US3875008A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hollow filament containing enzymes and/or microorganisms
Assignee: Asahi Kasei Corp
•
Filing: 1973-07-31
•
Granted: 1975-04-01
•
Expires: 1993-07-31
Abstract
Abstract Enzymes and/or microorganisms are encapsulated in a hollow filament by a process involving extruding a solution of polymer through an annular orifice into a coagulation bath while at the same time injecting a solution or suspension of an enzyme and/or a microorganism through the internal portion of the orifice into the hollow space of the filament being formed by the annular orifice. The wall of the resultant filament is a semi-permeable gel and the filament is highly active for reaction of substrates with the enzyme and/or microorganism.
Inventors
- 👤 Masatsugu Yoshino
- 👤 Yasuo Hashino
- 👤 Masataka Morishita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:18
CPC Classifications
B; B01; B01J; B01J13/00; B01J13/02; B01J13/04; B01J13/046; C; C12; C12N; C12N11/00; C12N11/02; C12N11/04
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
103 words
A HOLLOW FILAMENT ENCAPSULATING THEREIN A SOLUTION OR DISPERSION OF AN ENZYME, A MICROORGANISM OR BOTH, SAID HOLLOW FILAMENT COMPRISING WALL MATERIAL OF A SEMIPERMEABLE GEL OF A POLYMER SELECTED FROM THE GROUP CONISISTING OF POLYACRYLONITRILE, POLYMETHACRYLONITRILE, CELLULOSE ACETATE, CELLULOSE ACEHYTATE PHTHALATE, HYDROXYPROPYL METHYL CELLULOSE PHTHALATE, HYDROXYPROPYL METHYL CELLULOSE TRIMELLITATE, VINYL CHLORIDEVINYL ACETATE COPOLYMER, POLYURETHANE, POLYSULFONE AND COPOLYMERS CONTAINING THESE POLYMER COMPONENTS, SAID WALL MATERIAL HAVING A WATER PERMEABILITY OF AT LEAST 0.1 ML/CM2.MIN.ATM., AND SAID FILAMENT HAVING AN EXTERNAL DIAMETER OF FROM ABOUT 0.1 MM TO ABOUT 1.5 MM AND AN INSIDE DIAMETER OF FROM ABOUT 0.06 MM TO ABOUT 1.3 MM.
Claim 2
Dependent Claim
103 words
A HOLLOW FILAMENT ENCAPSULATING THEREIN A SOLUTION OR DISPERSION OF AN ENZYME, A MICROORGANISM OR BOTH, SAID HOLLOW FILAMENT COMPRISING WALL MATERIAL OF A SEMIPERMEABLE GEL OF A POLYMER SELECTED FROM THE GROUP CONISISTING OF POLYACRYLONITRILE, POLYMETHACRYLONITRILE, CELLULOSE ACETATE, CELLULOSE ACEHYTATE PHTHALATE, HYDROXYPROPYL METHYL CELLULOSE PHTHALATE, HYDROXYPROPYL METHYL CELLULOSE TRIMELLITATE, VINYL CHLORIDEVINYL ACETATE COPOLYMER, POLYURETHANE, POLYSULFONE AND COPOLYMERS CONTAINING THESE POLYMER COMPONENTS, SAID WALL MATERIAL HAVING A WATER PERMEABILITY OF AT LEAST 0.1 ML/CM2.MIN.ATM., AND SAID FILAMENT HAVING AN EXTERNAL DIAMETER OF FROM ABOUT 0.1 MM TO ABOUT 1.5 MM AND AN INSIDE DIAMETER OF FROM ABOUT 0.06 MM TO ABOUT 1.3 MM.
Claim 3
Dependent Claim
70 words
A process for producing a hollow filament as defined in claim 1, which comprises extruding a solution of the polymer forming the semi-permeable gel into a coagulation bath through a nozzle having an annular orifice and, at the same time, injecting as an internal coagulant a solution or dispersion of enzyme, microorganism or both through the internal portion of said orifice and coaguating the resulting hollow filament in said bath.
Claim 4
Dependent Claim
22 words
The process according to claim 2 wherein a buffer liquid is used as medium for the coagulation bath and the internal coagulant.
Claim 5
Dependent Claim
37 words
The process according to claim 2 wherein a solvent, selected from the group consisting of dimethyl sulfoxide, N,N-dimethyl formamide, N,N-dimethyl acetamide, formamide, acetone and a concentrated aqueous solution of Rhodan salts, is used as a polymer solvent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-03-31 | 1978-09-30 | 1979-04-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-03-31 | 1982-09-30 | 1983-04-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-03-31 | 1986-09-30 | 1987-04-01 | $7700.00 | Window Closed / Lapsed |