US3980772A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of dissolving blood clots and the like with streptokinase chemically bonded to a carbohydrate matrix
Assignee: Baxter International Inc
•
Filing: 1971-09-30
•
Granted: 1976-09-14
•
Expires: 1991-09-30
Abstract
Abstract One part by weight of streptokinase is chemically bonded to one to five hundred parts by weight of a carbohydrate, to form a material which has improved stability compared with free streptokinase.
Inventors
- 👤 Leonard George Ginger
- 👤 Adaline Nicoles Mather
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 04:33
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/164; A61K38/166; C; C12; C12N; C12N11/00; C12N11/02; C12N11/10
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
72 words
The process of dissolving blood clots and the like present in a living subject which comprises bringing into contact with said clot a composition of matter which comprises one part by weight of streptokinase chemically bonded to from ten to 200 parts by weight of a water soluble dextran support medium, said composition of matter being in the form of a colloidal solution having a particle size of less than 2 microns.
Claim 2
Dependent Claim
72 words
The process of dissolving blood clots and the like present in a living subject which comprises bringing into contact with said clot a composition of matter which comprises one part by weight of streptokinase chemically bonded to from ten to 200 parts by weight of a water soluble dextran support medium, said composition of matter being in the form of a colloidal solution having a particle size of less than 2 microns.
Claim 3
Dependent Claim
18 words
The process of claim 1 in which said composition of matter is directly injected to said living subject.
Claim 4
Dependent Claim
56 words
The process of claim 2 in which said composition of matter is prepared by contacting a carbohydrate with cyanogen bromide under alkaline conditions to form a reaction product therebetween, and thereafter contacting one part by weight of streptokinase with from 10 to 200 parts by weight of said reaction product to form a chemically bonded adduct.
Claim 5
Dependent Claim
36 words
The process of claim 3 in which said alkaline conditions used for preparing said reaction product constitute an aqueous medium having a pH of at least 11 in which said dextran and cyanogen bromide are placed.
Claim 6
Dependent Claim
19 words
The process of claim 3 in which said dextran has a molecular weight of about 70,000 to about 500,000.
Claim 7
Dependent Claim
16 words
The process of claim 5 in which said dextran has a molecular weight of about 70,000.
References Cited (Backward Citations)
US3226304A
Cited
DE1815332A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-14 | 1980-03-15 | 1980-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-14 | 1984-03-15 | 1984-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-14 | 1988-03-15 | 1988-09-14 | $7700.00 | Window Closed / Lapsed |