Patent US4305926A successfully refreshed from Google Patents.
US4305926A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immobilization of Streptokinase
Assignee: EVERSE KATHLEEN E
•
Filing: 1979-09-13
•
Granted: 1981-12-15
•
Expires: 1999-09-13
Abstract
Abstract The invention comprises the construction of an implantable device consisting of a clot lysing inhibitor immobilized onto a biocompatible polymer, and the method of regulation of blood clotting time, the prevention of blood clot formation, and the hydrolysis of existing blood clots with the use of said device. A method is also disclosed to prevent the growth of fibrous connective tissue on prosthetic devices.
Inventors
- 👤 Johannes Everse
- 👤 Kathleen E. Everse
- 👤 Leo C. Mercer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:31
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/02; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0047
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
43 words
The process of control of blood clotting in a living mammal comprising: providing a clot-lysing initiator immobilized on a solid water insoluble non-colloidal substrate; and implanting said initiator supporting substrate in the body of said living mammal in contact with its body fluid.
Claim 2
Dependent Claim
43 words
The process of control of blood clotting in a living mammal comprising: providing a clot-lysing initiator immobilized on a solid water insoluble non-colloidal substrate; and implanting said initiator supporting substrate in the body of said living mammal in contact with its body fluid.
Claim 3
Dependent Claim
19 words
The process recited in claim 1 wherein said initiator is selected from the group consisting of streptokinase and urokinase.
Claim 4
Dependent Claim
26 words
The process recited in claim 1 wherein said carrier substrate has a form selected from the group consisting of tubular material, fiber material and woven cloth.
Claim 5
Dependent Claim
26 words
The process recited in claim 1 wherein said carrier substrate is selected from the group consisting of nylon, copolymeric p-aminophenylalanine and leucine, dacron, collagen and polyvinylpyrolidone.
Claim 6
Dependent Claim
16 words
The process recited in claim 1 wherein said carrier substrate is subcutaneously implanted in an animal.
Claim 7
Dependent Claim
27 words
The process recited in claim 4 wherein said animal is a human and said body fluid is selected from the group consisting of blood and interstitial fluid.
Claim 8
Dependent Claim
54 words
A blood clotting control device comprising: a body fluid contacting means comprising, a solid water insoluble non-colloidal carrier substrate and immobilized clot lysing initiator carried by said solid carrier substrate, said solid carrier substrate and clot lysing initiator being adapted to be implanted in a living mammal in contact with the body fluids thereof.
Claim 9
Dependent Claim
54 words
A blood clotting control device comprising: a body fluid contacting means comprising, a solid water insoluble non-colloidal carrier substrate and immobilized clot lysing initiator carried by said solid carrier substrate, said solid carrier substrate and clot lysing initiator being adapted to be implanted in a living mammal in contact with the body fluids thereof.
Claim 10
Dependent Claim
21 words
The device recited in claim 7 wherein said immobilized clot-lysing initiator is selected from the group consisting of streptokinase and urokinase.
Claim 11
Dependent Claim
46 words
The device recited in claim 7 wherein said substrate consisting of a material selected from the group consisting of nylon, copolymeric p-aminophenylalanine and leucine, dacron, collagen and polyvinylpyrolidone; and said substrate further consisting of a form selected from the group comprising fiber, tube and woven cloth.
References Cited (Backward Citations)
US4004979A
Cited
US3522346A
Cited
US3715277A
Cited
US4061141A
Cited
US3980772A
Cited
US3639213A
Cited
US3730841A
Cited
US4029767A
Cited
US4178368A
Cited
US3826678A
Cited
US3875008A
Cited
US3865726A
Cited
US3809605A
Cited
US3985616A
Cited
US4004980A
Cited
US4169014A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-14 | 1985-06-15 | 1985-12-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-14 | 1989-06-15 | 1989-12-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-14 | 1993-06-15 | 1993-12-15 | $7700.00 | Window Closed / Lapsed |