate of platelet consumption of less than about 20×10 8 platelets/cm 2 ·day.
Inventors
- 👤 Stephen R. Hanson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:21
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; A61L27/50; A61L27/507; A61L33/00; A61L33/06; C; C08; C08L; C08L27/00; C08L27/02; C08L27/12; C08L27/18; C08L75/00; C08L75/04; C08L75/08; C08L83/00; C08L83/04; Y; Y10; Y10S; Y10S534/00; Y10S534/02
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
104 words
A vascular prosthesis for implantation in a living mamalian body comprising (a) an elongated tubular segment, said tubular segment having a substantially foraminous, non-complaint, hollow body portion open at both ends, said hollow body portion having a luminal surface defining a confined-flow passageway, and (b) a hydrophobic, physiologically compatible lining constituted by a polymeric material on said luminal surface and defining a thormbus-resistant flow surface that prevents platelet deposition and is free from surface irregularities greater than about 5 microns in height, depth or width, said polymeric material exhibiting a rate of platelet consumption of less than about 20×10 8 platelets/cm 2 . day.
Claim 2
Dependent Claim
104 words
A vascular prosthesis for implantation in a living mamalian body comprising (a) an elongated tubular segment, said tubular segment having a substantially foraminous, non-complaint, hollow body portion open at both ends, said hollow body portion having a luminal surface defining a confined-flow passageway, and (b) a hydrophobic, physiologically compatible lining constituted by a polymeric material on said luminal surface and defining a thormbus-resistant flow surface that prevents platelet deposition and is free from surface irregularities greater than about 5 microns in height, depth or width, said polymeric material exhibiting a rate of platelet consumption of less than about 20×10 8 platelets/cm 2 . day.
Claim 3
Dependent Claim
24 words
The vascular prosthesis of claim 1 wherein said flow surface is thrombus-resistant at an arterial blood flow rate of at least about 50 millimeters/minute.
Claim 4
Dependent Claim
25 words
The vascular prosthesis of claim 1 wherein said polymeric material is made up of a polymer principally constituted by repeating units of a polyether-based polyurethane.
Claim 5
Dependent Claim
27 words
The vascular prosthesis of claim 3 wherein said polyether-based polyurethane is derived from a polytetramethylene ether glycol and a mixture of methylene diisocyanate and a diamine coupler.
Claim 6
Dependent Claim
17 words
The vascular prosthesis of claim 1 wherein said polymeric material is made up of a silicone elastomer.
Claim 7
Dependent Claim
19 words
The vascular prosthesis of claim 15 wherein said silicone elastomer is principally constituted by repeating units of polydimethylsiloxane-methylvinylsiloxane copolymer.
Claim 8
Dependent Claim
20 words
The vascular prosthesis of claim 1 wherein said lining is constituted by a plurality of discrete, substantially coextensive polymeric layers.
Claim 9
Dependent Claim
27 words
The vascular prosthesis of claim 7 wherein the outermost polymeric layer of said lining is made up of a polymer principally constituted by repeating units of tetrafluoroethylene.
Claim 10
Dependent Claim
24 words
The vascular prosthesis of claim 7 wherein the outermost polymeric layer is made up of a polymer principally constituted by repeating units of hexafluoroethane.
Claim 11
Dependent Claim
30 words
The vascular prosthesis of claim 1 wherein said rate of platelet consumption is in a range of about 2.0×10 8 platelets/cm 2 ·day to about 20×10 8 platelets/cm 2 ·day.
Claim 12
Dependent Claim
30 words
The vascular prosthesis of claim 1 wherein said rate of platelet consumption is in a range of about 1.2×10 8 platelets/cm 2 ·day to about 1.8×10 8 platelets/cm 2 ·day.
Claim 13
Dependent Claim
24 words
A vascular prosthesis of claim 1 wherein said lining has a thickness of at least about 100 nanometers and less than about 1.1 millimeters.
Claim 14
Dependent Claim
24 words
The vascular prosthesis of claim 12 wherein said lining has a thickness of at least about 1 micrometer and less than about 1 millimeter
Claim 15
Dependent Claim
24 words
The vascular prosthesis of claim 12 wherein said lining has a thickness of at least about 100 nanometers and less than about 1 micrometer.
