US4536387A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-cancer device
Assignee: Unitika Ltd
•
Filing: 1983-02-14
•
Granted: 1985-08-20
•
Expires: 2003-02-14
Abstract
Abstract An anti-cancer device having an anti-cancer drug and a blood coagulation factor fixed to a structure. This anti-cancer device is used in transcatheter arterial embolization and needle therapy with advantage and slowly releases the anti-cancer drug over an extended period by staying in the cancer tissue and its nearby area.
Inventors
- 👤 Izumi Sakamoto
- 👤 Kunihiko Takagi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:03
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/51; A61K47/62; A61K47/56; A61K47/59; A61K47/595; A61K47/61
Claims Analysis
Total Claims: 55
Claim 1
Independent Claim
73 words
A method of transcatheter arterial embolization and needle therapy comprising injecting a patient with composition useful for transcatheter arterial embolization and needle therapy comprising: (a) a polymer, wherein said polymer has fixed thereto; (b) an anti-cancer drug; and (c) a blood coagulation factor, wherein said anti-cancer drug and said blood coagulation factor are fixed to said polymer so as to be capable of sustained release from the polymer at the site of injection.
Claim 2
Independent Claim
73 words
A method of transcatheter arterial embolization and needle therapy comprising injecting a patient with composition useful for transcatheter arterial embolization and needle therapy comprising: (a) a polymer, wherein said polymer has fixed thereto; (b) an anti-cancer drug; and (c) a blood coagulation factor, wherein said anti-cancer drug and said blood coagulation factor are fixed to said polymer so as to be capable of sustained release from the polymer at the site of injection.
Claim 3
Dependent Claim
14 words
The method as claimed in claim 1, wherein said polymer is a synthetic polymer.
Claim 4
Dependent Claim
13 words
The method as claimed in claim 2, wherein said synthetic polymer is silicone.
Claim 5
Dependent Claim
25 words
The method as claimed in claim 1, wherein said polymer is selected from the group consisting of cellulosic material, cellulosic material derivative and regenerated cellulose.
Claim 6
Dependent Claim
15 words
The method as claimed in claim 4, wherein said cellulosic material derivative is ethyl cellulose.
Claim 7
Dependent Claim
13 words
The method as claimed in claim 1, wherein said polymer is bioabsorbable material.
Claim 8
Dependent Claim
13 words
The method as claimed in claim 6, wherein said bioabsorbable material is polysaccharide.
Claim 9
Dependent Claim
12 words
The method as claimed in claim 7, wherein said polysaccharide is amylose.
Claim 10
Dependent Claim
13 words
The method as claimed in claim 7, wherein said polysaccharide is oxidized cellulose.
Claim 11
Dependent Claim
12 words
The method as claimed in claim 7, wherein said polysaccharide is chitin.
Claim 12
Dependent Claim
13 words
The method as claimed in claim 6, wherein said bioabsorbable material is collagen.
Claim 13
Dependent Claim
13 words
The method as claimed in claim 6, wherein said bioabsorbable material is gelatin.
Claim 14
Dependent Claim
14 words
The method as claimed in claim 6, wherein said bioabsorbable material is polyamino acid.
Claim 15
Dependent Claim
14 words
The method as claimed in claim 13, wherein said polyamino acid is polyglycolic acid.
Claim 16
Dependent Claim
14 words
The method as claimed in claim 13, wherein said polyamino acid is polylactic acid.
Claim 17
Dependent Claim
18 words
The method as claimed in claim 1, wherein the polymer is in the form of a fibrous assembly.
Claim 18
Dependent Claim
18 words
The method as claimed in claim 16, wherein said fibrous assembly is an assembly of oxidized cellulose fiber.
Claim 19
Dependent Claim
17 words
The method as claimed in claim 16, wherein said fibrous assembly is an assembly of gelatin fiber.
Claim 20
Dependent Claim
17 words
The method as claimed in claim 16, wherein said fibrous assembly is an assembly of chitin fiber.
Claim 21
Dependent Claim
17 words
The method as claimed in claim 1, wherein said polymer is in the form of a sponge.
Claim 22
Dependent Claim
14 words
The method as claimed in claim 20, wherein said sponge is oxidized cellulose sponge.
Claim 23
Dependent Claim
13 words
The method as claimed in claim 20, wherein said sponge is gelatin sponge.
Claim 24
Dependent Claim
13 words
The method as claimed in claim 20, wherein said sponge is chitin sponge.
Claim 25
Dependent Claim
17 words
The method as claimed in claim 1, wherein said polymer is in the form of a powder.
Claim 26
Dependent Claim
14 words
The method as claimed in claim 24, wherein said powder is oxidized cellulose powder.
Claim 27
Dependent Claim
13 words
The method as claimed in claim 24, wherein said powder is gelatin powder.
Claim 28
Dependent Claim
13 words
The method as claimed in claim 24, wherein said powder is chitin powder.
Claim 29
Dependent Claim
17 words
The method as claimed in claim 1, wherein said polymer is in the form of a monofilament.
