Patent US5418136A successfully refreshed from Google Patents.
US5418136A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Devices for detection of an analyte based upon light interference
Assignee: Inverness Medical Biostar Inc
•
Filing: 1993-06-10
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Granted: 1995-05-23
•
Expires: 2013-06-10
Abstract
Abstract Optical assay device having an active receptive surface supported on a pedestal and held within a first container; the first container comprising first absorbent material located at the base of the pedestal, configured and arranged to absorb liquid draining from the surface, and having a second container, hingedly connected to one side of the first container, the second container comprising a second absorbent material, wherein the second container can be closed to the first container by rotation about the hinge, and wherein such closing causes the second absorbent material to contact the surface.
Inventors
- 👤 B. John Miller
- 👤 Diana M. Maul
- 👤 James Blessing
- 👤 Mark Crosby
- 👤 Howard Kelley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:31
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54366; G01N33/54373; Y; Y10; Y10S; Y10S435/00; Y10S435/808; Y10S435/974; Y10S436/00; Y10S436/805
Claims Analysis
Total Claims: 51
Claim 1
Independent Claim
148 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a dendrimer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 2
Dependent Claim
148 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a dendrimer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 3
Dependent Claim
149 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a star polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 4
Dependent Claim
149 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a star polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 5
Dependent Claim
149 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a molecular self-assembling polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material,.wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 6
Dependent Claim
149 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a molecular self-assembling polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material,.wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 7
Dependent Claim
149 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film; an attachment layer on Cop of said interference film, wherein said attachment layer comprises a polymeric siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material adjacent said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 8
Dependent Claim
149 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film; an attachment layer on Cop of said interference film, wherein said attachment layer comprises a polymeric siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material adjacent said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 9
Dependent Claim
148 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb livid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 10
Dependent Claim
148 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb livid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 11
Dependent Claim
150 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a film forming latex, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 12
Dependent Claim
150 words
An optical assay device comprising an optically active receptive surface comprising a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a film forming latex, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, wherein said surface is supported on a pedestal that is held within a first container; wherein said first container comprises a first absorbent material bordering said pedestal where said pedestal contacts said first container, wherein said first absorbent material is configured and arranged to absorb liquid draining from said surface, and a second container, hingedly connected to one side of said first container, said second container comprising a second absorbent material, wherein said second container can be closed to said first container by rotation about the hinge, and wherein such closing causes said second absorbent material to contact said surface.
Claim 13
Dependent Claim
27 words
The device of claim 1, 2, 3, 4, 5, or 6, wherein the analyte of interest is a host produced antibody to Human Immunodeficiency Virus (HIV) infection.
Claim 14
Dependent Claim
47 words
The device of claim 1, 2, 3, 4, 5, or 6, wherein the analyte of interest is a host produced antibody to a hepatitis infection, for Hepatitis A Virus (HAV), Hepatitis B Virus (HBV), Hepatitits C Virus (HCV), Hepatitis D Virus (HDV), or Hepatitis E Virus (HEV).
Claim 15
Dependent Claim
44 words
The device of claim 1, 2, 3, 4, 5, or 6, wherein the analyte of interest is one or more antigens from Hepatitis, Hepatitis A Virus (HAV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Hepatitis D Virus (HDV), or Hepatitis E. Virus (HEV).
Claim 16
Dependent Claim
19 words
The device of claim 1, 2, 3, 4, 5, or 6, wherein the analyte of interest is Lipopolysaccharide (LPS).
Claim 17
Dependent Claim
47 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein said second container further comprises a handle configured and arranged to cause said second absorbent material to move laterally relative to a location at which said second absorbent material contacts said optically active receptive surface.
Claim 18
Dependent Claim
32 words
The device of claim 11 wherein said device further comprises a movable flap in said second container which is configured and arranged to retain said second absorbent material within said second container.
Claim 19
Dependent Claim
15 words
The device of claim 12 wherein said flap is hingedly connected to said second container.
Claim 20
Dependent Claim
23 words
The device of claim 12 wherein said flap is provided with one or more apertures to allow access to said second absorbent material.
