US5820918A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medical devices containing in-situ generated medical compounds
Assignee: Boston Scientific Scimed Inc
•
Filing: 1996-07-11
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Granted: 1998-10-13
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Expires: 2016-07-11
Abstract
Abstract A process for impregnating a medical device made from a water absorbable polymer material, e.g., a hydrogel, with a medical compound having low solubility in aqueous solutions, e.g., an antiseptic or radiopaque compound, is disclosed. The device is first infiltrated with an aqueous solution containing a first water soluble, ionizable compound, and subsequently infiltrated with an aqueous solution containing a second water soluble, ionizable compound. The ionizable compounds are selected such that they react after mutual contact to form the medical compound in-situ within the device.
Inventors
- 👤 John M. Ronan
- 👤 Samuel A. Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 17:21
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/50; A61L27/54; A61L29/00; A61L29/14; A61L29/16; A61L29/18; A61L31/00; A61L31/14; A61L31/16; A61L31/18; A61L2300/00; A61L2300/10; A61L2300/102; A61L2300/104; A61L2300/40; A61L2300/404; Y; Y10; Y10S; Y10S623/00; Y10S623/924
Claims Analysis
Total Claims: 53
Claim 1
Independent Claim
191 words
A process for impregnating a medical device comprising a water absorbable polymer material with a medical compound having water solubility less than about 0.5 g/liter comprising: a) contacting at least a portion of said device with a first aqueous solution containing a first water soluble ionizable compound dissolved therein such that the contacted portion of said device is infiltrated by said first aqueous solution; b) contacting said portion of said device with a second aqueous solution containing a second water soluble ionizable compound dissolved therein such that the contacted portion of said device is also infiltrated by said second aqueous solution; said water soluble compounds characterized by the fact that the ions thereof react after contact to form said medical compound having water solubility less than about 0.5 g/liter within said device, said water absorbable polymer material comprising ionically or covalently crosslinked hydrogel; and said medical compound being selected from the group consisting of radiopaque compounds present in said device at a level of from about 5 to about 15 wt % and antiseptic agents present in said device at a level of from about 0.01 to about 5 wt %.
Claim 2
Dependent Claim
191 words
A process for impregnating a medical device comprising a water absorbable polymer material with a medical compound having water solubility less than about 0.5 g/liter comprising: a) contacting at least a portion of said device with a first aqueous solution containing a first water soluble ionizable compound dissolved therein such that the contacted portion of said device is infiltrated by said first aqueous solution; b) contacting said portion of said device with a second aqueous solution containing a second water soluble ionizable compound dissolved therein such that the contacted portion of said device is also infiltrated by said second aqueous solution; said water soluble compounds characterized by the fact that the ions thereof react after contact to form said medical compound having water solubility less than about 0.5 g/liter within said device, said water absorbable polymer material comprising ionically or covalently crosslinked hydrogel; and said medical compound being selected from the group consisting of radiopaque compounds present in said device at a level of from about 5 to about 15 wt % and antiseptic agents present in said device at a level of from about 0.01 to about 5 wt %.
Claim 3
Dependent Claim
22 words
The process of claim 1 wherein said water soluble, ionizable compounds are selected from the group consisting of organic or inorganic salts.
Claim 4
Dependent Claim
15 words
The process of claim 1 wherein said polymer material comprises a crosslinked ionic polymer hydrogel.
Claim 5
Dependent Claim
18 words
The process of claim 3 wherein said crosslinked ionic polymer hydrogel comprises anionic polymer crosslinked with crosslinking cations.
Claim 6
Dependent Claim
42 words
The process of claim 4 wherein said anionic polymer is selected from the group consisting of polyacrylic acid, polymethacrylic acid, alginic acid, pectinic acid, carboxyl methyl cellulose, hyaluronic acid, heparin, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, and chondroitin sulfate, and salts thereof.
Claim 7
Dependent Claim
27 words
The process of claim 5 wherein said anionic polymer is selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid and salts thereof.
