Patent US5531791A successfully refreshed from Google Patents.
US5531791A
Expired / Lapsed
US
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Composition for repair of defects in osseous tissues, method of making, and prosthesis
Assignee: Lifenet Health
•
Filing: 1993-07-23
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Granted: 1996-07-02
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Expires: 2013-07-23
Abstract
Abstract A biocompatible collagen/demineralized human bone composite material, method for making the same, and prostheses employing the same are disclosed, wherein the composite material may be formulated into a fluid injectable, gel or rehydratable freeze dried paste. The resultant products can be used either alone or combined with a prosthetic device as an osteoinductive/osteoconductive material.
Inventors
- 👤 Lloyd Wolfinbarger, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:30
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/36; A61L27/38; A61L27/3839; A61L27/3843; A61L27/3847; A61F; A61F2/00; A61F2/02; A61F2/28; A61L27/14; A61L27/22; A61L27/24; A61L27/26; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/40; A61L27/44; A61L27/46; A61F2/30; A61F2002/30001; A61F2002/30316; A61F2002/30535; A61F2002/30581; A61F2002/30583; A61F2210/00; A61F2210/0085; A61F2310/00; A61F2310/00005; A61F2310/00365; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 29
Claim 1
Independent Claim
26 words
A non-immunogenic composition for the promotion of allogenic bone growth and repair in an individual, comprising: demineralized human bone powder, and type-I telopeptide containing human collagen.
Claim 2
Dependent Claim
26 words
A non-immunogenic composition for the promotion of allogenic bone growth and repair in an individual, comprising: demineralized human bone powder, and type-I telopeptide containing human collagen.
Claim 3
Dependent Claim
43 words
A non-immunogenic composition for the promotion of allogenic bone growth and repair in an individual, comprising: demineralized human bone powder, and type-I telopeptide containing human collagen, wherein said human bone powder and said human collagen are derived from the same human cadaver source.
Claim 4
Dependent Claim
43 words
A non-immunogenic composition for the promotion of allogenic bone growth and repair in an individual, comprising: demineralized human bone powder, and type-I telopeptide containing human collagen, wherein said human bone powder and said human collagen are derived from the same human cadaver source.
Claim 5
Dependent Claim
19 words
The non-immunogenic composition of claim 2, wherein said human collagen is derived from tendons and ligaments of said human.
Claim 6
Dependent Claim
24 words
The non-immunogenic composition of claim 2, wherein said type-I telopeptide containing human collagen comprises about 0.25 to 40.00 weight percent of said non-immunogenic composition.
Claim 7
Dependent Claim
55 words
The non-immunogenic composition of claim 2, wherein said type-I telopeptide containing human collagen is produced by the process, comprising: extracting said collagen from said human cadaver source in dilute acid to produce extracted collagen; precipitating said extracted collagen from said acid solution to produce precipitated collagen; and washing said precipitated collagen to form washed collagen.
Claim 8
Dependent Claim
17 words
The non-immunogenic composition of claim 5, wherein said dilute acid comprises one or more dilute organic acids.
Claim 9
Dependent Claim
19 words
The non-immunogenic composition of claim 6, wherein said dilute organic acid has a pH of from 3 to 4.
Claim 10
Dependent Claim
35 words
The non-immunogenic composition of claim 6, wherein said dilute organic acid is one or more member selected from the group consisting of: acetic acid, lactic acid, malic acid, citric acid, glutaric acid, and proprionic acid.
Claim 11
Dependent Claim
14 words
The non-immunogenic composition of claim 8, wherein said dilute organic acid is acetic acid.
Claim 12
Dependent Claim
34 words
The non-immunogenic composition of claim 5, wherein said process further comprises the steps of: resolubilizing said washed collagen to form resolubilized collagen, and dialyzing said resolubilized collagen against isotonic saline to form dialyzed collagen.
Claim 13
Dependent Claim
22 words
The non-immunogenic composition of claim 10, wherein said steps of washing, resolubilizing, and dialyzing, are cyclically repeated from 2 to 6 times.
Claim 14
Dependent Claim
23 words
The non-immunogenic composition of claim 11, wherein said demineralized human bone powder comprises about 20 to 90 weight percent of said non-immunogenic composition.
Claim 15
Dependent Claim
23 words
The non-immunogenic composition of claim 12, wherein said demineralized human bone powder comprises about 30 to 50 weight percent of said non-immunogenic composition.
Claim 16
Dependent Claim
25 words
The non-immunogenic composition of claim 13, wherein said demineralized human bone powder has a particle size of from about 125 microns to about 2 millimeters.
Claim 17
Dependent Claim
25 words
The non-immunogenic composition of claim 14, wherein said demineralized human bone powder has a particle size of from about 125 microns to about 500 microns.
Claim 18
Dependent Claim
25 words
The non-immunogenic composition of claim 14, wherein said demineralized human bone powder has a particle size of from about 250 microns to about 710 microns.
Claim 19
Dependent Claim
24 words
The non-immunogenic composition of claim 14, wherein said demineralized bone powder has a particle size of from about 710 microns to about 2 millimeters.
Claim 20
Dependent Claim
21 words
The non-immunogenic composition of claim 2, wherein said non-immunogenic composition is flowable and injectable, and is a gel or a paste.
Claim 21
Dependent Claim
50 words
The non-immunogenic composition of claim 2, further comprising: one or more elements selected from the group consisting of: a bioactive compound, an antibiotic, an antiviral agent, an antitumor agent, an immunosuppressant agent, a permeation enhancer, a nucleic acid, a mesenchymal element, a gelation enhancing compound and autogenously derived osteoblast cells.
Claim 22
Dependent Claim
37 words
The non-immunogenic composition of claim 19, wherein said bioactive compound is one or more members selected from the group consisting of: bone morphogenetic protein, transforming growth factor β, fibroblast growth factor, insulin, and platelet derived growth factor.
Claim 23
Dependent Claim
11 words
The non-immunogenic composition of claim 19, wherein said antibiotic is penicillin.
Claim 24
Dependent Claim
18 words
The non-immunogenic composition of claim 19, wherein said antiviral agent is a detergent or a peroxide generating agent.
Claim 25
Dependent Claim
29 words
The immunogenic composition of claim 22, wherein said detergent is one or more members selected from the group consisting of: Triton X-100, sodium dodecyl sulfate, Nonidet P-40, and Brij-35.
Claim 26
Dependent Claim
15 words
The non-immunogenic composition of claim 19, wherein said immunosuppressant agent is bovine intestinal choline phosphatase.
Claim 27
Dependent Claim
17 words
The non-immunogenic composition of claim 19, wherein said permeation enhancer is one or more fatty acid esters.
Claim 28
Dependent Claim
28 words
The non-immunogenic composition of claim 25, wherein said fatty acid ester is a mono ester of polyethylene glycol selected from the group consisting of: laureate, myristate and stearate.
Claim 29
Dependent Claim
28 words
The non-immunogenic composition of claim 19, wherein said gelation enhancing compound is a glycosanine glycan selected from the group consisting of: hyaluronic acid, chondroitin sulfate and dermatin sulfate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1999-07-02 | 2000-01-01 | 2000-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2003-07-02 | 2004-01-01 | 2004-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2007-07-02 | 2008-01-01 | 2008-07-02 | $7700.00 | Window Closed / Lapsed |