US4444753A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical composition comprising extract from poison pouch contents of bee
Assignee: Toyama Chemical Co Ltd
•
Filing: 1982-09-30
•
Granted: 1984-04-24
•
Expires: 2002-09-30
Abstract
Abstract A composition comprising a component obtained by deproteinizing an extract from the poison pouch contents of bee has an immunostimulating activity, a carcinostatic activity, an effect of enhancing the antibacterial activity of an antibacterial substance and an effect of enhancing the carcinostatic activity of a carcinostatic substance. This invention is directed to a carcinostatic, immunostimulating and antibacterial agent comprising said composition.
Inventors
- 👤 Isamu Saikawa
- 👤 Takashi Yasuda
- 👤 Shohachi Murakami
- 👤 Toyoo Maeda
- 👤 Akira Yotsuji
- 👤 Masahiro Takahata
- 👤 Hisatsugu Tsuda
- 👤 Hidetada Mikami
- 👤 Hiroshi Sakai
- 👤 Toshinori Ohashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:19
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/56; A61K35/63; A61P; A61P31/00; A61P31/04; A61P35/00; A61P37/00; A61P37/02; A61P37/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
26 words
An antibacterial agent comprising an effective amount of a component obtained by deproteinizing an extract from the poison pouch contents of bee and an antibacterial substance.
Claim 2
Dependent Claim
26 words
An antibacterial agent comprising an effective amount of a component obtained by deproteinizing an extract from the poison pouch contents of bee and an antibacterial substance.
Claim 3
Dependent Claim
31 words
An antibacterial agent according to claim 1, wherein the component obtained by deproteinizing an extract from the poison pouch contents of bee is negative in biuret reaction and sulfosalicylic acid reaction.
Claim 4
Dependent Claim
93 words
An antibacterial agent according to claim 1 or 2, wherein the component obtained by deproteinizing an extract from the poison pouch contents of bee is obtained by extracting the poison pouch contents of bee with water or an aqueous sodium chloride solution, heating the extract to 50° to 100° C., removing the resulting precipitates, adjusting the pH of the mother liquor to 3.8 to 5.0, removing the resulting precipitates, heating the filtrate to 50° to 100° C., removing the resulting precipitates, adding an ether to the filtrate, and then removing the ether-soluble fraction.
Claim 5
Dependent Claim
67 words
An antibacterial agent according to claim 1 or 2, wherein the component obtained by deproteinizing an extract from the poison pouch contents of bee is obtained by extracting the poison pouch contents of bee with acidic distilled water containing sodium chloride, heating the extract obtained to 50° to 100° C., removing the resulting precipitates, adding carbolic acid to the supernatent solution, and then filtering the resulting mixture.
Claim 6
Dependent Claim
110 words
An antibacterial agent according to claim 1 or 2, wherein the component obtained by deproteinizing an extract from the poison pouch contents of bee is obtained by extracting the poison pouch contents of bee with water or an aqueous sodium chloride solution, heating the extract to 50° to 100° C., removing the resulting precipitates, adding to the mother liquor water or an aqueous sodium chloride solution containing carbolic acid, removing the resulting precipitates, adjusting the pH of the mother liquor to 5 to 7, heating the mother liquor to 50° to 100° C., freezing it at -5° to -30° C., thereafter melting it gradually, and then removing the resulting precipitates.
Claim 7
Dependent Claim
11 words
An antibacterial agent according to claim 3, which has been freeze-dried.
Claim 8
Dependent Claim
23 words
An antibacterial agent according to claim 1, wherein the antibacterial substance is selected from the group consisting of β-lactam-type antibiotics and aminoglycoside-type antibiotics.
Claim 9
Dependent Claim
23 words
An antibacterial agent according to claim 7, wherein the β-lactam-type antibiotics are selected from the group consisting of penicillin-type antibiotics and cephalosporin-type antibiotics.
Claim 10
Dependent Claim
11 words
An antibacterial agent according to claim 4, which has been freeze-dried.
Claim 11
Dependent Claim
11 words
An antibacterial agent according to claim 5, which has been freeze-dried.
References Cited (Backward Citations)
JPS5457991A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-24 | 1987-10-24 | 1988-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-24 | 1991-10-24 | 1992-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-24 | 1995-10-24 | 1996-04-24 | $7700.00 | Window Closed / Lapsed |