US5250302A
Expired / Lapsed
US
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Osteogenic devices
Assignee: Creative Biomolecules Inc
•
Filing: 1992-01-28
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Granted: 1993-10-05
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Expires: 2012-01-28
Abstract
Abstract Disclosed are osteogenic devices comprising a matrix containing substantially pure mammalian osteogenic protein and methods of inducing endochondral bone growth in mammals. A partial amino acid sequence, amino acid composition, solubility properties, and various other data characterizing osteogenic protein are also disclosed, as well as a nucleic acid sequences encoding a consensus osteogenic protein.
Inventors
- 👤 Hermann Oppermann
- 👤 Engin Ozkaynak
- 👤 David C. Rueger
- 👤 Thangavel Kuberasampath
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:04
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61L; A61L27/00; A61L27/14; A61L27/22; A61L27/227; A61L27/36; A61L27/3604; A61L27/3608; A61L27/3641; A61L27/3645; A61L27/365; A61L27/50; A61L27/56; C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A61C; A61C8/00; A61C8/0003; A61C8/0004; A61C8/0006; A61K38/00; A61L2430/00; A61L2430/02
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
71 words
A DNA sequence which hybridizes with the DNA probe sequence: ##STR13## said DNA sequence encoding a polypeptide chain which, when expressed, associated with a second said polypeptide chain, oxidized to form a dimeric protein species and implanted together with a matrix in a mammal induces endochondral bone formation in said mammal, said dimeric protein species having a half maximum bone forming activity of at lest 25-50 ng per 25 mg matrix.
Claim 2
Dependent Claim
71 words
A DNA sequence which hybridizes with the DNA probe sequence: ##STR13## said DNA sequence encoding a polypeptide chain which, when expressed, associated with a second said polypeptide chain, oxidized to form a dimeric protein species and implanted together with a matrix in a mammal induces endochondral bone formation in said mammal, said dimeric protein species having a half maximum bone forming activity of at lest 25-50 ng per 25 mg matrix.
Claim 3
Dependent Claim
53 words
A DNA sequence useful as a probe for genetic sequences encoding an osteogenic polypeptide chain, said polypeptide chain being capable of inducing endochondral bone formation in a mammal when associated with a second polypeptide chain, oxidized to form a dimeric protein species, and implanted in said mammal in association with a matrix, ##STR14##
Claim 4
Dependent Claim
53 words
A DNA sequence useful as a probe for genetic sequences encoding an osteogenic polypeptide chain, said polypeptide chain being capable of inducing endochondral bone formation in a mammal when associated with a second polypeptide chain, oxidized to form a dimeric protein species, and implanted in said mammal in association with a matrix, ##STR14##
Claim 5
Dependent Claim
50 words
A DNA sequence comprising the sequence: ##STR15## said DNA sequence encoding a polypeptide chain which, when expressed, associated with a second polypeptide chain, oxidized to form a dimeric protein species and implanted in a mammal in association with a matrix, is capable of inducing endochondral bone formation in said mammal.
Claim 6
Dependent Claim
50 words
A DNA sequence comprising the sequence: ##STR15## said DNA sequence encoding a polypeptide chain which, when expressed, associated with a second polypeptide chain, oxidized to form a dimeric protein species and implanted in a mammal in association with a matrix, is capable of inducing endochondral bone formation in said mammal.
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