Claim 8
Dependent Claim
30 words
The process of claim 4 wherein said crosslinking cations are selected from the group consisting of calcium, magnesium, barium, strontium, boron, beryllium, aluminum, iron, copper, cobalt, lead and silver ions.
Claim 9
Dependent Claim
22 words
The process of claim 7 wherein said crosslinking cations are selected from the group consisting of calcium, barium, iron and aluminum ions.
Claim 10
Dependent Claim
18 words
The process of claim 3 wherein said crosslinked ionic polymer hydrogel comprises cationic polymer crosslinked with crosslinking anions.
Claim 11
Dependent Claim
29 words
The process of claim 9 wherein said crosslinked cationic polymer comprises at least one polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 12
Dependent Claim
25 words
The process of claim 9 wherein said crosslinking anions are selected from the group consisting of phosphate, citrate, borate, succinate, maleate, adipate and oxalate ions.
Claim 13
Dependent Claim
29 words
The process of claim 1 wherein said medical compound is a radiopaque compound present in said device at a level of from about 5 to about 15 wt %.
Claim 14
Dependent Claim
21 words
The process of claim 12 wherein said radiopaque compound contains a metal having an atomic weight of greater than about 40.
Claim 15
Dependent Claim
27 words
The process of claim 13 wherein said metal is selected from the group consisting of barium, strontium, iron, copper, lead, tin, zinc, gold, silver, bismuth and manganese.
Claim 16
Dependent Claim
10 words
The process of claim 14 wherein said metal is barium.
Claim 17
Dependent Claim
29 words
The process of claim 1 wherein the medical compound is an antiseptic agent present in said device at a level of from about 0.01 to about 5 wt %.
Claim 18
Dependent Claim
11 words
The process of claim 16 wherein said antiseptic agent contains silver.
Claim 19
Dependent Claim
27 words
The process of claim 16 wherein said antiseptic agent is selected from the group consisting of silver chloride, silver carbonate, silver citrate, silver iodide and silver nitrite.
Claim 20
Dependent Claim
29 words
The process of claim 1 wherein said first and second water soluble ionizable compounds have a solubility in aqueous solution at room temperature of at least about 0.1 g/liter.
Claim 21
Dependent Claim
14 words
The process of claim 19 wherein said solubility is at least about 5 g/liter.
Claim 22
Dependent Claim
24 words
The process of claim 19 wherein said medical compound has a solubility in aqueous solution at room temperature of less than about 0.1 g/liter.
Claim 23
Dependent Claim
13 words
The process of claim 21 said solubility is less than about 0.05 g/liter.
Claim 24
Dependent Claim
14 words
The process of claim 1 wherein said medical device is a pre-shaped medical device.
Claim 25
Dependent Claim
27 words
The process of claim 1 wherein said medical device is selected from the group consisting of stents, catheters or cannulas, plugs, constrictors and tissue or biological encapsulants.
Claim 26
Dependent Claim
18 words
The process of claim 1 wherein said medical device is contacted with each of said solutions by immersion.
Claim 27
Dependent Claim
26 words
The process of claim 1 including the step: c) washing said device after step (b) with water to remove excess water soluble ions from said device.
Claim 28
Dependent Claim
11 words
An impregnated medical device prepared by the process of claim 1.
Claim 29
Dependent Claim
22 words
The device of claim 27 wherein said water soluble, ionizable compounds are selected from the group consisting of organic or inorganic salts.
Claim 30
Dependent Claim
15 words
The device of claim 27 wherein said polymer material comprises a crosslinked ionic polymer hydrogel.
Claim 31
Dependent Claim
18 words
The device of claim 29 wherein said crosslinked ionic polymer hydrogel comprises anionic polymer crosslinked with crosslinking cations.