Claim 30
Dependent Claim
17 words
The method as claimed in claim 1, wherein said polymer is in the form of a film.
Claim 31
Dependent Claim
17 words
The method as claimed in claim 1, wherein said polymer is in the form of a microcapsule.
Claim 32
Dependent Claim
15 words
The method as claimed in claim 1, wherein said anti-cancer drug is an alkylating agent.
Claim 33
Dependent Claim
19 words
The method as claimed in claim 1, wherein said anti-cancer drug is a combination of cyclophosphamide, 5-fluorouracil and mitomycin.
Claim 34
Dependent Claim
19 words
The method as claimed in claim 1, wherein said anti-cancer drug is a combination of cyclophosphamide, 5-fluorouracil and bleomycin.
Claim 35
Dependent Claim
13 words
The method as claimed in claim 1, wherein said anti-cancer drug is bleomycin.
Claim 36
Dependent Claim
14 words
The method as claimed in claim 1, wherein said anti-cancer drug is mitomycin C.
Claim 37
Dependent Claim
13 words
The method as claimed in claim 1, wherein said anti-cancer drug is adriamycin.
Claim 38
Dependent Claim
13 words
The method as claimed in claim 1, wherein said anti-cancer drug is 5-fluorouracil.
Claim 39
Dependent Claim
15 words
The method as claimed in claim 1, wherein said blood coagulation factor is Factor XIII.
Claim 40
Dependent Claim
14 words
The method as claimed in claim 1, wherein said blood coagulation factor is thrombin.
Claim 41
Dependent Claim
20 words
The method as claimed in claim 1, wherein said blood coagulation factor is a combination of Factor XIII and thrombin.
Claim 42
Dependent Claim
26 words
The method as claimed in claim 1, wherein said anti-cancer drug and blood coagulation factor are fixed to the polymer by covalently bonding to the polymer.
Claim 43
Independent Claim
35 words
The method as claimed in claims 1, 6, 16, 20, 24, 28, 29 or 30, wherein said anti-cancer drug and blood coagulation factor are fixed to the said polymer by ionically bonding to said polymer.
Claim 44
Independent Claim
30 words
The method as claimed in claims 1, 6, 16, 20, 24, 28, 29 or 30, wherein said anti-cancer drug and blood coagulation factor are fixed to said polymer by adsorption.
Claim 45
Independent Claim
30 words
The method as claimed in claims 1, 6, 16, 20, 24, 28, 29 or 30, wherein said anti-cancer drug and blood coagulation factor are fixed to said polymer for entrapping.
Claim 46
Dependent Claim
16 words
The method as claimed in claim 1, wherein calcium ion is additionally fixed to said polymer.
Claim 47
Dependent Claim
16 words
The method as claimed in claim 1, wherein a pharmaceutical is additionally fixed to said polymer.
Claim 48
Dependent Claim
27 words
The method as claimed in claim 46, wherein said pharmaceutical is selected from the group consisting of protease inhibitors, plasma proteins, fibronectin, antiboitics, antivirals, sulfaniamides and anti-infectives.
Claim 49
Dependent Claim
26 words
The method as claimed in claim 1, wherein said polymer is a bioabsorbable polymer and wherein said polymer is in the form of a fibrous assembly.
Claim 50
Dependent Claim
25 words
The method as claimed in claim 1, wherein said polymer is a bioabsorbable material and wherein said polymer is in the form of a sponge.
Claim 51
Dependent Claim
25 words
The method as claimed in claim 1, wherein said polymer is a bioabsorbable material and wherein said polymer is in the form of a powder.
Claim 52
Dependent Claim
25 words
The method as claimed in claim 1, wherein said polymer is a bioabsorbable material and wherein said polymer is in the form of a monofilament.
Claim 53
Dependent Claim
25 words
The method as claimed in claim 1, wherein said polymer is a bioabsorbable material and wherein said polymer is in the form of a film.
Claim 54
Dependent Claim
25 words
The method as claimed in claim 1, wherein said polymer is a bioabsorbable material and wherein said polymer is in the form of a microcapsule.
Claim 55
Dependent Claim
52 words
The method as claimed in claim 1, wherein said polymer is gelatin powder, said anti-cancer drug, and said blood coagulation factor are fixed to said polymer by ionic bonding, entrapping and adsorption, said anti-cancer drug is mitomycin C and wherein said blood coagulation factor is a combination of Factor XIII and thrombin.
References Cited (Backward Citations)
GB584497A
Cited
US2487975A
Cited
GB642380A
Cited
US2961374A
Cited
US3089815A
Cited
US2669537A
Cited
US3009856A
Cited
US3749774A
Cited
US3932624A
Cited
JPS5334915A
Cited
US4321117A
Cited
US4411754A
Cited
US4444753A
Cited
US4359483A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-19 | 1989-02-18 | 1989-08-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-19 | 1993-02-18 | 1993-08-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-19 | 1997-02-18 | 1997-08-20 | $7700.00 | Window Closed / Lapsed |