US5283257A
Expired / Lapsed
US
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Method of treating hyperproliferative vascular disease
Assignee: Leland Stanford Junior University
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Filing: 1992-07-10
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Granted: 1994-02-01
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Expires: 2012-07-10
Abstract
Abstract This invention provides a method of preventing or treating hyperproliferative vascular disease in a mammal by administering an amount of mycophenolic acid effective to inhibit intimal thickening.
Inventors
- 👤 Clare R. Gregory
- 👤 Randall E. Morris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:20
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/365
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
32 words
A method of preventing or treating hyperproliferative vascular disease in a susceptible mammal, comprising administering to said mammal an amount of mycophenolic acid effective to i it intimal thickening in said mammal.
Claim 2
Independent Claim
32 words
A method of preventing or treating hyperproliferative vascular disease in a susceptible mammal, comprising administering to said mammal an amount of mycophenolic acid effective to i it intimal thickening in said mammal.
Claim 3
Dependent Claim
26 words
The method of claim 1, wherein the administering is accomplished orally, parenterally, intravascularly, intranasally, intrabronchially, transdermally, rectally, or via a vascular stent impregnated with mycophenolic acid.
Claim 4
Dependent Claim
22 words
The method of claim 1, wherein the mycophenolic acid is administered concurrent with said mammal undergoing a percutaneous transluminal coronary angioplasty procedure.
Claim 5
Dependent Claim
23 words
The method of claim 3, which further comprises administering the mycophenolic acid subsequent to said mammal undergoing a percutaneous transluminal coronary angioplasty procedure.
Claim 6
Dependent Claim
26 words
The method of claim 1, wherein the hyperproliferative vascular disease is selected from the group consisting of intimal smooth muscle cell hyperplasia, restenosis, and vascular occlusion.
Claim 7
Dependent Claim
12 words
The method of claim 5, wherein the hyperproliferative vascular disease is restenosis.
Claim 8
Dependent Claim
21 words
The method of claim 6, wherein the mycophenolic acid which is selected is in the form of a pharmaceutically acceptable salt.
Claim 9
Dependent Claim
26 words
The method of claim 1, wherein the mycophenolic acid is administered prior to, concurrent with and/or subsequent to said mammal sustaining a biologically mediated vascular injury.
Claim 10
Dependent Claim
26 words
The method of claim 1, wherein the mycophenolic acid is administered prior to, concurrent with and/or subsequent to said mammal sustaining a mechanically mediated vascular injury.
References Cited (Backward Citations)
US3705946A
Cited
US3880995A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1997-01-31 | 1997-08-02 | 1998-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-01-31 | 2001-08-02 | 2002-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-01-31 | 2005-08-02 | 2006-02-01 | $7700.00 | Window Closed / Lapsed |