US4357142A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Glass support coated with synthetic polymer for bioprocess
Assignee: Akzona Inc
•
Filing: 1980-07-18
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Granted: 1982-11-02
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Expires: 2000-07-18
Abstract
Abstract A new and useful process is disclosed for manufacturing a device for use in a bioprocess, comprising: (a) providing solid support means insoluble in water or organic solvent solutions; (b) coating said solid support means with organic-solvent based polymeric film means capable of applying one or more biomaterials; and (c) adsorbing or covalently bonding at least one functional biomaterial to said polymeric film means. The polymeric film means, for example, can be used to coat antigens, antibodies, haptens, enzymes, living bacteria, yeasts, etc. (i.e., biomaterials) to a glass (or other) support material, e.g., a glass tube, with surprising retention of the biomaterial's essential characteristic properties. The solid support means include but are not limited to those comprising glass, ceramics, metals, polymers and woods. The device of the invention is particularly useful in various immunoassays using a solid support for separation of phases.
Inventors
- 👤 Roy F. Schall, Jr.
- 👤 Stephen J. Lewis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 06:15
CPC Classifications
C; C12; C12N; C12N11/00; C12N11/14; A; A61; A61K; A61K39/00; A61K39/395; A61K39/44; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/551; G01N33/552; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/815; Y10S530/817
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
57 words
Device for use in a bioprocess, comprising: (a) transparent glass solid support means insoluble in a solvent solution, selected from the group consisting of water and organic solvent solutions which solid support means is coated with organic-solvent based synthetic polymeric film means and (b) one or more functional biomaterials adsorbed or covalently bonded to said polymeric films.
Claim 2
Dependent Claim
57 words
Device for use in a bioprocess, comprising: (a) transparent glass solid support means insoluble in a solvent solution, selected from the group consisting of water and organic solvent solutions which solid support means is coated with organic-solvent based synthetic polymeric film means and (b) one or more functional biomaterials adsorbed or covalently bonded to said polymeric films.
Claim 3
Dependent Claim
13 words
Device of claim 1, wherein the solid support means is water-insoluble and water-insuspensible.
Claim 4
Dependent Claim
31 words
Device of claim 1 or claim 2, wherein the functional biomaterial is selected from the group consisting of an antigen, an antibody and a hapten, and the bioprocess is an immunoassay.
Claim 5
Dependent Claim
55 words
Process for manufacturing of a device for use in a bioprocess, comprising: (a) providing a transparent glass solid support means insoluble in water or organic solvent solutions; (b) coating said solid support means with organic-solvent-based synthetic polymeric film means; and (c) absorbing or covalently bonding at least one functional biomaterial to said polymeric film means.
Claim 6
Dependent Claim
55 words
Process for manufacturing of a device for use in a bioprocess, comprising: (a) providing a transparent glass solid support means insoluble in water or organic solvent solutions; (b) coating said solid support means with organic-solvent-based synthetic polymeric film means; and (c) absorbing or covalently bonding at least one functional biomaterial to said polymeric film means.
Claim 7
Dependent Claim
14 words
The process of claim 4, wherein the solid support means is water-insoluble and water-insuspensible.
Claim 8
Dependent Claim
32 words
The process of claim 4 or claim 5, wherein the functional biomaterial is selected from the group consisting of an antigen, an antibody and a hapten, and the bioprocess is an immunoassay.
Claim 9
Dependent Claim
65 words
Bioprocess using a device containing at least one functional biomaterial, the improvement wherein the device comprises: (a) transparent glass solid support means insoluble in a solvent selected from the group consisting of water and organic solvent solutions, which solid support means is coated with organic-solvent based synthetic polymeric film means; and (b) one or more functional biomaterials adsorbed or covalently bonded to said polymeric films.
Claim 10
Dependent Claim
65 words
Bioprocess using a device containing at least one functional biomaterial, the improvement wherein the device comprises: (a) transparent glass solid support means insoluble in a solvent selected from the group consisting of water and organic solvent solutions, which solid support means is coated with organic-solvent based synthetic polymeric film means; and (b) one or more functional biomaterials adsorbed or covalently bonded to said polymeric films.
Claim 11
Dependent Claim
14 words
The bioprocess of claim 7, wherein the solid support means is water-insoluble and water-insuspensible.
Claim 12
Dependent Claim
32 words
The bioprocess of claim 7 or claim 8, wherein the functional biomaterial is selected from the group consisting of an antigen, an antibody and a hapten, and the bioprocess is an immunoassay.
Claim 13
Dependent Claim
142 words
Process for manufacture of a device for use in a bioprocess, comprising: (a) providing transparent glass solid support means insoluble in water or organic solvent solutions; (b) heating an organic-solvent-based, film-forming synthetic polymeric suspension from about 20° C. to about 100° C.; (c) coating said solid support means with said heated aqueous-solvent polymeric suspension; (d) drying the coated solid support means to remove any organic solvent to form a polymeric film on said solid support means; (e) heating the solid support means having said film from about 20° C. to about 200° C. for a time sufficient to cure said film; (f) cooling the solid support means having said cured film to a temperature suitable for applying one or more functional biomaterials to said cured film; and (g) adsorbing or covalently bonding at least one functional biomaterial to said polymeric film means.
Claim 14
Dependent Claim
142 words
Process for manufacture of a device for use in a bioprocess, comprising: (a) providing transparent glass solid support means insoluble in water or organic solvent solutions; (b) heating an organic-solvent-based, film-forming synthetic polymeric suspension from about 20° C. to about 100° C.; (c) coating said solid support means with said heated aqueous-solvent polymeric suspension; (d) drying the coated solid support means to remove any organic solvent to form a polymeric film on said solid support means; (e) heating the solid support means having said film from about 20° C. to about 200° C. for a time sufficient to cure said film; (f) cooling the solid support means having said cured film to a temperature suitable for applying one or more functional biomaterials to said cured film; and (g) adsorbing or covalently bonding at least one functional biomaterial to said polymeric film means.
Claim 15
Dependent Claim
23 words
The process of claim 10, wherein the solid support means is heated in step (e) from about 1 minute to about 2 hours.
Claim 16
Dependent Claim
19 words
The process of claim 10, wherein the solid support means is cooled in step (f) to about room temperature.
Claim 17
Dependent Claim
13 words
The process of claim 10, wherein the solid support is water-insoluble and water-insuspensible.
Claim 18
Dependent Claim
29 words
The process of claim 10, wherein the functional biomaterial is selected from the group consisting of an antibody, an antibody and a hapten, and the bioprocess is an immunoassay.
Claim 19
Dependent Claim
16 words
The process of claim 10, wherein the solid support means consists essentially of a glass tube.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-01 | 1986-05-03 | 1986-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-01 | 1990-05-03 | 1990-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-01 | 1994-05-03 | 1994-11-02 | $7700.00 | Window Closed / Lapsed |