US6153252A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for coating stents
Assignee: Cordis US Corp
•
Filing: 1999-04-19
•
Granted: 2000-11-28
•
Expires: 2019-04-19
Abstract
Abstract A process is provided for coating stents having a first and second surface with passages there between to avoid blockage and bridging of the passages. The process comprises contacting the stent with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent while maintaining a fluid flow through said passages sufficient prevent the film forming biocompatible polymer from substantially blocking said passages. Also described are stents coated by this process.
Inventors
- 👤 Syed F. A. Hossainy
- 👤 Mark B. Roller
- 👤 Gerard H. Llanos
- 👤 Gregory A. Kopia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:05
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61L; A61L31/00; A61L31/08; A61L31/10; A61L31/14; A61L31/16; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0047; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/60; A61L2300/606; A61L2420/00; A61L2420/02
Claims Analysis
Total Claims: 40
Claim 1
Independent Claim
136 words
A method for coating a stent having an outer surface and inner surface with passages between the outer surface and inner surfaces comprising: (a) contacting the stent with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent; (b) before the coating solution dries creating fluid movement out of the passages of the stent sufficient to prevent the film forming biocompatible polymers from substantially blocking said passages thereafter; (c) drying the stent to provide at least a partially coated stent with a first coating wherein said fluid movement is created by contacting a mandrel with the inner surface of the stent and moving the mandrel relative to the stent to prevent bridges from forming in said passages.
Claim 2
Independent Claim
136 words
A method for coating a stent having an outer surface and inner surface with passages between the outer surface and inner surfaces comprising: (a) contacting the stent with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent; (b) before the coating solution dries creating fluid movement out of the passages of the stent sufficient to prevent the film forming biocompatible polymers from substantially blocking said passages thereafter; (c) drying the stent to provide at least a partially coated stent with a first coating wherein said fluid movement is created by contacting a mandrel with the inner surface of the stent and moving the mandrel relative to the stent to prevent bridges from forming in said passages.
Claim 3
Dependent Claim
22 words
The method of claim 1 wherein the stent is contacted with the coating solution by dipping the stent into the coating solution.
Claim 4
Dependent Claim
23 words
The method of claim 1 wherein the stent is contacted with the coating solution by spraying the coating solution on to the stent.
Claim 5
Dependent Claim
41 words
The method of claim 2 wherein fluid movement is created by contacting the outer surface of the stent with the inner surface of a tube and moving the tube relative to the stent to prevent bridges from forming in said passages.
Claim 6
Dependent Claim
41 words
The method of claim 3 wherein fluid movement is created by contacting the outer surface of the stent with the inner surface of a tube and moving the tube relative to the stent to prevent bridges from forming in said passages.
Claim 7
Dependent Claim
40 words
The method of claim 1 wherein the film forming biocompatible polymer is selected from the group consisting of aliphatic polyesters, poly(amino acids), copoly(ether-esters), polyalkylenes oxalates, polyamides, poly(iminocarbonates), polyorthoesters, polyoxaesters, polyamidoesters, polyoxaesters containing amido groups, poly(anhydrides), polyphosphazenes, biomolecules and blends thereof.
Claim 8
Dependent Claim
15 words
The method of claim 1 wherein the film forming polymer is a biocompatible aliphatic polyester.
Claim 9
Dependent Claim
16 words
The method of claim 7 wherein the film forming polymer is an elastomeric, biocompatible aliphatic polyester.
Claim 10
Dependent Claim
66 words
The method of claim 8 wherein the elastomeric, bicompatible aliphatic polyester is selected from the group consisting of elastomeric copolymers of ε-caprolactone and glycolide, elastomeric copolymers of ε-caprolactone and lactide, elastomeric copolymers of p-dioxanone and lactide, elastomeric copolymers of ε-caprolactone and p-dioxanone, elastomeric copolymers of p-dioxanone and trimethylene carbonate, elastomeric copolymers of trimethylene carbonate and glycolide, elastomeric copolymer of trimethylene carbonate and lactide and blends thereof.
Claim 11
Dependent Claim
17 words
The method of claim 1 wherein additionally contained in the coating solution is a pharmaceutically active compound.
Claim 12
Dependent Claim
51 words
The method of claim 10 wherein the pharmaceutically active compound is selected from the group consisting of antiproliferative/antimitotic agents, antibiotics, enzymes, antiproliferative/antimitotic alkylating agents, antiproliferative/antimitotic antimetabolites; hormones; anticoaglants; fibrinolytic agents; antiplatelet agents; antimigratory agents; antisecretory agents; antiinflammatory agents; immunosuppressive agents; angiogenic agents; nitric oxide donors; anti-sense olgio nucleotides and combinations thereof.
Claim 13
Dependent Claim
12 words
The method of claim 11 wherein the pharmaceutically active compound is rapamycin.
Claim 14
Dependent Claim
16 words
The method of claim 1 wherein after the stent is dried a second coating is applied.
Claim 15
Dependent Claim
29 words
The method of claim 13 wherein the second coating is applied by spraying a solution containing a film forming biocompatible polymer onto at least one surface of the stent.
