US4776890A
Expired / Lapsed
US
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Preparation of collagen hydroxyapatite matrix for bone repair
Assignee: Angiotech Biomaterials Corp
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Filing: 1987-04-03
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Granted: 1988-10-11
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Expires: 2007-04-03
Abstract
Abstract An improved process for obtaining a matrix of mineral particles in reconstituted atelopeptide collagen comprises reconstituting a mixture of mineral particles with collagen in solution. This process results in a matrix of collagen containing the mineral particles which, when wetted, is malleable and retains its integrity.
Inventors
- 👤 George Chu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:16
CPC Classifications
A; A61; A61L; A61L27/00; A61L27/40; A61L27/44; A61L27/46
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
53 words
A method to prepare a mineral collagen matrix having mineral particles retained within a native collagen matrix, which method comprises dialyzing a mixture of mineral particles and non-fibrillar collagen in acidic solution against a reconstituting medium, said reconstituting medium comprising a precipitating, buffer solution selected so as to promote native collagen fiber formation.
Claim 2
Independent Claim
53 words
A method to prepare a mineral collagen matrix having mineral particles retained within a native collagen matrix, which method comprises dialyzing a mixture of mineral particles and non-fibrillar collagen in acidic solution against a reconstituting medium, said reconstituting medium comprising a precipitating, buffer solution selected so as to promote native collagen fiber formation.
Claim 3
Dependent Claim
15 words
The method of claim 1 wherein the mixture contains 1-10% collagen wt/wt of total solids.
Claim 4
Dependent Claim
18 words
The method of claim 1 wherein the reconstituting solution is phosphate buffer at physiological pH and ionic strength.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein the dialysis is conducted to maintain sterile conditions within the dialysis container.
Claim 6
Dependent Claim
12 words
The process of claim 4 which further includes drying the reconstituted matrix.
Claim 7
Dependent Claim
17 words
The process of claim 1 wherein the collagen in solution is at a concentration of 35-120 mg/ml.
Claim 8
Dependent Claim
12 words
The process of claim 1 wherein the mineral particles are hydroxylapatite particles.
Claim 9
Dependent Claim
13 words
The process of claim 7 wherein the hydroxylapatite is 20/40 or 40/60 mesh.
Claim 10
Dependent Claim
9 words
The matrix prepared by the method of claim 1.
Claim 11
Dependent Claim
17 words
A method for repairing bone defects which comprises administering to said defect the composition of claim 9.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-11 | 1992-04-11 | 1992-10-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-11 | 1996-04-11 | 1996-10-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-11 | 2000-04-11 | 2000-10-11 | $7700.00 | Window Closed / Lapsed |