Claim 32
Dependent Claim
42 words
The device of claim 30 wherein said anionic polymer is selected from the group consisting of polyacrylic acid, polymethacrylic acid, alginic acid, pectinic acid, carboxyl methyl cellulose, hyaluronic acid, heparin, carboxymethyl starch, carboxymethyl dextran, heparin sulfate, and chondroitin sulfate, and salts thereof.
Claim 33
Dependent Claim
27 words
The device of claim 31 wherein said anionic polymer is selected from the group consisting of alginic acid, pectinic acid, carboxymethyl cellulose, hyaluronic acid and salts thereof.
Claim 34
Dependent Claim
30 words
The device of claim 30 wherein said crosslinking cations are selected from the group consisting of calcium, magnesium, barium, strontium, boron, beryllium, aluminum, iron, copper, cobalt, lead and silver ions.
Claim 35
Dependent Claim
22 words
The device of claim 33 wherein said crosslinking cations are selected from the group consisting of calcium, barium, iron and aluminum ions.
Claim 36
Dependent Claim
18 words
The device of claim 29 wherein said crosslinked ionic polymer hydrogel comprises cationic polymer crosslinked with crosslinking anions.
Claim 37
Dependent Claim
29 words
The device of claim 35 wherein said crosslinked cationic polymer comprises at least one polymer selected from the group consisting of chitosan, cationic guar, cationic starch and polyethylene amine.
Claim 38
Dependent Claim
25 words
The device of claim 35 wherein said crosslinking anions are selected from the group consisting of phosphate, citrate, borate, succinate, maleate, adipate and oxalate ions.
Claim 39
Dependent Claim
29 words
The device of claim 27 wherein said medical compound is a radiopaque compound present in said device at a level of from about 5 to about 15 wt %.
Claim 40
Dependent Claim
21 words
The device of claim 38 wherein said radiopaque compound contains a metal having an atomic weight of greater than about 40.
Claim 41
Dependent Claim
27 words
The device of claim 39 wherein said metal is selected from the group consisting of barium, strontium, iron, copper, lead, tin, zinc, gold, silver, bismuth and manganese.
Claim 42
Dependent Claim
10 words
The device of claim 40 wherein said metal is barium.
Claim 43
Dependent Claim
29 words
The device of claim 27 wherein said medical compound is an antiseptic agent present in said device at a level of from about 0.01 to about 5 wt %.
Claim 44
Dependent Claim
11 words
The device of claim 42 wherein said antiseptic agent contains silver.
Claim 45
Dependent Claim
27 words
The device of claim 42 wherein said antiseptic agent is selected from the group consisting of silver chloride, silver carbonate, silver citrate, silver iodide and silver nitrite.
Claim 46
Dependent Claim
29 words
The device of claim 27 wherein said first and second water soluble ionizable compounds have a solubility in aqueous solution at room temperature of at least about 0.1 g/liter.
Claim 47
Dependent Claim
14 words
The device of claim 45 wherein said solubility is at least about 5 g/liter.
Claim 48
Dependent Claim
24 words
The device of claim 45 wherein said medical compound has a solubility in aqueous solution at room temperature of less than about 0.1 g/liter.
Claim 49
Dependent Claim
13 words
The device of claim 47 said solubility is less than about 0.05 g/liter.
Claim 50
Dependent Claim
11 words
The device of claim 27 which is a pre-shaped medical device.
Claim 51
Dependent Claim
24 words
The device of claim 27 which is selected from the group consisting of stents, catheters or cannulas, plugs, constrictors and tissue or biological encapsulants.
Claim 52
Dependent Claim
15 words
The device of claim 27 which is contacted with each of said solutions by immersion.
Claim 53
Dependent Claim
31 words
The device of claim 27 which is prepared by the further step of: (c) washing said device after step (b) with water to remove excess water soluble ions from said device.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 2001-10-12 | 2002-04-13 | 2002-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2005-10-12 | 2006-04-13 | 2006-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2009-10-12 | 2010-04-13 | 2010-10-13 | $7700.00 | Window Closed / Lapsed |