US4527293A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Hydrogel surface of urological prosthesis
Assignee: MIAMI 14455 SW 85TH ST MIAMI FL 33101, University of
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Filing: 1983-05-18
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Granted: 1985-07-09
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Expires: 2003-05-18
Abstract
Abstract Disclosed is a urological device comprising a polymeric prosthesis coated on its surface by a grafted or interpenetrated hydrogel copolymer comprising 2-hydroxyethyl methacrylate, methacrylic acid, and a crosslinking agent, wherein each constituent of said copolymer is present in an amount selected from a defined range of mole fraction %. The hydrogel exhibits a shrink/swell behavior which varies with changing urine composition such that the polymer undergoes swelling and collapse in rapid response to said change and thereby prevents calcium encrustation. Also disclosed is a method for making the device.
Inventors
- 👤 Eugene C. Eckstein
- 👤 Norman L. Block
- 👤 Jacob Kline
- 👤 Leonard Pinchuk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:48
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/28; A61L27/34; Y; Y10; Y10S; Y10S524/00; Y10S524/916
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
56 words
A physiologically compatible urological prosthesis having a urine-contacting hydrogel copolymer surface of a thickness between about 50 Å and 1 mm, said hydrogel copolymer comprising between about 1 and about 3 mole fraction % of methacrylic acid and between about 0.01 and 0.5 mole fraction % of a crosslinking agent, wherein the remainder is 2-hydroxyethyl methacrylate.
Claim 2
Dependent Claim
56 words
A physiologically compatible urological prosthesis having a urine-contacting hydrogel copolymer surface of a thickness between about 50 Å and 1 mm, said hydrogel copolymer comprising between about 1 and about 3 mole fraction % of methacrylic acid and between about 0.01 and 0.5 mole fraction % of a crosslinking agent, wherein the remainder is 2-hydroxyethyl methacrylate.
Claim 3
Dependent Claim
17 words
The prosthesis of claim 1 wherein said coating is between about 1 and about 30 microns thick.
Claim 4
Dependent Claim
16 words
The prosthesis of claim 1 wherein said prosthesis has been fabricated from a material comprising polyurethane.
Claim 5
Dependent Claim
17 words
The prosthesis of claim 1 wherein said crosslinking agent in said hydrogel copolymer surface is tetraethyleneglycol dimethacrylate.
Claim 6
Dependent Claim
28 words
The prosthesis of claim 1 wherein said methacrylic acid is present in said hydrogel copolymer surface in an amount between about 2 and about 2.5 mole fraction %.
Claim 7
Dependent Claim
99 words
A process for making a urine-contacting physiological compatible article, comprising the steps of: A. purifying 2-hydroxyethyl methacrylate; B. adding to said purified 2-hydroxyethyl methacrylate a solvent and from between about 1 and about 3 mole fraction % of methacrylic acid and from between about 0.01 and about 0.5 mole fraction % of a crosslinking agent to form a solution; C. forming a hydrogel coating on the urine-contacting surface of a polymeric urological prosthesis by exposing said device to said solution and causing a hydrogel copolymer comprising said 2-hydroxyethyl methacrylate, said methacrylic acid, and said crosslinking agent to form thereon.
Claim 8
Dependent Claim
99 words
A process for making a urine-contacting physiological compatible article, comprising the steps of: A. purifying 2-hydroxyethyl methacrylate; B. adding to said purified 2-hydroxyethyl methacrylate a solvent and from between about 1 and about 3 mole fraction % of methacrylic acid and from between about 0.01 and about 0.5 mole fraction % of a crosslinking agent to form a solution; C. forming a hydrogel coating on the urine-contacting surface of a polymeric urological prosthesis by exposing said device to said solution and causing a hydrogel copolymer comprising said 2-hydroxyethyl methacrylate, said methacrylic acid, and said crosslinking agent to form thereon.
