US5229172A
Expired / Lapsed
US
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Modification of polymeric surface by graft polymerization
Assignee: Medtronic Inc
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Filing: 1993-01-19
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Granted: 1993-07-20
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Expires: 2013-01-19
Abstract
Abstract A method for modifying the surface characteristics of a polymeric material by irradiating a surface of the polymeric material in the presence of an oxygen and then grafting acrylamide to the irradiated surface by contacting the irradiated surface with an aqueous solution including acrylamide monomer and ceric ion. Grafted polymer surfaces with dense surface coverage are produced without using a deaerated monomer solution. Biofunctional molecules can be ionically or covalently bonded to the grafted surface.
Inventors
- 👤 Patrick T. Cahalan
- 👤 Michel Verhoeven
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:04
CPC Classifications
C; C08; C08J; C08J7/00; C08J7/12; C08J7/16; C08J7/18; A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0029; A61L33/0076; A61L33/0088
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
66 words
A method for modifying the surface characteristics of a solid polymeric material comprising the steps of; (a) irradiating a surface of the polymeric material in the presence of an oxygen source such that the bulk properties of the material are not degraded; (b) applying to the irradiated surface an aqueous solution including acrylamide monomer and ceric ion, whereby the monomer is grafted to the irradiated surface.
Claim 2
Independent Claim
66 words
A method for modifying the surface characteristics of a solid polymeric material comprising the steps of; (a) irradiating a surface of the polymeric material in the presence of an oxygen source such that the bulk properties of the material are not degraded; (b) applying to the irradiated surface an aqueous solution including acrylamide monomer and ceric ion, whereby the monomer is grafted to the irradiated surface.
Claim 3
Dependent Claim
29 words
A method according to claim 1 wherein the polymeric material is selected from the group consisting of polyurethanes, silicones, polyolefins, fluoropolymers, polyesters, polyethers, polyamides and blends and copolymers thereof.
Claim 4
Dependent Claim
31 words
A method according to claim 1 wherein the irradiating step is accomplished by an irradiation method selected from the group consisting of plasma discharge, corona discharge, electron beam, and gamma radiation.
Claim 5
Independent Claim
74 words
A method for modifying the surface characteristics of a solid polymeric material comprising the steps of; (a) irradiating a surface of the polymeric material in the presence of an oxygen source by an irradiation method selected from the group consisting of plasma discharge, corona discharge, electron beam, and gamma radiation; (b) applying to the irradiated surface an aqueous solution including acrylamide monomer and ceric ion, whereby the monomer is grafted to the irradiated surface.
Claim 6
Independent Claim
74 words
A method for modifying the surface characteristics of a solid polymeric material comprising the steps of; (a) irradiating a surface of the polymeric material in the presence of an oxygen source by an irradiation method selected from the group consisting of plasma discharge, corona discharge, electron beam, and gamma radiation; (b) applying to the irradiated surface an aqueous solution including acrylamide monomer and ceric ion, whereby the monomer is grafted to the irradiated surface.
Claim 7
Dependent Claim
25 words
A method according to claim 4 wherein the polymeric material is selected from the group consisting of polyurethanes, silicones, polyolefins, fluoropolymers, polyesters, polyethers, and polyamides.
Claim 8
Dependent Claim
31 words
A method according to claim 4 wherein the irradiation applied is corona discharge radiation applied to the polymeric material at an intensity in the range of about 0.2 to 1.0 kilowatts.
Claim 9
Dependent Claim
32 words
A method according to claim 4 wherein the irradiation applied is a radio frequency plasma applied to the polymeric material at an intensity in the range of about 15 to 25 watts.
Claim 10
Dependent Claim
31 words
A method according to claim 4 wherein the irradiation applied is an electron beam applied to the polymeric material at an intensity in the range of about 1 to 3 Kgray.
Claim 11
Dependent Claim
31 words
A method according to claim 1 or 4 wherein the acrylamide monomer is at a concentration in the aqueous solution in the range of about 20 to 40 percent by weight.
Claim 12
Dependent Claim
33 words
A method according to claim 9 wherein the ceric ion in the solution is at a concentration in the range of about 0.0002 to 0.0005 mole of ceric ion per mole of monomer.
Claim 13
Dependent Claim
20 words
A method according to claim 1 or 4 further comprising the step of attaching a biomolecule to the grafted surface.
Claim 14
Dependent Claim
25 words
A method according to claim 11 wherein the biomolecule is selected from the group consisting of albumin, fibrinogen fibronectin, heparin, glycoproteins, immunoglobulins, and growth factors.
Claim 15
Dependent Claim
26 words
A method according to claim 11 further comprising the step of applying between the grafted surface and biomolecule a coupling agent which is at least bifunctional.
Claim 16
Dependent Claim
20 words
A method according to claim 13 wherein the coupling agent is selected from the group consisting of ethylenediamine and polyethyleneimine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1996-07-19 | 1997-01-18 | 1997-07-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2000-07-19 | 2001-01-18 | 2001-07-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2004-07-19 | 2005-01-18 | 2005-07-20 | $7700.00 | Window Closed / Lapsed |