EP0148155A2
Expired / Lapsed
EP
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Osteogenic factors
Assignee: International Genetic Engineering Inc
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Filing: 1985-01-02
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Granted: —
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Expires: 2005-01-02
Abstract
Abstract A protein extracted from demineralized bone matrix exhibiting bone-inducing activity is disclosed as well as a method for the rapid isolation and purification of the protein to an essentially homogeneous state. Pharmaceutically acceptable compositions containing the bone-inducing protein and suitable pharmaceutical carriers are also described.
Inventors
- 👤 Arup Sen
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 03:21
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/475; C07K14/51; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
84 words
An essentially homogeneous osteogenic factor which is a member selected from the group consisting of: (a) a protein of the P3 family of immunologically related proteins characterized by having the capability, in its essentially homogeneous state, of promoting osteogenesis in a mammal; (b) an osteogenically active polypeptide derived from said protein; (c) a polypeptide which is or can be converted to an osteogenically active entity which is immunologically related to said protein; or (d) mixtures of osteogenic factors selected from (a), (b) and (c).
Claim 2
Dependent Claim
84 words
An essentially homogeneous osteogenic factor which is a member selected from the group consisting of: (a) a protein of the P3 family of immunologically related proteins characterized by having the capability, in its essentially homogeneous state, of promoting osteogenesis in a mammal; (b) an osteogenically active polypeptide derived from said protein; (c) a polypeptide which is or can be converted to an osteogenically active entity which is immunologically related to said protein; or (d) mixtures of osteogenic factors selected from (a), (b) and (c).
Claim 3
Dependent Claim
12 words
The P3 protein of Claim 1 which is isolated from bovine bone.
Claim 4
Dependent Claim
12 words
The P3 protein of Claim 1 which is isolated from human bone.
Claim 5
Dependent Claim
12 words
The P3 protein of Claim 1 which is isolated from porcine bone.
Claim 6
Dependent Claim
14 words
The protein of Claim 1 which has the amino terminal sequence H 2 N-Phe-Pro-val-Tyr-Asp-Tyr-ser-Pro-Ala--Arg-Leu-Lys-Glu-Ala.
Claim 7
Dependent Claim
42 words
A composition comprising (a) at least one osteogenic factor of Claim 1 and (b) at least one member selected from the group consisting essentially of (1) the P4 family of immunologically related proteins; and (2) the P2 family of immunologically related proteins.
Claim 8
Dependent Claim
31 words
A composition comprising (a) an osteogenic factor of Claim 1 derived from a particular mammalian species; and (b) one or more osteogenic factors of Claim 1 derived from different mammalian species.
Claim 9
Dependent Claim
27 words
A composition comprising (a) at least one of the osteogenic factors of Claim 1; and (b) at least one bioactive material other than those described in (a).
Claim 10
Dependent Claim
21 words
A composition comprised of a pharmaceutically acceptable carrier and an osteogenic amount of at least one osteogenic factor of Claim 1.
Claim 11
Dependent Claim
25 words
The composition of Claim 9 wherein the pharmaceutically acceptable carrier is collagen or a matrix material derived from powdered bone extracted with strong denaturing agents.
Claim 12
Dependent Claim
13 words
The composition of Claim 9 also containing at least one non-osteogenic bioactive ingredient.
References Cited (Backward Citations)
No citation records indexed.
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