Patent US5782861A successfully refreshed from Google Patents.
US5865814A
Expired / Lapsed
US
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Blood contacting medical device and method
Assignee: Medtronic Inc
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Filing: 1997-08-06
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Granted: 1999-02-02
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Expires: 2017-08-06
Abstract
Abstract A a blood-contacting medical device with improved biocompatibility. The device is coated with a layer of water-soluble heparin, overlaid by a porous polymeric coating through which the heparin can elute. The inclusion of a porous polymer in intimate contact with a heparin on the device controls the administration of heparin following implantation or other blood contact. The adhesion of the coating and the rate at which the heparin is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer.
Inventors
- 👤 Ronald J. Tuch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:50
CPC Classifications
A; A61; A61L; A61L31/00; A61L31/08; A61L31/10; A61L27/00; A61L27/28; A61L27/34; A61L33/00; A61L33/0005; A61L33/0011; A61F; A61F2/00; A61F2/82; A61F2250/00; A61F2250/0058; A61F2250/0067; A61M; A61M25/00; A61M25/0043; A61M25/0045; Y; Y10; Y10S; Y10S623/00; Y10S623/90
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
63 words
A medical device for use in contact with circulating blood comprising: (a) a medical device having a blood-contacting surface; (b) a first coating layer on the blood-contacting surface consisting essentially of water soluble heparin; and (c) a second coating layer comprising a porous polymer overlaying the first coating layer such that heparin is elutable from the medical device through the second coating layer.
Claim 2
Dependent Claim
63 words
A medical device for use in contact with circulating blood comprising: (a) a medical device having a blood-contacting surface; (b) a first coating layer on the blood-contacting surface consisting essentially of water soluble heparin; and (c) a second coating layer comprising a porous polymer overlaying the first coating layer such that heparin is elutable from the medical device through the second coating layer.
Claim 3
Dependent Claim
14 words
A device according to claim 1 wherein the blood-contacting surface has a metal surface.
Claim 4
Dependent Claim
14 words
A device according to claim 1 wherein the blood-contacting surface has a polymeric surface.
Claim 5
Dependent Claim
13 words
A device according to claim 1 wherein the polymer is a bioabsorbable polymer.
Claim 6
Dependent Claim
21 words
A device according to claim 4 wherein the polymer is selected from the group consisting of poly(lactic acid), poly(lactide-co-glycolide) and poly(hydroxybutyrate-co-valerate).
Claim 7
Dependent Claim
13 words
A device according to claim 1 wherein the polymer is a biostable polymer.
Claim 8
Dependent Claim
30 words
A device according to claim 6 wherein the polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics.
Claim 9
Dependent Claim
15 words
A device according to claim 1 wherein the device is a radially expandable intravascular stent.
Claim 10
Dependent Claim
22 words
A device according to claim 1 in which the porous polymer has average pore diameter in the range of about 0.5-10 microns.
Claim 11
Dependent Claim
74 words
A medical device for use in contact with circulating blood comprising: (a) medical device having a blood-contacting surface; (b) a first coating layer on the blood-contacting surface comprising a hydrophilic polymer; (c) a second coating layer comprising water soluble heparin overlaying the first coating layer; and (d) a third coating layer comprising a porous polymer overlaying the second coating layer such that heparin is elutable from the medical device through the third coating layer.
Claim 12
Dependent Claim
74 words
A medical device for use in contact with circulating blood comprising: (a) medical device having a blood-contacting surface; (b) a first coating layer on the blood-contacting surface comprising a hydrophilic polymer; (c) a second coating layer comprising water soluble heparin overlaying the first coating layer; and (d) a third coating layer comprising a porous polymer overlaying the second coating layer such that heparin is elutable from the medical device through the third coating layer.
Claim 13
Dependent Claim
14 words
A device according to claim 10 wherein the blood-contacting surface has a metal surface.
Claim 14
Dependent Claim
14 words
A device according to claim 10 wherein the blood-contacting surface has a polymeric surface.
Claim 15
Dependent Claim
14 words
A device according to claim 10 wherein the porous polymer is a bioabsorbable polymer.
Claim 16
Dependent Claim
22 words
A device according to claim 13 wherein the bioabsorbable polymer is selected from the group consisting of poly(lactic acid), poly(lactide-co-glycolide) and poly(hydroxybutyrate-co-valerate).
Claim 17
Dependent Claim
14 words
A device according to claim 10 wherein the porous polymer is a biostable polymer.
Claim 18
Dependent Claim
31 words
A device according to claim 15 wherein the biostable polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics.
Claim 19
Dependent Claim
15 words
A device according to claim 10 wherein the device is a radially expandable intravascular stent.
Claim 20
Dependent Claim
74 words
A medical device for use in contact with circulating blood comprising: (a) medical device having a blood-contacting surface; (b) a first coating layer on the blood-contacting surface comprising a hydrophobic polymer; (c) a second coating layer comprising water soluble heparin overlaying the first coating layer; and (d) a third coating layer comprising a porous polymer overlaying the second coating layer such that heparin is elutable from the medical device through the third coating layer.
Claim 21
Dependent Claim
74 words
A medical device for use in contact with circulating blood comprising: (a) medical device having a blood-contacting surface; (b) a first coating layer on the blood-contacting surface comprising a hydrophobic polymer; (c) a second coating layer comprising water soluble heparin overlaying the first coating layer; and (d) a third coating layer comprising a porous polymer overlaying the second coating layer such that heparin is elutable from the medical device through the third coating layer.
Claim 22
Dependent Claim
26 words
A device according to claim 18 wherein the second coating layer comprises beads of heparin, and wherein the third coating layer encapsulates the beads of heparin.
Claim 23
Dependent Claim
14 words
A device according to claim 18 wherein the blood-contacting surface has a metal surface.
Claim 24
Dependent Claim
14 words
A device according to claim 18 wherein the blood-contacting surface has a polymeric surface.
Claim 25
Dependent Claim
14 words
A device according to claim 18 wherein the porous polymer is a bioabsorbable polymer.
Claim 26
Dependent Claim
22 words
A device according to claim 22 wherein the bioabsorbable polymer is selected from the group consisting of poly(lactic acid), poly(lactide-co-glycolide) and poly(hydroxybutyrate-co-valerate).
Claim 27
Dependent Claim
14 words
A device according to claim 18 wherein the porous polymer is a biostable polymer.
Claim 28
Dependent Claim
31 words
A device according to claim 24 wherein the biostable polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics.
Claim 29
Dependent Claim
15 words
A device according to claim 18 wherein the device is a radially expandable intravascular stent.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2002-02-01 | 2002-08-03 | 2003-02-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2006-02-01 | 2006-08-03 | 2007-02-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2010-02-01 | 2010-08-03 | 2011-02-02 | $7700.00 | Window Closed / Lapsed |