US4612337A
Expired / Lapsed
US
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Method for preparing infection-resistant materials
Assignee: TURSTEES OF COLUMBIA UNIVERSITY IN CITY OF NEW YORK
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Filing: 1985-05-30
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Granted: 1986-09-16
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Expires: 2005-05-30
Abstract
Abstract An infection-resistant polymeric material, such as polytetrafluoroethylene, for use on or within a human or animal body, for example, in the form of a vascular graft, can be prepared by an improved method which comprises the following sequence of steps: (a) soaking a polymeric material with a solution of an antimicrobial agent, such as sodium sulfadiazine, oxacillin dissolved in an organic solvent therefor, such as an ethanol/chloroform mixture, (b) soaking the polymeric material with an organic solvent, such as ethanol, for a metal salt; and (c) resoaking the polymeric material with the solution of the antimicrobial agent dissolved in the organic solvent therefor. The polymeric material is dried after each soaking step. Preferably, in the intermediate soaking step (b) the organic solvent contains a metal salt, such as silver nitrate, dissolved therein, so as to form in situ the metal salt of the antimicrobial agent, such as silver sulfadiazine.
Inventors
- 👤 Charles L. Fox, Jr.
- 👤 Shanta M. Modak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 14:21
CPC Classifications
A; A61; A61L; A61L29/00; A61L29/14; A61L29/16; A61L27/00; A61L27/50; A61L27/54; A61P; A61P31/00; A61P31/04; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/45
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
84 words
A method of preparing an infection-resistant polymeric material for use on or within a human or animal body which comprises the following sequence of steps: (a) soaking a polymeric material with a solution of an antimicrobial agent dissolved in an organic solvent therefor, (b) soaking the polymeric material with an organic solvent for a metal salt, (c) resoaking the polymeric material with the solution of the antimicrobial agent dissolved in the organic solvent therefor, and (d) drying the polymeric material after each soaking step.
Claim 2
Independent Claim
84 words
A method of preparing an infection-resistant polymeric material for use on or within a human or animal body which comprises the following sequence of steps: (a) soaking a polymeric material with a solution of an antimicrobial agent dissolved in an organic solvent therefor, (b) soaking the polymeric material with an organic solvent for a metal salt, (c) resoaking the polymeric material with the solution of the antimicrobial agent dissolved in the organic solvent therefor, and (d) drying the polymeric material after each soaking step.
Claim 3
Dependent Claim
19 words
A method according to claim 1 wherein in step (b) said organic solvent contains a metal salt dissolved therein.
Claim 4
Dependent Claim
24 words
A method according to claim 2 wherein the metal of the metal salt is selected from the group consisting of silver, zinc and cerium.
Claim 5
Dependent Claim
11 words
A method according to claim 3 wherein said metal is silver.
Claim 6
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said antimicrobial agent is norfloxacin.
Claim 7
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said antimicrobial agent is oxacillin.
Claim 8
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said antimicrobial agent is nafcillin.
Claim 9
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said antimicrobial agent is sulfadiazine.
Claim 10
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said antimicrobial agent is pefloxacin.
Claim 11
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said antimicrobial agent is tobramycin.
Claim 12
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said polymeric material is polytetrafluoroethylene.
Claim 13
Dependent Claim
15 words
A method according to claim 1 or 4 wherein said polymeric material is a polyester.
Claim 14
Dependent Claim
16 words
A method according to claim 1 or 4 wherein said polymeric material is a silicone elastomer.
Claim 15
Dependent Claim
14 words
A method according to claim 1 or 4 wherein said polymeric material is silk.
Claim 16
Dependent Claim
42 words
A method according to claim 1 or 4 wherein the polymeric material is a polyester and the polymeric material is resoaked with the solution of the antimicrobial agent dissolved in the organic solvent therefor which contains a small amount of polylactic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-15 | 1990-03-17 | 1990-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-15 | 1994-03-17 | 1994-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-15 | 1998-03-17 | 1998-09-16 | $7700.00 | Window Closed / Lapsed |