Claim 16
Independent Claim
93 words
A method of producing a vascular prothesis having a luminal surface, comprising the steps of: (a) depositing a hydrophobic, physiologically compatible polymeric material exhibiting a rate of platelet consumption of less than about 20×10 8 platelets/cm 2 ·day onto said luminal surface as a layer having a thickness of at least about 100 nanometers to less than about 1.1 millimeters; and, (b) further polymerizing the deposited polymeric material to form a substantially smooth hydrophobic lining on said luminal surface free from surface irregularites greater than about 5 microns in height, depth or width.
Claim 17
Independent Claim
93 words
A method of producing a vascular prothesis having a luminal surface, comprising the steps of: (a) depositing a hydrophobic, physiologically compatible polymeric material exhibiting a rate of platelet consumption of less than about 20×10 8 platelets/cm 2 ·day onto said luminal surface as a layer having a thickness of at least about 100 nanometers to less than about 1.1 millimeters; and, (b) further polymerizing the deposited polymeric material to form a substantially smooth hydrophobic lining on said luminal surface free from surface irregularites greater than about 5 microns in height, depth or width.
Claim 18
Dependent Claim
104 words
The method of claim 15 wherein: (a) said polymeric material is dissolved in a compatible solvent to produce a solution having a polymeric material concentration in the range of about 1 percent by weight to about 20 percent by weight based on the weight of the solvent; (b) said solution is deposited onto said luminal surface; (c) said solvent is removed by evaporation from said deposited solution to form a polymeric residue; and (d) said polymeric residue is cured to form a substantially smooth hydrophobic lining on said luminal surface free from surface irregularities greater than about 5 microns in height, depth or width.
Claim 19
Dependent Claim
14 words
The method of claim 16 wherein said lining is derived from a silicone elastomer.
Claim 20
Dependent Claim
17 words
The method of claim 17 wherein said silicone elastomer is principally constituted by repeating units of polydimethylsiloxane.
Claim 21
Dependent Claim
29 words
The method of claim 16 wherein said solution has a concentration of from about 1 percent to about 20 percent by weight of said polymeric material in said solvent.
Claim 22
Dependent Claim
14 words
The method of claim 16 wherein said solvent is an inert, organic, non-polar solvent.
Claim 23
Dependent Claim
10 words
The method of claim 20 wherein said solvent is hexane.
Claim 24
Dependent Claim
20 words
The method of claim 16 wherein said steps (b)-(d) are repeated successively to form a plurality of discrete polymeric layers.
Claim 25
Dependent Claim
22 words
The method of claim 16 including the further step of depositing a polymeric layer defining a flow surface by glow discharge polymerization.
Claim 26
Dependent Claim
13 words
The method of claim 23 wherein said polymeric layer is derived from tetrafluoroethylene.
Claim 27
Dependent Claim
13 words
The method of claim 23 wherein said polymeric layer is derived from hexafluoroethane.
Claim 28
Dependent Claim
57 words
The method of claim 15 further including the steps of: (a) depositing a preparation containing said polymeric material in a liquid vehicle onto said luminal surface; (b) removing said liquid vehicle by evaporation from said preparation to form a polymeric residue; and, (c) polymerizing further said polymeric residue to form a hydrophobic lining on said luminal surface.
Claim 29
Dependent Claim
28 words
The method of claim 26 wherein said lining is derived from a polymeric material made up of a polymer principally constituted by repeating units of a polyether-based polyurethane.
Claim 30
Dependent Claim
26 words
The method of claim 27 wherein said polyether-based polyurethane is derived from a polytetramethylene ether glycol and a mixture of methylene diisocyanate and a diamine coupler.
Claim 31
Dependent Claim
20 words
The method of claim 26 wherein said steps (a)-(c) are repeated succesively to form a plurality of discrete polymeric layers.
Claim 32
Dependent Claim
22 words
The method of claim 26 including the further step of depositing a polymeric layer defining a flow surface by glow discharge polymerization.
Claim 33
Dependent Claim
13 words
The method of claim 30 wherein said polymeric layer is derived from tetrafluoroethylene.
Claim 34
Dependent Claim
13 words
The method of claim 30 wherein said polymeric layer is derived from hexafluoroethane.
References Cited (Backward Citations)
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