US4749585A
Expired / Lapsed
US
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Antibiotic bonded prosthesis and process for producing same
Assignee: Rutgers, The State University of New Jersey
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Filing: 1986-04-11
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Granted: 1988-06-07
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Expires: 2006-04-11
Abstract
Abstract There is disclosed an improved prosthesis coated, respectively, with an ionic surfactant, an antibiotic and/or antithrombiotic agent and treated with an immobilizing ionic exchange compound, to remove un-antibiotic bound ionic surfactant. The drug may be encapsulated within phospholipid vesicles which are bound to the prosthesis.
Inventors
- 👤 Ralph S. Greco
- 👤 Richard A. Harvey
- 👤 Stanley Z. Trooskin
- 👤 George Strauss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:26
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61K; A61K9/00; A61K9/10; A61K9/127; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0017; A61L33/0047; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/60; A61L2300/606; A61L2300/62; A61L2300/626; A61L2300/80; A61L2300/802; Y; Y10; Y10T; Y10T428/00; Y10T428/31504; Y10T428/3154; Y10T428/31544; Y10T428/31678
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
38 words
A prosthesis for use in in vivo surgery having a coating, respectively, of an ionically charged surfactant and an antibiotic compound encapsulated within phospholipid vesicles, wherein said vesicles have a surface charge opposite to that of said surfactant.
Claim 2
Dependent Claim
38 words
A prosthesis for use in in vivo surgery having a coating, respectively, of an ionically charged surfactant and an antibiotic compound encapsulated within phospholipid vesicles, wherein said vesicles have a surface charge opposite to that of said surfactant.
Claim 3
Dependent Claim
21 words
The prothesis as defined in claim 1 wherein said antibiotic compound is selected from the group consisting of penicillins, and cefoxitins.
Claim 4
Dependent Claim
14 words
The prosthesis as defined in claim 1 wherein said surfactant is tridodecylmethyl ammonium chloride.
Claim 5
Dependent Claim
15 words
The prosthesis as defined in claim 3 wherein said vesicles are prepared from phosphatidyl serine.
Claim 6
Dependent Claim
14 words
The prosthesis as defined in claim 1 wherein said prosthesis is a vascular graft.
Claim 7
Independent Claim
55 words
A method for preparing a prosthesis for use in in vivo surgery, which comprises: (a) contacting said prosthesis with an ionically charged surfactant to coat said prosthesis with said ionically charged surfactant; (b) contacting said prosthesis of step (a) with a phospholipid vesicle suspension; and (c) removing non-adhering vesicles from the prosthesis of step (b).
Claim 8
Independent Claim
55 words
A method for preparing a prosthesis for use in in vivo surgery, which comprises: (a) contacting said prosthesis with an ionically charged surfactant to coat said prosthesis with said ionically charged surfactant; (b) contacting said prosthesis of step (a) with a phospholipid vesicle suspension; and (c) removing non-adhering vesicles from the prosthesis of step (b).
Claim 9
Dependent Claim
23 words
The method as defined in claim 6 wherein step (a) is effected for a period of time of from 5 to 120 minutes.
Claim 10
Dependent Claim
18 words
The method as defined in claim 6 wherein step (a) is effected for a period of 30 minutes.
Claim 11
Dependent Claim
23 words
The method as defined in claim 6 wherein step (a) is effected at a temperature of from 0 degrees to 55 degrees C.
Claim 12
Dependent Claim
16 words
The method as defined in claim 9 wherein step (a) is effected preferably at ambient temperature.
Claim 13
Dependent Claim
18 words
The method as defined in claim 6 wherein step (b) is effected for 16 hours at room temperature.
Claim 14
Dependent Claim
25 words
The method as defined in claim 6 wherein the phospholipid vesicle suspension is prepared by sonicating phospholipids suspended in an aqueous solution of a drug.
Claim 15
Dependent Claim
27 words
The method as defined in claim 12 wherein a phosphlipid with a net positive charge is employed if the prosthesis has been coated with negatively charged surfactant.
Claim 16
Dependent Claim
28 words
The method as defined in claim 12 wherein a phospholipid with a net negative charge is employed if the prosthesis has been coated with a positively charged surfactant.
Claim 17
Dependent Claim
22 words
The method as defined in claim 12 wherein the suspension is sonicated with a probe-type sonicator at 5 watts to 50 watts.
Claim 18
Dependent Claim
18 words
The method as defined in claim 15 wherein the suspension is sonicated preferably at 20 watts of energy.
Claim 19
Dependent Claim
15 words
The method as defined in claim 12 wherein the suspension is sonicated for 60 minutes.
Claim 20
Dependent Claim
19 words
The method as defined in claim 17 wherein the suspension is sonicated at a temperature of 25 degrees C.
Claim 21
Dependent Claim
15 words
The method as defined in claim 6 wherein said cationic surfactant is tridodecylmethyl ammonium chloride.
Claim 22
Dependent Claim
21 words
The method as defined in claim 6 wherein said antibiotic compound is selected from the group consisting of penicillins and cephalosporins.
References Cited (Backward Citations)
US4442133A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-07 | 1991-12-07 | 1992-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-07 | 1995-12-07 | 1996-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-07 | 1999-12-07 | 2000-06-07 | $7700.00 | Window Closed / Lapsed |