US4685883A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Local delivery of chemotherapeutic agents for the treatment of periodontal disease
Assignee: Individual
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Filing: 1985-07-26
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Granted: 1987-08-11
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Expires: 2005-07-26
Abstract
Abstract A method for local delivery of chemotherapeutic agent (12) to a localized site in the mouth is disclosed. The method of delivery includes displacement or reflection of gingival tissues (20) from the tooth, in the area to be treated, to facilitate access to the periodontal lesion (16). A biodegradable, time-release microsphere (10) capsulating the chemotherapeutic agent is next positioned in the lesion (16). Accordingly, localized delivery of chemotherapeutic agent (12) continuously over a predetermined period of time is provided.
Inventors
- 👤 Gary R. Jernberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:31
CPC Classifications
A; A61; A61M; A61M31/00; A61M31/002; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0063; A61J; A61J7/00; A61J7/0092
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
121 words
A method for local delivery of chemotherapeutic agents to localized sites in the mouth for treatment of periodontal disease, comprising the steps of: (a) displacing gingival tissue away from the surface of the root portion of a tooth so as to form a vacuous cavity between the tooth and the tissue within a peridontal pocket; (b) insertion of biodegradable, time-release microshapes encapsulating chemotherapeutic agents, into the vacuous cavity between the tooth and the tissue within the periodontal pocket; and (c) allowing the displaced gingival tissue to return substantially to its orginial position for retention of the biodegradable, time-release microspheres in the periodontal pocket whereby the biodegradable, time-release microspheres will begin to degrade and release the chemotherapeutic agents at a localized site.
Claim 2
Independent Claim
121 words
A method for local delivery of chemotherapeutic agents to localized sites in the mouth for treatment of periodontal disease, comprising the steps of: (a) displacing gingival tissue away from the surface of the root portion of a tooth so as to form a vacuous cavity between the tooth and the tissue within a peridontal pocket; (b) insertion of biodegradable, time-release microshapes encapsulating chemotherapeutic agents, into the vacuous cavity between the tooth and the tissue within the periodontal pocket; and (c) allowing the displaced gingival tissue to return substantially to its orginial position for retention of the biodegradable, time-release microspheres in the periodontal pocket whereby the biodegradable, time-release microspheres will begin to degrade and release the chemotherapeutic agents at a localized site.
Claim 3
Dependent Claim
24 words
A method in accordance with claim 1, wherein insertion of the biodegradable miscroshapes is accomplished using a syringe apparatus and viscous liquid carrying medium.
Claim 4
Dependent Claim
31 words
A method in accordance with claim 1, wherein said biodegradable, time-release microshapes have different time release values thereby assuring generally continuous release of chemotherapeutic agents over an extended period of time.
Claim 5
Dependent Claim
24 words
A method in accordance with claim 1, wherein said insertion step includes inserting into the periodontal pocket time release microspheres having different release rates.
Claim 6
Independent Claim
120 words
a method for local delivery of chemotherapeutic agents to localized sites in the mouth for the treatment of periodontal disease, comprising the steps of: (a) displacing gingival tissue away from the surface of the root portion of a tooth so as to form a vacuous cavity between the tooth and the tissue within a periodontal pocket (b) adhesively positioning a biodegradable matrix including a chemotherpeutic agent thereon, subgingivally on the surface of the root portion of the tooth proximate the vacuous cavity formed between the tooth and the tissue within the periodontal pocket and (c) returning the displaced gingival tissue to substantially its original position, the gingival tissue thereby assisting in retention of the chemotherapeutic agent in the periodontal pocket.
Claim 7
Independent Claim
120 words
a method for local delivery of chemotherapeutic agents to localized sites in the mouth for the treatment of periodontal disease, comprising the steps of: (a) displacing gingival tissue away from the surface of the root portion of a tooth so as to form a vacuous cavity between the tooth and the tissue within a periodontal pocket (b) adhesively positioning a biodegradable matrix including a chemotherpeutic agent thereon, subgingivally on the surface of the root portion of the tooth proximate the vacuous cavity formed between the tooth and the tissue within the periodontal pocket and (c) returning the displaced gingival tissue to substantially its original position, the gingival tissue thereby assisting in retention of the chemotherapeutic agent in the periodontal pocket.
Claim 8
Dependent Claim
18 words
A method in accordance with claim 5, wherein said matrix is removed after a predetermined period of time.
Claim 9
Dependent Claim
27 words
A method in accordance with claim 6, wherein adhesive means utilized for adhesively positioning the biodegradable matrix on the root portion of the tooth is also biodegradable.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-08-10 | 1991-02-09 | 1991-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-08-10 | 1995-02-09 | 1995-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-08-10 | 1999-02-09 | 1999-08-11 | $7700.00 | Window Closed / Lapsed |