US5607475A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatible medical article and method
Assignee: Medtronic Inc
•
Filing: 1995-08-22
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Granted: 1997-03-04
•
Expires: 2015-08-22
Abstract
Abstract A medical article having a metal or glass surface with the surface having an adherent coating of improved biocompatibility. The coating is made by first applying to the surface an silane compound having a pendant vinyl functionality such that the silane adheres to the surface and then, in a separate step, forming a graft polymer on the surface with applied vinylsilane such that the pendant vinyl functionality of the vinylsilane is incorporated into the graft polymer by covalent bonding with the polymer. Biomolecules may then be covalently attached to the base layer.
Inventors
- 👤 Linda L. Cahalan
- 👤 Patrick T. Cahalan
- 👤 Michel Verhoeven
- 👤 Marc Hendriks
- 👤 Benedicte Fouache
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:45
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0047; A61L27/00; A61L27/28; A61L27/34; A61L31/00; A61L31/08; A61L31/10; A61L33/0011; A61L33/0029; Y; Y10; Y10S; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
117 words
An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising: (a) a silane which includes a vinyl functionality, the silane adherent to the metal surface such that the vinyl functionality is pendant from the surface; (b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid; (c) a polyamine spacer covalently attached to the graft polymer; and (d) a biomolecule covalently attached to the spacer.
Claim 2
Dependent Claim
117 words
An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising: (a) a silane which includes a vinyl functionality, the silane adherent to the metal surface such that the vinyl functionality is pendant from the surface; (b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid; (c) a polyamine spacer covalently attached to the graft polymer; and (d) a biomolecule covalently attached to the spacer.
Claim 3
Dependent Claim
23 words
The endoprosthesis of claim 1, wherein the silane includes a functional group selected from the group consisting of halogen, methoxy and ethoxy groups.
Claim 4
Dependent Claim
12 words
An endoprosthesis as in claim 2, in which the silane is trichlorovinylsilane.
Claim 5
Dependent Claim
14 words
An endoprosthesis as in claim 1, in which the polyamine spacer is a polyalkyleneimine.
Claim 6
Dependent Claim
13 words
An endoprosthesis as in claim 1, in which the biomolecule is an antithrombotic.
Claim 7
Dependent Claim
21 words
An endoprosthesis as in claim 5, in which the antithrombotic is selected from the group consisting of heparin and heparin derivatives.
Claim 8
Dependent Claim
128 words
An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising: (a) a silane having the structure C.sub.2 H.sub.3 --R--Si--X.sub.3, wherein X is a halogen, methoxy or ethoxy group and R is an optional short chain alkyl group, the silane adherent to the metal surface such that the vinyl functional group is pendant from the surface; (b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid; and (c) a biomolecule covalently attached to the graft polymer.
Claim 9
Dependent Claim
128 words
An endoprosthesis having a metal surface contacting body fluids, the metal surface having a coating thereon comprising: (a) a silane having the structure C.sub.2 H.sub.3 --R--Si--X.sub.3, wherein X is a halogen, methoxy or ethoxy group and R is an optional short chain alkyl group, the silane adherent to the metal surface such that the vinyl functional group is pendant from the surface; (b) a graft polymer, the graft polymer covalently bonded with the pendant vinyl functionality of the adherent silane, the graft polymer simultaneously formed and bonded to the pendant vinyl functionality by free radical reaction initiated by an oxidizing metal with at least one ethylenically unsaturated monomer selected from the group consisting of acrylamide and acrylic acid; and (c) a biomolecule covalently attached to the graft polymer.
Claim 10
Dependent Claim
17 words
The endoprosthesis of claim 7, wherein the biomolecule is covalently attached by means of an amine spacer.
Claim 11
Dependent Claim
13 words
The endoprosthesis of claim 8, wherein the amine spacer is a crosslinked polyalkyeneimine.
Claim 12
Dependent Claim
12 words
The endoprosthesis as in claim 7, in which the silane is trichlorovinylsilane.
Claim 13
Dependent Claim
12 words
The endoprosthesis of claim 7, wherein the biomolecule comprises an antithrombotic agent.
Claim 14
Dependent Claim
19 words
The endoprosthesis of claim 11, wherein the antithrombotic is selected from the group consisting of heparin and heparin derivatives.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2000-03-03 | 2000-09-02 | 2001-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2004-03-03 | 2004-09-02 | 2005-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2008-03-03 | 2008-09-02 | 2009-03-04 | $7700.00 | Window Closed / Lapsed |