Claim 16
Dependent Claim
21 words
The method of claim 13 wherein the second coating contains a film forming biocompatible polymer not present in the first coating.
Claim 17
Independent Claim
115 words
A method for coating a tubular stent having a first surface and second surface with passages between the first surface and second surfaces comprising; (a) placing the tubular stent on a mandrel; then (b) contacting the stent and mandrel with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent while moving the stent relative to the mandrel to cause fluid flow through said passages sufficient to prevent the film forming biocompatible polymer from substantially blocking said passages; thereafter (c) drying the stent to provide at least a partially coated tubular stent with a first coating.
Claim 18
Independent Claim
115 words
A method for coating a tubular stent having a first surface and second surface with passages between the first surface and second surfaces comprising; (a) placing the tubular stent on a mandrel; then (b) contacting the stent and mandrel with a liquid coating solution containing a film forming biocompatible polymer under conditions suitable to allow the film forming biocompatible polymer to coat at least one surface of the stent while moving the stent relative to the mandrel to cause fluid flow through said passages sufficient to prevent the film forming biocompatible polymer from substantially blocking said passages; thereafter (c) drying the stent to provide at least a partially coated tubular stent with a first coating.
Claim 19
Dependent Claim
41 words
The method of claim 16 wherein the film forming biocompatible polymer is selected from the group consisting of of aliphatic polyesters, poly(amino acids), copoly(ether-esters), polyalkylenes oxalates, polyamides, poly(iminocarbonates), polyorthoesters, polyoxaesters, polyamidoesters, polyoxaesters containing amido groups, poly(anhydrides), polyphosphazenes, biomolecules and blends thereof.
Claim 20
Dependent Claim
15 words
The method of claim 16 wherein the stent is coated with an elastomeric aliphatic polyester.
Claim 21
Dependent Claim
66 words
The method of claim 18 wherein the elastomeric, bicompatible aliphatic polyester is selected from the group consisting of elastomeric copolymers of ε-caprolactone and glycolide, elastomeric copolymers of ε-caprolactone and lactide, elastomeric copolymers of p-dioxanone and lactide, elastomeric copolymers of ε-caprolactone and p-dioxanone, elastomeric copolymers of p-dioxanone and trimethylene carbonate, elastomeric copolymers of trimethylene carbonate and glycolide, elastomeric copolymer of trimethylene carbonate and lactide and blends thereof.
Claim 22
Dependent Claim
11 words
The method of claim 19 wherein the elasomertic polyester is ε-caprolactone-co-glycolide.
Claim 23
Dependent Claim
11 words
The method of claim 20 wherein a second coating is applied.
Claim 24
Dependent Claim
17 words
The method of claim 21 wherein the first coating is ε-caprolactone-co-glycolide and the second coating is ε-caprolactone-co-glycolide.
Claim 25
Dependent Claim
14 words
The method of claim 22 wherein the first coating contains a pharmaceutically active compound.
Claim 26
Dependent Claim
11 words
The method of claim 19 wherein the elasomertic polyester is ε-caprolactone-co-lactide.
Claim 27
Dependent Claim
11 words
The method of claim 24 wherein a second coating is applied.
Claim 28
Dependent Claim
17 words
The method of claim 25 wherein the first coating is ε-caprolactone-co-lactide and the second coating is ε-caprolactone-co-lactide.
Claim 29
Dependent Claim
17 words
The method of claim 25 wherein the first coating is ε-caprolactone-co-lactide and the second coating is ε-caprolactone-co-glycolide.
Claim 30
Dependent Claim
14 words
The method of claim 26 wherein the first coating contains a pharmaceutically active compound.
Claim 31
Dependent Claim
14 words
The method of claim 27 wherein the first coating contains a pharmaceutically active compound.
Claim 32
Dependent Claim
12 words
The method of claim 26 wherein the pharmaceutically active compound is rapamycin.
Claim 33
Dependent Claim
12 words
The method of claim 27 wherein the pharmaceutically active compound is rapamycin.
Claim 34
Dependent Claim
13 words
The method of claim 6 wherein additionally present is a biocompatible hydrophilic polymer.
Claim 35
Dependent Claim
30 words
The method of claim 31 wherein the biocompatible hydrophilic polymer is selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyethylene glycol, carboxylmethyl cellulose, hydroxymethyl cellulose and combination thereof.
Claim 36
Dependent Claim
26 words
The method of claim 25 wherein the second coating is a coating applied to modulate the release rate of the pharmaceutical agent in the first coating.
Claim 37
Dependent Claim
18 words
The method of claim 34 wherein the second coating weights between about 10 micrograms and about 2000 micrograms.
Claim 38
Dependent Claim
18 words
The method of claim 34 wherein the second coating weights between about 100 micrograms and about 1700 micrograms.
Claim 39
Dependent Claim
14 words
The method of claim 21 wherein additionally present are at least two top coats.
Claim 40
Dependent Claim
14 words
The method of claim 21 wherein additionally present are at least three top coats.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2003-11-28 | 2004-05-29 | 2004-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2007-11-28 | 2008-05-29 | 2008-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2011-11-28 | 2012-05-29 | 2012-11-28 | $7700.00 | Window Closed / Lapsed |