Claim 21
Dependent Claim
32 words
The device of claim 11 wherein said device further comprises a moveable flap in said first container which is configured and arranged to retain said first absorbent material within said first container.
Claim 22
Dependent Claim
15 words
The device of claim 15, wherein said flap is hingedly connected to said first container.
Claim 23
Dependent Claim
38 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein said device further comprises a movable flap in said second container which is configured and arranged to retain said second absorbent material within said second container.
Claim 24
Dependent Claim
18 words
The device of claim 17 wherein each said flap is hingedly connected to said first or second container.
Claim 25
Dependent Claim
23 words
The device of claim 17 wherein said flap is provided with one or more apertures to allow access to said second absorbent material.
Claim 26
Dependent Claim
38 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein said device further comprises a moveable flap in said first container which is configured and arranged to retain said first absorbent material within said first container.
Claim 27
Dependent Claim
27 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is the Immunodeficiency Virus (HIV) I or II or a combination.
Claim 28
Dependent Claim
20 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is Streptococcus Group A.
Claim 29
Dependent Claim
20 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is Streptococcus Group B.
Claim 30
Dependent Claim
20 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is Respiratory Syncytial virus.
Claim 31
Dependent Claim
19 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is Hepatitis B.
Claim 32
Dependent Claim
19 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is Chlamydia species.
Claim 33
Dependent Claim
20 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is Herpes Simplex virus.
Claim 34
Dependent Claim
36 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein the analyte of interest is an antigen, an antibody, nucleic acid, oligonucleotides, chelators, enzymes, bacteria, viruses, hormones or receptors for said analytes of interest.
Claim 35
Dependent Claim
38 words
The device of claim 1, 2, 3, 4, 5, or 6 wherein said device is configured and arranged to measure the presence of amount of Streptococcus A antigen, Streptococcus B, Respiratory Syncytial Virus, Chlamydia or a Hepatitis antigen.
Claim 36
Dependent Claim
101 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a dendrimer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 37
Dependent Claim
101 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a dendrimer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 38
Dependent Claim
102 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a star polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 39
Dependent Claim
102 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a star polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 40
Dependent Claim
103 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a molecular self-assembling polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 41
Dependent Claim
103 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a molecular self-assembling polymer, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 42
Dependent Claim
102 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a polymeric siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 43
Dependent Claim
102 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a polymeric siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 44
Dependent Claim
101 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 45
Dependent Claim
101 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a siloxane, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device.
Claim 46
Dependent Claim
103 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a film forming latex, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device,
Claim 47
Dependent Claim
103 words
An optical assay device, comprising a plurality of optically active receptive surfaces, wherein each optically active receptive surface comprises a thin interference film, an attachment layer on top of said interference film, wherein said attachment layer comprises a film forming latex, and a layer containing specific binding reagents to an analyte of interest attached to said attachment layer, supported on a base, said base comprising a first absorbent material configured and arranged to absorb liquid draining from said surfaces, and a slidable lid comprising one or more absorbent regions configured and arranged to contact said optically active surfaces during use of the device,
Claim 48
Dependent Claim
33 words
The device of claim 30, 31, 32, 33, 34, or 35 wherein said device is provided with step means on said base to allow stepped movement of said lid relative to said base.
Claim 49
Dependent Claim
31 words
The device of claim 30, 31, 32, 33, 34, or 35 wherein said lid comprises a series of apertures which allow selected access to said surfaces during use of said device.
Claim 50
Dependent Claim
43 words
The device of claim 30, 31, 32, 33, 34, or 35 wherein said lid comprises an elongated aperture and wherein said base comprises a series of indicia, wherein said elongated aperture cooperates with said indicia to indicate method for use of the device.
Claim 51
Dependent Claim
38 words
The device of claim 30, 31, 32, 33, 34, or 35, wherein said device is configured and arranged to measure the presence of amount of Streptococcus A antigen, Streptococcus B, Respiratory Syncytial virus, Chlamydia or a Hepatitis antigen.
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| 7.5 Years (Year 8) | 2002-05-22 | 2002-11-21 | 2003-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2006-05-22 | 2006-11-21 | 2007-05-23 | $7700.00 | Window Closed / Lapsed |