US4879135A
Expired / Lapsed
US
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Drug bonded prosthesis and process for producing same
Assignee: NEW JERSEY ADMINISTRATION COMPLEX, University of, Medicine and Dentistry of
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Filing: 1988-07-18
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Granted: 1989-11-07
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Expires: 2008-07-18
Abstract
Abstract There is disclosed an improved prosthesis coated, respectively, with an anionic surfactant, a drug such as an antibiotic and/or antithrombotic agent. Optionally, the coated prosthesis may be treated with an ion exchange compound, to remove un-drug bound anionic surfactant. The drug is bound directly to the surfactant coated prosthesis.
Inventors
- 👤 Ralph S. Greco
- 👤 Richard A. Harvey
- 👤 Stanley Z. Trooskin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:27
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61L2300/00; A61L2300/20; A61L2300/252; A61L2300/254; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/42; A61L2300/60; A61L2300/606; A61L2300/80; A61L2300/802
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
25 words
A prosthesis for use in in vivo surgery having a coating, respectively, of an anionic surfactant and an oppositely charged drug bound to the surfactant.
Claim 2
Dependent Claim
25 words
A prosthesis for use in in vivo surgery having a coating, respectively, of an anionic surfactant and an oppositely charged drug bound to the surfactant.
Claim 3
Dependent Claim
24 words
The prosthesis as defined in claim 1 wherein said drug is selected from the group consisting of clindamycin, tobramycin, aminoglycoside, gentamycin, kanamycin and streptomycin.
Claim 4
Dependent Claim
14 words
The prosthesis as defined in claim 1 wherein said drug is an antithrombotic drug.
Claim 5
Dependent Claim
14 words
The prosthesis as defined in claim 1 wherein said drug is a thrombolytic enzyme.
Claim 6
Dependent Claim
15 words
The prosthesis as defined in claim 4 wherein said thrombolytic enzyme is tissue plasminogen activator.
Claim 7
Dependent Claim
13 words
The prosthesis as defined in claim 1 wherein said surfactant is a dioctadecylphosphate.
Claim 8
Dependent Claim
14 words
The prosthesis as defined in claim 1 wherein said prosthesis is a vascular graft.
Claim 9
Independent Claim
64 words
A method for preparing a prosthesis for use in in vivo surgery, which comprises: (a) contacting said prosthesis with an anionic surfactant to coat said prosthesis with said surfactant; (b) contacting said prosthesis of step (a) with a solution of an oppositely charged drug; and optionally (c) contacting said prosthesis of step (b) with an appropriate ion exchange compound to remove un-drug bound surfactant.
Claim 10
Independent Claim
64 words
A method for preparing a prosthesis for use in in vivo surgery, which comprises: (a) contacting said prosthesis with an anionic surfactant to coat said prosthesis with said surfactant; (b) contacting said prosthesis of step (a) with a solution of an oppositely charged drug; and optionally (c) contacting said prosthesis of step (b) with an appropriate ion exchange compound to remove un-drug bound surfactant.
Claim 11
Dependent Claim
23 words
The method as defined in claim 8 wherein the prosthesis of step (a) is washed to remove excess surfactant prior to step (b).
Claim 12
Dependent Claim
24 words
The method as defined in claim 8 wherein said prosthesis of step (b) is washed to remove unbound drug compound prior to step (c).
Claim 13
Dependent Claim
24 words
The method as defined in claim 9 wherein said prosthesis of step (b) is washed to remove unbound drug compound prior to step (c).
Claim 14
Dependent Claim
13 words
The method as defined in claim 8 wherein said surfactant is a dioctadecylphosphate.
Claim 15
Dependent Claim
24 words
The method as defined in claim 8 wherein said drug is selected from the group consisting of clindamycin, tobramycin, aminoglycoside, gentamycin, kanamycin and streptomycin.
Claim 16
Dependent Claim
14 words
The method as defined in claim 8 wherein said drug is an antithrombotic drug.
Claim 17
Dependent Claim
14 words
The method as defined in claim 8 wherein said drug is a thrombolytic enzyme.
Claim 18
Dependent Claim
15 words
The method as defined in claim 15 wherein said thrombolytic enzyme is tissue plasminogen activator.
Claim 19
Dependent Claim
21 words
The method as defined in claim 8 wherein said ion exchange compound is selected from the group consisting of DEAE-Sepharose--and DEAE-cellulose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-11-06 | 1993-05-08 | 1993-11-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-11-06 | 1997-05-08 | 1997-11-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-11-06 | 2001-05-08 | 2001-11-07 | $7700.00 | Window Closed / Lapsed |