US5415938A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Biocompatability of solid surfaces
Assignee: Medtronic Inc
•
Filing: 1994-02-09
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Granted: 1995-05-16
•
Expires: 2014-02-09
Abstract
Abstract An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkyaimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
Inventors
- 👤 Patrick T. Cahalan
- 👤 Michel Verhoeven
- 👤 Marc Hendriks
- 👤 Linda Cahalan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 22:02
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; A61L33/0041; A61L33/0029; Y; Y10; Y10T; Y10T428/00; Y10T428/31; Y10T428/31504; Y10T428/31551; Y10T428/31562; Y10T428/31721; Y10T428/31942; Y10T428/31946
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
84 words
A spacer for attaching a biomolecule to a solid surface comprising, in combination: (a) an aminated substrate including acrylamide graft polymerized onto the substrate anal spaced pendant amine groups extending from the graft polyacrylamide and covalently attached to the graft polyacrylamide; (b) a polyalkylimine covalently attached to the pendant amine groups of the aminated substrate; and (c) a crosslinking agent which is at least difunctional in aldehyde groups providing the covalent attachment of the polyalkylimine to the pendant amine groups of the aminated substrate.
Claim 2
Dependent Claim
84 words
A spacer for attaching a biomolecule to a solid surface comprising, in combination: (a) an aminated substrate including acrylamide graft polymerized onto the substrate anal spaced pendant amine groups extending from the graft polyacrylamide and covalently attached to the graft polyacrylamide; (b) a polyalkylimine covalently attached to the pendant amine groups of the aminated substrate; and (c) a crosslinking agent which is at least difunctional in aldehyde groups providing the covalent attachment of the polyalkylimine to the pendant amine groups of the aminated substrate.
Claim 3
Dependent Claim
11 words
The spacer according to claim 1 wherein the polyalkylimine is polyethyleneimine.
Claim 4
Dependent Claim
25 words
The spacer according to claim 1 wherein the crosslinking agent is selected from the group consisting of glutaraldehyde, glyoxal, malonaldehyde, succinaldehyde, adipaldehyde, and dialdehyde starch.
Claim 5
Dependent Claim
23 words
The spacer according to claim 1 wherein the pendant amine groups are provided by amine-functional spacer molecules covalently attached to the grafted acrylamide.
Claim 6
Dependent Claim
24 words
The spacer according to claim 1 wherein the polyalkylimine is also crosslinked by a crosslinking agent which is at least difunctional in aldehyde groups.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1998-05-15 | 1998-11-14 | 1999-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2002-05-15 | 2002-11-14 | 2003-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-05-15 | 2006-11-14 | 2007-05-16 | $7700.00 | Window Closed / Lapsed |