US5849034A
Expired / Lapsed
US
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Intraluminal stent
Assignee: Medtronic Inc
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Filing: 1995-04-27
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Granted: 1998-12-15
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Expires: 2015-04-27
Abstract
Abstract An intraluminal stent comprising fibrin is capable of reducing the incidence of restenosis at the site of vascular injury such as that produced by an angioplasty procedure.
Inventors
- 👤 Robert S. Schwartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:36
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/14; A61L31/16; A61F; A61F2/00; A61F2/82; A61L31/04; A61L31/041; A61L31/043; A61L31/046; A61L31/047; A61L31/08; A61L31/10; A61L31/12; A61L31/125; A61L31/128; A61F2/0077; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/252; A61L2300/40; A61L2300/416; A61L2300/42; A61L2300/60; A61L2300/62; A61L2300/622; Y; Y10; Y10S; Y10S623/00; Y10S623/901
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
51 words
A method for making an intraluminal stent comprising the steps of: (a) providing a stent comprising a plurality of spaced-apart elements; (b) polymerizing fibrin on the stent elements such that the fibrin extends between the spaced-apart stent elements; and (c) radially compressing the stent and polymerized fibrin to a delivery diameter.
Claim 2
Independent Claim
51 words
A method for making an intraluminal stent comprising the steps of: (a) providing a stent comprising a plurality of spaced-apart elements; (b) polymerizing fibrin on the stent elements such that the fibrin extends between the spaced-apart stent elements; and (c) radially compressing the stent and polymerized fibrin to a delivery diameter.
Claim 3
Dependent Claim
28 words
The method of claim 1 wherein the polymerizing step comprises applying to the stent successively (a) a solution of fibrinogen and (b) a solution of a fibrinogen-coagulating protein.
Claim 4
Dependent Claim
14 words
The method of claim 2 of neutralizing the coagulating effect of residual coagulating protein.
Claim 5
Dependent Claim
17 words
The method of claim 3 wherein the protein is neutralized by the addition of a thrombin inhibitor.
Claim 6
Dependent Claim
20 words
The method of claim 2 wherein the fibrinogen-coagulating protein is selected from the group consisting of thrombin, reptilase and ancrod.
Claim 7
Dependent Claim
18 words
The method of claim 1 also comprising the step of incubating the fibrin in a biological buffer solution.
Claim 8
Dependent Claim
22 words
The method of claim 1 also comprising the step of affixing the fibrin stent onto a distal end of a delivery catheter.
Claim 9
Dependent Claim
21 words
The method of claim 7 wherein the delivery catheter has a balloon thereon and the stent is compressed onto the balloon.
Claim 10
Independent Claim
58 words
A method for making an intraluminal stent comprising the steps of: (a) providing a stent comprising a plurality of spaced-apart elements; (b) providing a fibrin preform; (c) applying the fibrin preform to the stent such that the preform extends between the spaced-apart stent elements; and (d) radially compressing the stent and applied fibrin preform to a delivery diameter.
Claim 11
Independent Claim
58 words
A method for making an intraluminal stent comprising the steps of: (a) providing a stent comprising a plurality of spaced-apart elements; (b) providing a fibrin preform; (c) applying the fibrin preform to the stent such that the preform extends between the spaced-apart stent elements; and (d) radially compressing the stent and applied fibrin preform to a delivery diameter.
Claim 12
Dependent Claim
16 words
The method of claim 9 wherein the fibrin preform is a film applied to the stent.
Claim 13
Dependent Claim
17 words
The method of claim 8 wherein the fibrin preform is secured to the stent with an adhesive.
Claim 14
Dependent Claim
21 words
The method of claim 9 also comprising the step of affixing the stent onto a distal end of a delivery catheter.
Claim 15
Dependent Claim
27 words
The method of claim 12 wherein the delivery catheter is a catheter having a balloon and the stent is compressed onto an outside surface of the balloon.
Claim 16
Independent Claim
52 words
A method for making a intravascular device comprising fibrin comprising the steps of: (a) providing an intravascular device; (b) admixing fibrinogen with a coagulating protein to produce fibrin; (c) neutralizing the coagulating protein, (d) incubating the fibrin in a biological buffer solution; and (e) compressing the incubated fibrin onto the intravascular device.
Claim 17
Independent Claim
52 words
A method for making a intravascular device comprising fibrin comprising the steps of: (a) providing an intravascular device; (b) admixing fibrinogen with a coagulating protein to produce fibrin; (c) neutralizing the coagulating protein, (d) incubating the fibrin in a biological buffer solution; and (e) compressing the incubated fibrin onto the intravascular device.
Claim 18
Dependent Claim
24 words
The method of claim 14 wherein the coagulating protein is thrombin and a substance used for neutralizing the coagulating protein is a thrombin inhibitor.
Claim 19
Dependent Claim
22 words
The method of claim 15 wherein the thrombin inhibitor is selected from the group consisting of hirudin and D-phenylalanyl-propyl-arginine chloromethyl ketone (PPACK).
Claim 20
Dependent Claim
18 words
The method of claim 14 wherein the biological buffer solution comprises blood serum buffered with 4-(2-hydroxyethyl)-1-peperazineethanesulfonic acid (HEPES).
Claim 21
Dependent Claim
34 words
The method of claim 1 also comprising the step of compressing the polymerized fibrin of step (b) onto the stent elements such that the fibrin encapsulates the stent elements prior to performing step (c).
Claim 22
Dependent Claim
17 words
The method of claim 9 also comprising the step of compressing the fibrin preform of step (b).
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-12-14 | 2002-06-15 | 2002-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-12-14 | 2006-06-15 | 2006-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-12-14 | 2010-06-15 | 2010-12-15 | $7700.00 | Window Closed / Lapsed |