Claim 9
Dependent Claim
18 words
The process of claim 6 wherein said coating is between about 50 Å and about 1 mm thick.
Claim 10
Dependent Claim
17 words
The process of claim 7 wherein said coating is between about 1 and about 30 microns thick.
Claim 11
Dependent Claim
10 words
The process of claim 6 wherein said prosthesis comprises polyurethane.
Claim 12
Dependent Claim
12 words
The process of claim 6 wherein said crosslinking agent is tetraethyleneglycol dimethacrylate.
Claim 13
Dependent Claim
27 words
The process of claim 6 wherein said crosslinking agent is present in an amount between about 0.01 and about 0.5 mole fraction % relative to said copolymer.
Claim 14
Dependent Claim
27 words
The process of claim 6 wherein said methacrylic acid is present in an amount between about 1 and about 3 mole fraction % relative to said copolymer.
Claim 15
Dependent Claim
28 words
The process of claim 12 wherein said methacrylic acid is present in an amount between about 2 and about 2.5 mole fraction % based relative to said copolymer.
Claim 16
Dependent Claim
10 words
The process of claim 6 wherein said solvent is water.
Claim 17
Dependent Claim
104 words
A physiologically compatible article comprising a polymeric urological prosthesis having a urine-contacting surface coating grafted or interpenetrated thereon, wherein said surface coating comprises a copolymer, said article being formed by: A. purifying 2-hydroxyethyl methacrylate; B. adding to said purified 2-hydroxyethyl methacrylate a solvent and from between about 1 and about 3 mole fraction % of methacrylic acid and a crosslinking agent to form a solution; C. forming a hydrogel coating on the surface of said polymeric urological prosthesis by exposing said prosthesis to said solution and causing a hydrogel copolymer comprising said 2-hydroxyethyl methacrylate, said methacrylic acid, and said crosslinking agent to form thereon.
Claim 18
Dependent Claim
104 words
A physiologically compatible article comprising a polymeric urological prosthesis having a urine-contacting surface coating grafted or interpenetrated thereon, wherein said surface coating comprises a copolymer, said article being formed by: A. purifying 2-hydroxyethyl methacrylate; B. adding to said purified 2-hydroxyethyl methacrylate a solvent and from between about 1 and about 3 mole fraction % of methacrylic acid and a crosslinking agent to form a solution; C. forming a hydrogel coating on the surface of said polymeric urological prosthesis by exposing said prosthesis to said solution and causing a hydrogel copolymer comprising said 2-hydroxyethyl methacrylate, said methacrylic acid, and said crosslinking agent to form thereon.
Claim 19
Dependent Claim
18 words
The process of claim 15 wherein said coating is between about 50 Å and about 1 mm thick.
Claim 20
Dependent Claim
17 words
The process of claim 16 wherein said coating is between about 1 and about 30 microns thick.
Claim 21
Dependent Claim
10 words
The process of claim 15 wherein said prosthesis comprises polyurethane.
Claim 22
Dependent Claim
12 words
The process of claim 15 wherein said crosslinking agent is tetraethyleneglycol dimethacrylate.
Claim 23
Dependent Claim
23 words
The process of claim 15 wherein said crosslinking agent is present in an amount between about 0.01 and about 0.5 mole fraction %.
Claim 24
Dependent Claim
27 words
The process of claim 15 wherein said methacrylic acid is present in an amount between about 1 and about 3 mole fraction % relative to said copolymer.
Claim 25
Dependent Claim
28 words
The process of claim 21 wherein said methacrylic acid is present in an amount between about 2 and about 2.5 mole fraction % based relative to said copolymer.
Claim 26
Dependent Claim
10 words
The process of claim 15 wherein said solvent is water.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-07-08 | 1989-01-07 | 1989-07-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-07-08 | 1993-01-07 | 1993-07-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-07-08 | 1997-01-07 | 1997-07-09 | $7700.00 | Window Closed / Lapsed |