US5380299A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thrombolytic treated intravascular medical device
Assignee: Cook Medical Technologies LLC
•
Filing: 1993-08-30
•
Granted: 1995-01-10
•
Expires: 2013-08-30
Abstract
Abstract An intravascular medical device having a structure shaped and sized for introduction into the vascular system of a patient including a base material and a coating of a thrombolytic agent on the base material. The thrombolytic agent advantageously dissolves or breaks up the formation of thrombus on the surface of the structure when placed in the vascular system of a patient. The intravascular medical device also includes a antithrombogenic agent for inhibiting the formation of thrombus on the surface of the medical device. The method of treating a medical device with a thrombolytic agent includes providing a base material for the medical device along with a thrombolytic agent. The base material is dipped into the thrombolytic agent and then removed to allow the thrombolytic agent to dry on the surface thereof. The dipping and drying steps are repeated to increase the concentration or quantity of the thrombolytic agent on the device.
Inventors
- 👤 Neal E. Fearnot
- 👤 Anthony O. Ragheb
- 👤 William D. Voorhees, III
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:26
CPC Classifications
A; A61; A61L; A61L33/00; A61L31/00; A61L31/14; A61L31/16; A61L29/00; A61L29/14; A61L29/16; A61L33/0005; A61L33/0011; A61L33/0047; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/254; A61L2300/40; A61L2300/42
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
52 words
An intravascular medical device comprising: a structure shaped and sized for introduction into a vascular system of a patient, and structure including a base material and a homogeneous coating of a thrombolytic agent and at least one from a group consisting of a cellulose and a cellulose-based polymer on said base material.
Claim 2
Dependent Claim
52 words
An intravascular medical device comprising: a structure shaped and sized for introduction into a vascular system of a patient, and structure including a base material and a homogeneous coating of a thrombolytic agent and at least one from a group consisting of a cellulose and a cellulose-based polymer on said base material.
Claim 3
Dependent Claim
30 words
The medical device of claim 1 wherein said base material comprises at least one from a group consisting of a metal, a carbon, a polymer, and a biologically derived material.
Claim 4
Dependent Claim
26 words
The medical device of claim 2 wherein said thrombolytic agent comprises at least one from a group consisting of urokinase, streptokinase, and a tissue plasminogen activator.
Claim 5
Dependent Claim
15 words
The medical device of claim 1 wherein said homogeneous coating further includes an antithrombogenic agent.
Claim 6
Dependent Claim
24 words
The medical device of claim 4 wherein said antithrombogenic agent comprises at least one from a group consisting of heparin, hirudin, and an antiplatelet.
Claim 7
Dependent Claim
29 words
The medical device of claim 5 wherein said cellulose-based polymer includes at least one from a group consisting of a cellulose acetate, a cellulose ester, and a cellulose nitrate.
Claim 8
Dependent Claim
26 words
The medical device of claim 2 wherein said metal includes at least one from a consisting of stainless steel, tantalum, nitinol, gold, platinum, inconel, and iridium.
Claim 9
Dependent Claim
64 words
An intravascular medical device comprising: a structure shaped and sized for introduction into a vascular system of a patient, said structure including a base material and a homogeneous coating of at least one from a group consisting of a thrombolytic agent and an antithrombogenic agent and at least one from a group consisting of a cellulose and a cellulose-based polymer on said base material.
Claim 10
Dependent Claim
64 words
An intravascular medical device comprising: a structure shaped and sized for introduction into a vascular system of a patient, said structure including a base material and a homogeneous coating of at least one from a group consisting of a thrombolytic agent and an antithrombogenic agent and at least one from a group consisting of a cellulose and a cellulose-based polymer on said base material.
Claim 11
Dependent Claim
27 words
The medical device of claim 8 further including a primer agent for adhering an other of said thrombolytic agent and said antithrombogenic agent to said base material.
Claim 12
Dependent Claim
26 words
The medical device of claim 9 wherein said thrombolytic agent comprises at least one from a group consisting of urokinase, streptokinase, and a tissue plasminogen activator.
Claim 13
Dependent Claim
24 words
The medical device of claim 9 wherein said antithrombogenic agent comprises at least one from a group consisting of heparin, hirudin, and an antiplatelet.
Claim 14
Dependent Claim
37 words
The medical device of claim 9 wherein at least one of said primer agent and said cellulose-based polymer comprises at least one from a group consisting of a cellulose acetate, a cellulose ester and a cellulose nitrate.
Claim 15
Dependent Claim
55 words
An intravascular medical device comprising: a structure shaped and sized for introduction into a vascular system of a patient, said structure including a thrombolytic agent and a base, homogeneous material including said thrombolytic agent and at least one from a group consisting of a cellulose, a cellulose acetate, a cellulose ester, and a cellulose nitrate.
Claim 16
Dependent Claim
55 words
An intravascular medical device comprising: a structure shaped and sized for introduction into a vascular system of a patient, said structure including a thrombolytic agent and a base, homogeneous material including said thrombolytic agent and at least one from a group consisting of a cellulose, a cellulose acetate, a cellulose ester, and a cellulose nitrate.
Claim 17
Dependent Claim
13 words
The medical device of claim 13 wherein said structure includes an antithrombogenic agent.
Claim 18
Dependent Claim
20 words
The medical device of claim 14 wherein said structure includes a primer for adhering said antithrombogenic to said base material.
Claim 19
Dependent Claim
30 words
The medical device of claim 15 wherein said primer includes at least one of a group consisting of a cellulose, a cellulose acetate, a cellulose ester and a cellulose nitrate.
Claim 20
Dependent Claim
24 words
The medical device of claim 14 wherein said antithrombogenic agent comprises at least one from a group consisting of heparin, hirudin, and an antiplatelet.
Claim 21
Dependent Claim
26 words
The medical device of claim 13 wherein said thrombolytic agent comprises at least one from a group consisting of urokinase, streptokinase, and a tissue plasminogen activator.
References Cited (Backward Citations)
US4305926A
Cited
US4502159A
Cited
US4879135A
Cited
US4917686A
Cited
US4909799A
Cited
US5098977A
Cited
US5019601A
Cited
US5019096A
Cited
US4950256A
Cited
US4994047A
Cited
US5182317A
Cited
US5019393A
Cited
US5165952A
Cited
US5004461A
Cited
US5135516A
Cited
US5163952A
Cited
US5222971A
Cited
US5229172A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-01-09 | 1998-07-11 | 1999-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-01-09 | 2002-07-11 | 2003-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-01-09 | 2006-07-11 | 2007-01-10 | $7700.00 | Window Closed / Lapsed |