US5290271A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Surgical implant and method for controlled release of chemotherapeutic agents
Assignee: DERMAGENESIS LLC
•
Filing: 1993-07-29
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Granted: 1994-03-01
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Expires: 2013-07-29
Abstract
Abstract An implant and method is disclosed using microparticles to provide a controlled, sustained release, and improved cellular uptake, of chemotherapeutic agents.
Inventors
- 👤 Gary R. Jernberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 12:50
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/08; A61L; A61L27/00; A61L27/50; A61L27/54; A61F2210/00; A61F2210/0004; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406; A61L2300/41; A61L2300/42; A61L2300/60; A61L2300/602; A61L2300/62; A61L2300/622
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
113 words
A surgical implant comprising a porous matrix, said matrix further containing time-release microshapes encapsulating at least one chemotherapeutic agent incorporated into said porous matrix, wherein said time-release microshapes will begin to release said at least one chemotherapeutic agent at a localized treatment site upon surgical implantation of said implant, said implant further containing means for improving the cellular uptake of said at least one chemotherapeutic agent at the localized treatment site upon surgical implantation of said implant, said means comprising at least one carrier agent incorporated into the matrix of said implant, said implant selected from the group consisting of a vascular graft, heart valve leaflet, ligament prosthesis, tendon prosthesis and urethral prosthesis.
Claim 2
Dependent Claim
113 words
A surgical implant comprising a porous matrix, said matrix further containing time-release microshapes encapsulating at least one chemotherapeutic agent incorporated into said porous matrix, wherein said time-release microshapes will begin to release said at least one chemotherapeutic agent at a localized treatment site upon surgical implantation of said implant, said implant further containing means for improving the cellular uptake of said at least one chemotherapeutic agent at the localized treatment site upon surgical implantation of said implant, said means comprising at least one carrier agent incorporated into the matrix of said implant, said implant selected from the group consisting of a vascular graft, heart valve leaflet, ligament prosthesis, tendon prosthesis and urethral prosthesis.
Claim 3
Dependent Claim
17 words
The surgical implant of claim 1 wherein the carrier agent is hyaluronic acid or a derivative thereof.
Claim 4
Dependent Claim
16 words
The surgical implant of claim 1 wherein the carrier agent is encapsulated in a time-release microshape.
Claim 5
Dependent Claim
37 words
The surgical implant of claim 1 wherein the carrier agent is mixed with the at least one chemotherapeutic agent and encapsulated in said time-release microshape prior to incorporating said time-release microshapes into said matrix of said implant.
Claim 6
Dependent Claim
12 words
The implant of claim 1 being constructed of a biodegradable, resorbable material.
Claim 7
Dependent Claim
19 words
The implant of claim 5, wherein said biodegradable, resorbable material is cross-linked collagen or an ester of hyaluronic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1997-02-28 | 1997-08-30 | 1998-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 2001-02-28 | 2001-08-30 | 2002-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2005-02-28 | 2005-08-30 | 2006-03-01 | $7700.00 | Window Closed / Lapsed |