US4305926A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immobilization of Streptokinase
Assignee: EVERSE KATHLEEN E
•
Filing: 1979-09-13
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Granted: 1981-12-15
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Expires: 1999-09-13
Abstract
Abstract The invention comprises the construction of an implantable device consisting of a clot lysing inhibitor immobilized onto a biocompatible polymer, and the method of regulation of blood clotting time, the prevention of blood clot formation, and the hydrolysis of existing blood clots with the use of said device. A method is also disclosed to prevent the growth of fibrous connective tissue on prosthetic devices.
Inventors
- 👤 Johannes Everse
- 👤 Kathleen E. Everse
- 👤 Leo C. Mercer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:55
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0047
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
43 words
The process of control of blood clotting in a living mammal comprising: providing a clot-lysing initiator immobilized on a solid water insoluble non-colloidal substrate; and implanting said initiator supporting substrate in the body of said living mammal in contact with its body fluid.
Claim 2
Dependent Claim
43 words
The process of control of blood clotting in a living mammal comprising: providing a clot-lysing initiator immobilized on a solid water insoluble non-colloidal substrate; and implanting said initiator supporting substrate in the body of said living mammal in contact with its body fluid.
Claim 3
Dependent Claim
19 words
The process recited in claim 1 wherein said initiator is selected from the group consisting of streptokinase and urokinase.
Claim 4
Dependent Claim
26 words
The process recited in claim 1 wherein said carrier substrate has a form selected from the group consisting of tubular material, fiber material and woven cloth.
Claim 5
Dependent Claim
26 words
The process recited in claim 1 wherein said carrier substrate is selected from the group consisting of nylon, copolymeric p-aminophenylalanine and leucine, dacron, collagen and polyvinylpyrolidone.
Claim 6
Dependent Claim
16 words
The process recited in claim 1 wherein said carrier substrate is subcutaneously implanted in an animal.
Claim 7
Dependent Claim
27 words
The process recited in claim 4 wherein said animal is a human and said body fluid is selected from the group consisting of blood and interstitial fluid.
Claim 8
Dependent Claim
54 words
A blood clotting control device comprising: a body fluid contacting means comprising, a solid water insoluble non-colloidal carrier substrate and immobilized clot lysing initiator carried by said solid carrier substrate, said solid carrier substrate and clot lysing initiator being adapted to be implanted in a living mammal in contact with the body fluids thereof.
Claim 9
Dependent Claim
54 words
A blood clotting control device comprising: a body fluid contacting means comprising, a solid water insoluble non-colloidal carrier substrate and immobilized clot lysing initiator carried by said solid carrier substrate, said solid carrier substrate and clot lysing initiator being adapted to be implanted in a living mammal in contact with the body fluids thereof.
Claim 10
Dependent Claim
21 words
The device recited in claim 7 wherein said immobilized clot-lysing initiator is selected from the group consisting of streptokinase and urokinase.
Claim 11
Dependent Claim
46 words
The device recited in claim 7 wherein said substrate consisting of a material selected from the group consisting of nylon, copolymeric p-aminophenylalanine and leucine, dacron, collagen and polyvinylpyrolidone; and said substrate further consisting of a form selected from the group comprising fiber, tube and woven cloth.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-14 | 1985-06-15 | 1985-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-14 | 1989-06-15 | 1989-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-14 | 1993-06-15 | 1993-12-15 | $7700.00 | Window Closed / Lapsed |