US5165952A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-infective and antithrombogenic medical articles and method for their preparation
Assignee: Becton Dickinson and Co
•
Filing: 1990-09-21
•
Granted: 1992-11-24
•
Expires: 2010-09-21
Abstract
Abstract An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithrombogenic agent or a polymeric surface layer laminated onto the base layer. The invention includes a method for preparing the article wherein a homogeneous melt of polymer and chlorhexidine is prepared by twin screw compounding and the melt is extruded to give a medical article having bulk distributed chlorhexidine.
Inventors
- 👤 Donald D. Solomon
- 👤 M. Parke Byron
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 17:35
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/04; A61L29/06; A61L29/08; A61L29/085; A61L29/14; A61L29/16; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/20; A61L2300/204; A61L2300/206; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/45; A61M; A61M25/00; A61M25/0043; A61M2025/0056
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
91 words
A method for preparing a medical article, the method comprising: a) preparing a blend of chlorhexidine and pellets of a base polymer having a water absorption of at least 0.6% by weight; b) heating said blend to a sufficient temperature within a range from about 160° C. to about 250° C. and for a sufficient time to form a homogeneous melt of said polymer having said chlorhexidine uniformly distributed therein; and c) extruding said melt through a die to form a medical article having said chlorhexidine bulk distributed throughout said polymer.
Claim 2
Independent Claim
91 words
A method for preparing a medical article, the method comprising: a) preparing a blend of chlorhexidine and pellets of a base polymer having a water absorption of at least 0.6% by weight; b) heating said blend to a sufficient temperature within a range from about 160° C. to about 250° C. and for a sufficient time to form a homogeneous melt of said polymer having said chlorhexidine uniformly distributed therein; and c) extruding said melt through a die to form a medical article having said chlorhexidine bulk distributed throughout said polymer.
Claim 3
Dependent Claim
24 words
The method in accordance with claim 1 wherein said based polymer is selected from the group consisting of polyurethane, polyurethaneurea and siloxane-urethane block copolymer.
Claim 4
Dependent Claim
20 words
The method in accordance with claim 1 wherein said chlorhexidine is about 0.1 to 10% by weight of said polymer.
Claim 5
Dependent Claim
34 words
The method in accordance with claim 1 wherein said melt is formed by twin screw compounding and wherein said heating step is at said temperature range from about 200° C. to about 235° C.
Claim 6
Dependent Claim
19 words
The method in accordance with claim 1 further comprising wetting said pellets with a polyol prior to said preparing.
Claim 7
Dependent Claim
23 words
The method in accordance with claim 1 wherein said chlorhexidine is selected from the group consisting of chlorhexidine base and a salt thereof.
Claim 8
Dependent Claim
24 words
The method in accordance with claim 6 wherein said salt of chlorhexidine is selected from the group consisting of the hydrochloride, acetate and gluconate.
Claim 9
Dependent Claim
34 words
The method of claim 1 further comprising applying to a surface of said article a coating of an agent selected from the group consisting of chlorhexidine, a surface active agent and an antithrombogenic agent.
Claim 10
Dependent Claim
23 words
The method in accordance with claim 8 wherein said applying step is performed by steeping said article in a solution of said agent.
Claim 11
Dependent Claim
30 words
The method in accordance with claim 8 further comprising ionically bonding an agent selected from the group consisting of an antibiotic and an antithrombogenic agent to said surface active agent.
Claim 12
Dependent Claim
40 words
The method of claim 1 further comprising coating the article having bulk distributed chlorhexidine with a layer of laminating polymer having a water absorption of at least 0.6% by weight and chlorhexidine bulk distributed therein to give a coated article.
Claim 13
Dependent Claim
24 words
The method of claim 11 wherein said coating step is performed by steeping the article in a solution of said laminating polymer and chlorhexidine.
Claim 14
Dependent Claim
39 words
The method of claim 11 further comprising applying a surface active agent to the surface of said article and reacting the surface active agent with a reagent selected from the group consisting of an antibiotic and an antithrombogenic agent.
Claim 15
Independent Claim
66 words
A method for preparing a medical article, the method comprising: a) preparing a homogeneous melt of a polymer having a water absorption of at least 0.6% by weight and a chlorhexidine; and b) extruding said melt at a temperature in a range from about 160° C. to about 250° C. through a die to form a medical article having said chlorhexidine bulk distributed throughout said polymer.
Claim 16
Independent Claim
66 words
A method for preparing a medical article, the method comprising: a) preparing a homogeneous melt of a polymer having a water absorption of at least 0.6% by weight and a chlorhexidine; and b) extruding said melt at a temperature in a range from about 160° C. to about 250° C. through a die to form a medical article having said chlorhexidine bulk distributed throughout said polymer.
References Cited (Backward Citations)
US3604426A
Cited
US4557724A
Cited
US4539234A
Cited
US4675347A
Cited
US4678660A
Cited
US4642267A
Cited
US4729914A
Cited
US5019096A
Cited
US4925668A
Cited
US4999210A
Cited
US5013306A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-11-24 | 1996-05-25 | 1996-11-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-11-24 | 2000-05-25 | 2000-11-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-11-24 | 2004-05-25 | 2004-11-24 | $7700.00 | Window Closed / Lapsed |